Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA–Positive Women with Equivocal or Mildly Abnormal Cytology

McIntyre‐Seltman, Kathleen; Castle, Philip E.; Guido, Richard S.; Schiffman, Mark; Wheeler, Cosette M.

doi:10.1158/1055-9965.epi-04-0918

Cited by 115 publications

(88 citation statements)

References 31 publications

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“…Unlike most previous research in this field, our study showed that current cigarette smoking was not related to the risk of cervical cancer, while exposure to passive smoke seemed to be related to the risk of CIN 2/3. Although a consistent association between cigarette smoking and cervical cancer has been noted in numerous studies (22,23), the relationship between smoking and cervical cancer is difficult to prove. This is because of the strong confounding effect of sexual behavior, such as number of sexual partners and exposure to other sexually transmitted diseases.…”

Section: Discussionmentioning

confidence: 97%

Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study

Cho

Kim

Lee³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. Methods: The study population included women with histopathological diagnosis of cervical intraepithelial neoplasia (CIN) 1 (ns147), CIN 2/3 (ns177), cervical cancer (ns160), and a control group (ns378). Epidemiological data were collected and the serum concentrations of b-carotene, lycopene, zeaxanthin plus lutein, retinol, a-tocopherol, and g-tocopherol were

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Section: Discussionmentioning

confidence: 97%

Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study

Cho

Kim

Lee³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…Tobacco smoking is independently associated with risk of cervical cancer in case-control studies, and risk of cervical dysplasia among HPV-infected women increases with intensity and duration of tobacco use. [26][27][28] However, it remains unclear whether this increased risk is due solely to the independent genotoxic effects of tobacco-related carcinogens or whether tobacco exposure also affects the natural history of cervical HPV infection. Tobacco-related immune dysfunction might facilitate an incident HPV infection among exposed individuals, impede the ability to clear an infection, or facilitate reactivation of a latent infection.…”

Section: Discussionmentioning

confidence: 99%

Six‐month natural history of oral versus cervical human papillomavirus infection

D’Souza

Fakhry

Sugar

et al. 2007

Intl Journal of Cancer

157

138

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Human papillomavirus (HPV) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral HPV infection remains unexplored. The feasibility of studying oral HPV natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 HIV-positive and 63 HIV-negative participants. Cervical vaginal lavage samples were concurrently collected for comparison. HPV genomic DNA was detected in oral and cervical samples by consensus primer PCR and type-specified for 37 HPV types. The sixmonth cumulative prevalence of oral HPV infection was significantly less than for cervical infection (p < 0.0001). HIV-positive women were more likely than HIV-negative women to have an oral (33 vs. 15%, p 5 0.016) or cervical (78 vs. 51%, p < 0.001) infection detected. Oral HPV infections detected at baseline were as likely as cervical infections to persist to 6 months among HIVnegative (60% vs. 51%, p 5 0.70) and HIV-positive (55% vs. 63%, p 5 0.27) women. Factors that independently elevated odds for oral HPV persistence differed from cervical infection and included current smoking (OR 5 8, 95% CI 5 1.3-53), age above 44 years (OR 5 20, 95% CI 5 4.1-83), CD4 < 500 (OR 5 6, 95% CI 5 1.1-26), use of HAART therapy (OR 5 12, 95% CI 5 1.0-156), and time on HAART therapy (trend p 5 0.04). The rate of oral HPV infections newly detected at follow-up was significantly lower than cervical infection among HIV-positive (p < 0.001) and HIV-negative women (p < 0.001). Our study not only demonstrates that it is feasible to study the natural history of oral HPV infection with oral rinse sampling, but also indicates that oral and cervical HPV natural history may differ. ' 2007 Wiley-Liss, Inc.Key words: oral; HPV; natural history; comparison; cervical; human papillomavirus; infectionThe majority of oral cancers are attributable to alcohol and tobacco use, however a subset are etiologically associated with human papillomavirus (HPV) infection.1 Case-control studies have shown that oral HPV infection elevates risk of oral cancer, 2,3 and therefore is likely a prerequisite for cancer development. Although natural history studies of oral infection are yet to be performed, seropositivity to HPV16 increases risk for incident oral cancer, supporting a temporal association between infection and cancer risk. While the natural history of cervical HPV infection is well studied, it is unclear whether it is appropriate to extrapolate data from the cervical literature to oral HPV infection. Unfortunately, 2 studies with consecutive measures of oral HPV infection provide limited insight into its natural history. One study evaluated persistence of oral HPV infection at baseline and a subsequent two and a half year time-point among only 4 subjects. 5 In a study of husband-wife pairs, only overall HPV infection status was considered.6 Because analysis of type-specific HPV infection was not performed, meaningful estimates of incidence and clearance could not be obtained. Our study was designed ...

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“…20 Smokers are less likely to clear HPV infection and have an increased risk for cervical neoplasia. 21,22 Interesting correlates of vaccine acceptance were also seen when men's sexual history was examined. Men who were not currently sexually active were more likely to want the HPV vaccine.…”

Section: Discussionmentioning

confidence: 99%

Variables Associated With Human Papillomavirus (HPV) Vaccine Acceptance by Men

Ferris

Waller²,

Miller

et al. 2009

The Journal of the American Board of Family Medicine

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Objective: To determine correlates of human papillomavirus (HPV) vaccine acceptance for men.Methods: A convenience sample of men aged 18 to 45 years read a one-page information sheet about HPV and the HPV vaccine, then completed a 29-item questionnaire.2 tests were used to determine whether differences in demographic, sexual, and vaccine-related variables existed between levels of wanting the HPV vaccine.Results: Positive correlates of HPV vaccine acceptance included higher education (P < .0001); hispanic ethnicity (P ‫؍‬ .0003); wearing a seat belt most of the time (P ‫؍‬ .02); regular tobacco use (P ‫؍‬ <.001); not being sexually active (P ‫؍‬ .0008); history of more than 10 female sexual partners (P ‫؍‬ .0004); not having oral sex (P ‫؍‬ .045); extreme worry about vaccine side effects (P < .0001); extreme concern about vaccine safety (P < .0001); the importance of getting vaccines (P < .0001); familiarity with HPV (P < .0001); and extreme importance of receiving the HPV vaccine (P < .0001).Conclusions In 2006, the US Food and Drug Administration (FDA) approved the quadrivalent human papillomavirus (HPV, types 6/11/16 and 18) L1 virus-like particle vaccine. This prophylactic vaccine prevents cervical, vaginal, vulvar, and perianal neoplasias, including anogenital condylomata.1-4 Based on epidemiologic data, the vaccine should reduce the incidence of cervical cancer by 70% and genital warts by 90%. Universal protection is afforded when administered to people not previously exposed to the HPV types covered by the vaccine. Currently, the vaccine is approved for use in 9-to 26-year-old girls and women.Many low-risk and high-risk types of HPV can also infect various anatomic sites in boys and men. 5The low-risk types of HPV cause recurrent respiratory papillomatosis or condylomata of the nasopharynx. 6,7 Anogenital warts are also caused by low-risk HPV types 6 and 11. High-risk HPV types cause precancers and cancer of the penis and anus.8 -13 HPV 16, a particularly virulent type, causes head and neck cancer.14,15 Just as with women, men experience significant morbidity and potential mortality from HPV-related diseases.Women clearly benefit from receiving the HPV vaccine. One would assume men could also benefit by being vaccinated against low-and high-risk HPV types. Correlates of HPV vaccine acceptance have been identified for mid-adult women.16 However, correlates of HPV vaccine acceptance among men have not been described. The purpose of these analyses were to determine correlates of HPV vaccine acceptance among men. Methods PopulationA convenience sample of 18-to 45-year-old men were recruited to participate in our study. Subjects were enrolled at various places in Augusta and Atlanta, Georgia, including a local military base, college campuses, fire stations, a university-based family medicine center waiting room, and from elsewhere in the community. Inclusion criteria included an interest to complete a brief questionnaire; being a man; 18-to 45-years-old; and an This article was externally peer reviewed.

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Smoking Is a Risk Factor for Cervical Intraepithelial Neoplasia Grade 3 among Oncogenic Human Papillomavirus DNA–Positive Women with Equivocal or Mildly Abnormal Cytology

Cited by 115 publications

References 31 publications

Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study

Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study

Six‐month natural history of oral versus cervical human papillomavirus infection

Variables Associated With Human Papillomavirus (HPV) Vaccine Acceptance by Men

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