Smoking status, occupational asbestos exposure and bronchial location of lung cancer

Paris, Christophe; Bénichou, Jacques; Saunier, F; Metayer, J; Brochard, Patrick; Thiberville, Luc; Nouvet, G

doi:10.1016/s0169-5002(02)00538-x

Cited by 23 publications

(17 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies mention tumor preference for the upper lobe but, despite the fact that the majority of the patients studied were smokers, do not clearly associate it with the smoking habit, giving more weight to correlations with asbestos exposure and diet. (6)(7)10) In Brazil, ours was the first group to make this correlation with a large number of patients. One limitation of this study is that the data were retrospective, and the population of nonsmokers was small.…”

Section: Discussionmentioning

confidence: 79%

“…It can be hypothesized that there is less efficient delivery of food derivatives or protective substances via circulation to the upper lobes, when compared with the lower lobes. (7,10) All of this takes place because the ventilation/ perfusion ratio is greater in the upper lobe than in the lower lobe, creating favorable conditions for this predominance in smokers. (7,10) The decreased forced expiratory volume in one second increases the risk of lung cancer, and risk increases in parallel with decreasing function.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we studied the location of lung tumors, comparing nonsmokers and smokers, as well as looking for gender-related differences. (6)(7)(8)(9) …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Localização do carcinoma pulmonar em relação ao vício tabágico e ao sexo

2006

View full text Add to dashboard Cite

Objective: To analyze the locations of lung carcinomas in relation to patient gender and smoking status. Methods: In order to test the hypothesis that lung carcinoma location (upper or lower lobe; left or right side) is correlated with smoking status and gender, we conducted a retrospective study of 697 patients with bronchogenic carcinoma treated at the Pulmonology-Oncology Outpatient Clinic of the Federal University of São Paulo. Results: We found that the bronchogenic carcinomas occurring in smokers were more frequently located in the upper lobes, whereas those occurring in nonsmokers were more frequently located in the lower lobes. In women, the neoplasms were more often seen in the lower lobes, especially in nonsmokers. Based on the available data, there were no differences in terms of the side affected (left or right). Conclusion: Overall, bronchogenic carcinomas are predominantly found in the upper lobes. However, in nonsmokers, they occur more frequently in the lower lobes. In females, bronchogenic carcinomas present a tendency to occur more often in the lower lobes.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Localização do carcinoma pulmonar em relação ao vício tabágico e ao sexo

2006

View full text Add to dashboard Cite

show abstract

“…In humans, lung cancer and bronchogenic carcinoma are synonymous because most cancers occur in the large bronchi (29,30). These tumors may be adenocarcinoma, squamous carcinoma, large-cell anaplastic carcinoma, or small-cell carcinoma, and are preceded by dysplasias that have the same bronchial distribution (31,32).…”

Section: Discussionmentioning

confidence: 99%

Loss of Nkx2.8 Deregulates Progenitor Cells in the Large Airways and Leads to Dysplasia

et al. 2006

View full text Add to dashboard Cite

Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon was replaced by a LacZ marker gene joined to the intact 5 ¶-untranslated region. Marker expression was observed throughout the lower respiratory tract, beginning on E11 in a few cells of the distal lung buds. The region of expression then spread upward. By neonatal day 1, expression was greatest in the large airways and the Nkx2.8À/À mice exhibited generalized tracheobronchial hyperplasia. Bromodeoxyuridine (BrdUrd) labeling studies showed that a higher rate of bronchial cell proliferation persisted at 6 to 8 months. In adults, Nkx2.8 marker expression decreased with progressive differentiation into ciliated and secretory cells. The cell localizations and patterns of coexpression with BrdUrd and differentiation markers suggest a progenitor relationship: the cells that most strongly express Nkx2.8 seem to function as tracheobronchial stem cells. Moreover, Nkx2.8 acts to limit the number of these progenitor cells because the marker-expressing population was greatly expanded in Nkx2.8À/À mice. Increased proliferation and an altered progenitor relationship caused progressive bronchial pathology, which manifested as widespread dysplasia in the large airways of 1-year-old Nkx2.8À/À mice.

show abstract

“…An important factor not considered in this study is the occupational exposure to asbestos related to shipbuilding [22], which is associated with increased risks of mesotheliomas and ADK [23,24]. Thirdly, no information was available about the daily time spent in each risk area and if sex-specific differences were present.…”

Section: Discussionmentioning

confidence: 99%

Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study, 1995–2009

Collarile¹,

Bidoli²,

Barbone³

et al. 2017

Preprint

View full text Add to dashboard Cite

Abstract:We assessed lung and bladder cancer risk in people living near a coal-oil-fired thermal power plant in an area of north-eastern Italy covered by a population-based cancer registry. Incidence rate ratios (IRR) by sex, age, and histology were computed according to tertiles of residential exposure to benzene, nitrogen dioxide (NO2), particular matter (PM10), and sulfur dioxide (SO2) among 1076 incident cases of lung and 650 cases of bladder cancers. In men of all ages and in women under 75 years of age, no significant associations were observed. Conversely, in women aged ≥ 75 years significantly increased risks of lung and bladder cancer were related to high exposure to benzene (IRR for highest vs. lowest tertile: 2.00 for lung cancer and 1.94 for bladder cancer) and NO2 (IRR: 1.72 for lung cancer; and 1.94 for bladder cancer). In these women, a 1.71-fold higher risk of lung cancer was also related to high exposure to SO2. The findings of this descriptive study indicate that air pollution may have a role with regard to the risk of lung and bladder cancers, limited to women aged ≥ 75 years. Such increased risk warrants further analytical investigations.

show abstract

Smoking status, occupational asbestos exposure and bronchial location of lung cancer

Cited by 23 publications

References 47 publications

Localização do carcinoma pulmonar em relação ao vício tabágico e ao sexo

Localização do carcinoma pulmonar em relação ao vício tabágico e ao sexo

Loss of Nkx2.8 Deregulates Progenitor Cells in the Large Airways and Leads to Dysplasia

Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study, 1995–2009

Contact Info

Product

Resources

About