Smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women

Franklin, Teresa R.; Jagannathan, Kanchana; Spilka, Nathaniel; Keyser, Heather; Rao, H. Raghav; Ely, Alice V.; Janes, Amy C.; Wetherill, Reagan R.

doi:10.1016/j.drugalcdep.2021.108593

Cited by 5 publications

(2 citation statements)

References 71 publications

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“…Our findings are consistent with the neuroimaging literature in other substance use disorders (e.g. nicotine, stimulant use disorder) that propose that higher RSFC between DLPFC and brain regions known to process reward can protect from relapse risk [10][11][12][13].…”

Section: Introductionsupporting

confidence: 91%

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Camchong

Fiecas

Gilmore

et al. 2022

Preprint

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BackgroundBrain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Neuroimaging evidence suggests higher fronto-striatal connectivity as well as higher within-network connectivity of theoretically defined addiction networks is associated with reduced relapse rates and extended abstinence during follow-up periods.Objective/HypothesisA longitudinal randomized double-blind sham-controlled clinical trial investigated whether a non-invasive neuromodulation intervention delivered during early abstinence can (i) modulate connectivity of addiction networks supporting abstinence and (ii) improve relapse rates. Hypotheses: Active transcranial direct current stimulation (tDCS) will (i) increase connectivity of addiction networks known to support abstinence and (ii) reduce relapse rates.MethodsShort-term abstinent AUD participants (n=60) were assigned to 5 days of either active tDCS or sham during cognitive training. Causal discovery analysis (CDA) examined the directional influence from left dorsolateral prefrontal cortex (LDLPFC, stimulation site) to addiction networks that support abstinence.ResultsActive tDCS had an effect on the average strength of CDA-determined connectivity from LDLPFC to the incentive salience and negative emotionality addiction networks - increasing in the active tDCS group and decreasing in the sham group. Active tDCS had an effect on relapse rates 1-month following the intervention, with lower probability of relapse in the active tDCS vs. sham groups. Active tDCS showed an unexpected sex-dependent effect on relapse rates.ConclusionOur results suggest that LDLPFC stimulation delivered during early abstinence has an effect on addiction networks supporting abstinence and on relapse rates. The unexpected sex-dependent neuromodulation effects need to be further examined in larger clinical trials.

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Section: Introductionsupporting

confidence: 91%

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Camchong

Fiecas

Gilmore

et al. 2022

Preprint

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“…In a clinical context, studies suggest that iTBS exerts top-down regulatory effects on the DLPFC-striatal circuit. A study has shown that smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women (Franklin, Jagannathan et al 2021) and the relationship between the fiber connectivity integrity of the L-DLPFC-caudate and smoking cue-induced caudate activation can be mediated by the functional coupling strength of this circuit in smokers (Yuan, Yu et al 2017). More importantly, subthreshold iTBS over L-DLPFC shows the beneficial effects in attenuating craving for cocaine, reducing intake, and prolonging abstinence in treatment-seekers (Sanna, Fattore et al 2019), and FC of the L-DLPFC to striatum predicts treatment response of depression to TMS (Avissar, Powell et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Intermittent theta burst stimulation (iTBS)-induced changes of resting-state brain entropy (BEN)

Liu,

Song,

Deng

et al. 2024

Preprint

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Intermittent theta burst stimulation (iTBS) is a novel protocol of repetitive transcranial magnetic stimulation (rTMS). While iTBS has shown better therapeutic effects for depression than conventional high-frequency rTMS (HF-rTMS), its underlying neuronal mechanism remains elusive. Brain entropy (BEN), a measure of irregularity of brain activity, has recently emerged as a novel marker of regional brain activity. Our previous studies have shown the sensitivity of BEN to depression and HF-rTMS, suggesting BEN as a sensitive tool for understanding the brain mechanism of iTBS. To assess this possibility, we calculated BEN using resting state fMRI data provided by an open dataset in OpenNeuro. Sixteen healthy participants underwent 600 pulses of iTBS applied over the left dorsolateral prefrontal cortex (L-DLPFC) at two intensities (90% and 120% of individual resting motor threshold (rMT)) on separate days. We assessed the pre-post stimulation BEN difference and its associations with neurotransmitter receptor and transporter binding maps. Our results showed that subthreshold iTBS (90% rMT) decreased striatal BEN, while suprathreshold iTBS (120% rMT) increased striatal BEN. We also found significant differences in the spatial correlation between BEN changes induced by different stimulation intensities and various neurotransmitters. These results suggest that differences in BEN caused by iTBS stimulation intensity may be related to the release of other neurotransmitters. The study underscores the significance of iTBS stimulation intensity and provides a basis for future clinical investigations to identify stimulation intensities with good therapeutic benefits.

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The influence of perceived stress and self-control on efficacy of repeated transcranial direct current stimulation in non-treatment-seeking smokers

Müller

Shevchenko

Gerhardt

et al. 2021

Drug and Alcohol Dependence

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Smoking-induced craving relief relates to increased DLPFC-striatal coupling in nicotine-dependent women

Cited by 5 publications

References 71 publications

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Intermittent theta burst stimulation (iTBS)-induced changes of resting-state brain entropy (BEN)

The influence of perceived stress and self-control on efficacy of repeated transcranial direct current stimulation in non-treatment-seeking smokers

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