2005
DOI: 10.1016/j.lungcan.2005.04.004
|View full text |Cite
|
Sign up to set email alerts
|

Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
19
0

Year Published

2008
2008
2012
2012

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 41 publications
(21 citation statements)
references
References 24 publications
2
19
0
Order By: Relevance
“…However, a recent study found no association between this variation and breast cancer risk in a European population (Kuschel et al, 2002). Interestingly, the rs1805794 GG genotype was demonstrated to be associated with risk of lung cancer instead of the GC or CC genotype in a Chinese study (Lan et al, 2005). Our present study also supported that NBS1 rs1805794 C/G variant genotypes are related to increased risk of HCC.…”
Section: Discussionsupporting
confidence: 76%
“…However, a recent study found no association between this variation and breast cancer risk in a European population (Kuschel et al, 2002). Interestingly, the rs1805794 GG genotype was demonstrated to be associated with risk of lung cancer instead of the GC or CC genotype in a Chinese study (Lan et al, 2005). Our present study also supported that NBS1 rs1805794 C/G variant genotypes are related to increased risk of HCC.…”
Section: Discussionsupporting
confidence: 76%
“…The genes included in the prediction model have biological plausibility. Two of the five genes whose sequence variation is associated with methylation, NBN and XRCC3, have shown association with lung cancer (18,27). SNPs within the DNA-PKc and CHEK2 genes have been associated with breast and other cancers, whereas no studies have been conducted with MRE11A (19,28).…”
Section: Resultsmentioning
confidence: 99%
“…In assigning a prior probability for these genes, we considered the strong association between DSBRC and risk for promoter methylation and the stringent r 2 value (0.8) for selecting tag SNPs. Based on the evidence for associations between SNPs in CHEK2, XRCC3, DNA-PKc, NBN, LIG4, and XRCC2 and several cancers (18)(19)(20)(21)(22)(23)(24)(25), we assigned a relatively high prior probability range (0.1-0.25) for SNPs of these six genes. In contrast, for MRE11A, Ku80, RAD50, and CHEK1, a relatively low prior probability range (0.01-0.1) was assigned because there are no studies that have addressed the association of variants within these genes to cancer.…”
Section: Cancer Researchmentioning
confidence: 99%
“…Publications on NBS1 polymorphisms have mainly focused on rs1805794 and the risk of cancers including lung, breast, bladder, renal cell cancers, non-Hodgkin lymphoma and childhood acute leukemia (Medina et al, 2003;Lan et al, 2005;Zienolddiny, 2005;Landi et al, 2006;Ryk et al, 2006;Hsu et al, 2007;Choudhury et al, 2008;Margulis et al, 2008;Mosor et al, 2008;Schuetz et al, 2009;Stern et al, 2009;Park et al, 2010), but the results were not consistent. A recent meta-analysis on rs1805794 has shed light on a positive association between the variant genotype of rs1805794 and the risk of multiple cancers (MeiXia et al, 2009).…”
Section: 851 Variants Of Nbs1 Predict Clinical Outcome Of Chemotheramentioning
confidence: 99%
“…Rs1805794 located in exon 5 of NBS1 is one of the most common polymorphisms and can induce an amino acid substitution from Glu to Gln. Studies have investigated the association between rs1805794 and risk of multiple cancers, such as lung, breast, bladder and nasopharyngeal carcinoma (Medina et al, 2003;Lan et al, 2005;Lu et al, 2006;Hsu et al, 2007;Stern et al, 2009;Zheng et al, 2011). However, only one study has explored the effect of this polymorphism on prognosis of human cancer and reported that it was not associated with the survival of esophagus or gastric adenocarcinoma after platinum-based neoadjuvant poly-chemotherapy (Ott et al, 2011).…”
Section: Introductionmentioning
confidence: 99%