Smoking, nicotine and neuropsychiatric disorders

Döme, Péter; Lazáry, Judit; Kalapos, Miklös Péter; Rihmer, Zoltán

doi:10.1016/j.neubiorev.2009.07.013

Cited by 199 publications

(146 citation statements)

References 943 publications

(1,431 reference statements)

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…Specifically, elevated average smoking rates 460% have been reported in patients suffering from schizophrenia (Dome et al, 2010). Different theories implicate nicotine intake via smoking as a compensatory strategy used by schizophrenia patients to ameliorate their symptoms (D'Souza and Markou, 2012).…”

Section: Introductionmentioning

confidence: 99%

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Strube

Bunse

Nitsche

et al. 2014

Neuropsychopharmacol

View full text Add to dashboard Cite

Impaired neuroplastic responses following noninvasive brain stimulation have been reported repeatedly in schizophrenia patients. These findings have been associated with deficits in GABAergic, glutamatergic, and cholinergic neurotransmission. Although various neurophysiological studies have indicated a relationship between nicotine and neuroplasticity in healthy individuals, the present study is the first investigation into the impact of nicotine on LTD-like plasticity in patients with schizophrenia. Cortical excitability and cortical plasticity were explored in 30 schizophrenia patients (17 smoker, 13 nonsmoker) and 45 healthy controls (13 smoker, 32 nonsmoker) by using single-pulse transcranial magnetic stimulation (TMS) before and following cathodal transcranial direct current stimulation (tDCS) applied to the left primary motor cortex. Our analysis revealed abolished LTD-like plasticity in nonsmoking schizophrenia patients. However, these plasticity deficits were not present in smoking schizophrenia patients. In healthy controls, significant MEP reductions following cathodal tDCS were observed in nonsmoking individuals, but only trend-level reductions in smokers. In smoking schizophrenia patients, the severity of negative symptoms correlated positively with reduced neuroplasticity, whereas nonsmoking patients displayed the opposite effect. Taken together, the data of our study support the notion of an association between chronic smoking and the restitution of impaired LTD-like plasticity in schizophrenia patients. Although replication and further research are needed to better understand this relationship, our findings indicate that nicotine intake might stabilize the impaired inhibition-facilitation balance in the schizophrenic brain through a complex interaction between cortical plasticity, and GABAergic and cholinergic neurotransmission, and might explain the reduced prevalence of negative symptoms in this population.

show abstract

Section: Introductionmentioning

confidence: 99%

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Strube

Bunse

Nitsche

et al. 2014

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…1 Nevertheless, this compound has a wide range of uses in therapeutics, 1 insecticides 2 and formation of polymers. 3 The biological activity of nicotine, an agonist of the nicotine acetylcholine receptor protein, depends on its molecular shape, since active sites in receptors and enzymes would interact only with molecules of the correct conformation.…”

Section: Introductionmentioning

confidence: 99%

Rapid probe of the nicotine spectra by high-resolution rotational spectroscopy

Grabow

Mata

Alonso

et al. 2011

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

Nicotine has been investigated in the gas phase and two conformational forms were characterized through their rotational spectra. Two spectroscopic techniques have been used to obtain the spectra: a new design of broadband Fourier transform microwave (FTMW) spectroscopy with an in-phase/quadrature-phase-modulation passage-acquired-coherence technique (IMPACT) and narrowband FTMW spectroscopy with coaxially oriented beam-resonator arrangement (COBRA). The rotational, centrifugal distortion and hyperfine quadrupole coupling constants of two conformers of nicotine have been determined and found to be in N-methyl trans configurations with the pyridine and pyrrolidine rings perpendicular to one another. The quadrupole hyperfine structure originated by two 14 N nuclei has been completely resolved for both conformers and used for their unambiguous identification.

show abstract

“…A study by de Leon et al [7] and Gurpegui et al [8] has shown that in adults (over twenty years old) who are in the group of increased susceptibility to schizophrenia, or are already suffering from the disease there is a significantly higher risk of taking up smoking than among the general population [9]. No wonder then that the problem of nicotine addiction and its consequences is becoming more and more urgent in clinical psychiatry.…”

Section: Scope Of Phenomenonmentioning

confidence: 99%

1784 – The characteristics of nicotine addiction among patients with schizophrenia

Wojtyna

Wiszniewicz

2013

European Psychiatry

View full text Add to dashboard Cite

IntroductionNicotine addiction is common among people with schizophrenia and is associated with significant morbidity and mortality. This rate is a much higher than among the general population, where the percentage of smokers varies between 25-47%.AimsThis study aims to characterize nicotine dependence in schizophrenics compared to smokers not having mental health problems. The research was also to determine whether the affective psychological factors (anxiety and depression) and the level of distress are important predictors of smoking in a group of psychotic patients.Methods204 smokers participated in the research, including 104 people with schizophrenia and 100 healthy persons. Participants were interviewed and asked to complete five questionnaires: Fagerström Test for Nicotine Dependence, Test of Motivation for Smoking Cessation, Hospital Anxiety and Depression Scale and Distress Thermometer.ResultsThe study has shown that the schizophrenics smoked more, took a greater number of puffs, showed a higher level of dependence and were less motivated to give up smoking than the mentally healthy persons. The results show the important role of affective factors and feeling of distress in nicotine dependence. The study also confirmed a significant relationship between distress and the number of cigarettes smoked. Affective factors and distress explain 34% of variance of the number of cigarettes in the group of schizophrenics and 56% in the control group.ConclusionsThis study showed that psychological treatment should be implemented into programs for nicotine dependence to improve the functioning schizophrenics in terms of coping with stress and maintaining good mood.

show abstract

Smoking, nicotine and neuropsychiatric disorders

Cited by 199 publications

References 943 publications

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Rapid probe of the nicotine spectra by high-resolution rotational spectroscopy

1784 – The characteristics of nicotine addiction among patients with schizophrenia

Contact Info

Product

Resources

About