Smoking Tobacco and Gastrointestinal Pathophysiology and Diseases

Asakura, Hitoshi

doi:10.1002/9783527635320.ch12

Cited by 1 publication

(1 citation statement)

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“…The chemical compounds in both phases are the result of chemical processes occurring at high temperature and involving the different ingredients of the cigarette (tobacco, additives and paper) . The toxicity of the cigarette smoke is directly correlated with its chemical composition . Three types of cigarette smoke have to be considered.…”

Section: Introductionmentioning

confidence: 99%

Study of the mainstream cigarette smoke aerosols by Fourier transform ion cyclotron resonance mass spectrometry coupled to laser/desorption and electrospray ionization – Additional insights on the heteroaromatic components

Kamissoko

Carré

Schramm

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale:The chemical composition of the particulate phase of cigarette smoke inhaled by the active smoker is still poorly known in spite of its importance from a health point of view. A non-targeted approach is applied to cigarette smoke particles collected on a quartz filter to obtain an as complete as possible description of this complex mixture.Methods: A home-made smoking machine including devices for volatile organic compounds (VOCs) and particle sampling was used. The validation of the cigarette smoking and cigarette smoke collection procedures was conducted by the quantification of some compounds by gas chromatography/mass spectrometry (GC/MS). The particles were investigated by Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) directly after their collection on quartz filters by laser/desorption ionization (LDI) or after extraction with CH 2 Cl 2 by electrospray ionization (ESI). Results: The determination of the benzene, toluene, ethylbenzene and xylenes (from 2 to 35 μg/cigarette) and nicotine (0.68 ± 0.05 mg/cigarette) validated the used sampling method. The complementarity of the LDI and ESI sources for the cigarette smoke analysis was established. The ESI analyses evidenced polar compounds and components with a pyridine group and LDI ensured the detection of polycondensed heteroaromatic species. Finally, this methodology was employed to characterize particles from cigarettes with or without flavoring additives. Conclusions: Some insights into the composition of cigarette smoke inhaled by active smokers have been obtained. The~1750 observed features revealed the huge complexity of cigarette smoke particles and the diversity of the possible associated health issues. Both heteroaromatic and highly oxygenated compounds produced by combustion and pyrolysis have been highlighted.

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Section: Introductionmentioning

confidence: 99%