Native fescue grassland degradation and reductions in plant species diversity due to smooth brome (Bromus inermis Leyss.) invasion and dominance have far ranging consequences for both human and ecological systems. A study was undertaken to reduce smooth brome which was invading foothills fescue grassland in Canada and displacing native species. Sheep and cattle grazing, mowing, glyphosate, and burning were applied to control smooth brome-dominant grasslands over three growing seasons. Defoliation (5 to 10 cm, 2 to 4 times) did not reduce smooth brome tiller density, etiolated regrowth, or total non-structural carbohydrates; however, the three heaviest defoliation treatments (sheep 3×, cattle 3×, mowing 4×) reduced smooth brome composition by year 3. Repeated glyphosate wicking (1× year 1, 2× year 2) was the most effective treatment and reduced smooth brome tiller density by 50% by year 3. Early-spring burning, as smooth brome began to grow, stressed the plants and reduced tiller density. Kentucky bluegrass (Poa pratensis L.), the subdominant species, increased in all treatments except the reference; thus, reducing smooth brome may result in another undesirable species becoming dominant.