Smooth Muscle Relaxing Flavonoids and Terpenoids from<i>Conyza filaginoides*</i>

Mata, Rachel; Rojas, Antonio; Acevedo, Laura; Estrada, Samuel; Calzada, Fernando; Rojas, I.; Bye, Ragnar; Linares, Edelmira

doi:10.1055/s-2006-957598

Cited by 55 publications

(36 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, α-spinasterol strongly contributed to the antinociceptive effect of P. sabulosa HE. The proposed mechanism of action likely involves a disruption on glutamatergic pathways and calcium movement [9,34].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effect of the Polygala sabulosa Hydroalcoholic Extract in Mice: Evidence for the Involvement of Glutamatergic Receptors and Cytokine Pathways

Ribas

Meotti²,

Nascimento³

et al. 2008

Basic Clin Pharma Tox

View full text Add to dashboard Cite

This study investigated the role of the glutamatergic system on the antinociception caused by Polygala sabulosa hydroalcoholic extract (HE). The systems mediated by substance P, capsaicin, interleukin-1 β (IL-1 β ) and tumour necrosis factor-α (TNF-α ) were also investigated. P. sabulosa HE given orally produced a significant inhibition of glutamateinduced paw licking ) mg/kg and inhibition of 79 ± 6% at 1000 mg/kg]. The plant derivatives α -spinasterol, scopoletin and styryl-2-pyrones (compound 1 and 3) (10 mg/kg, intraperitoneally) inhibited 80 ± 7%, 46 ± 11%, 45 ± 11% and 35 ± 13% the nociceptive response caused by glutamate, respectively. Furthermore, P. sabulosa HE (500 mg/kg, orally) caused marked inhibition of nociceptive response induced by intrathecal injection of glutamate, N-methyl-d -aspartic acid, α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, TNF-α and IL-1 β , with inhibitions of 44 ± 7%, 55 ± 4%, 38 ± 10%, 61 ± 7%, 76 ± 9% and 100%, respectively. In contrast, P. sabulosa HE (500 mg/kg, orally) did not affect the biting response induced by the metabotropic glutamatergic receptor agonist (±)-1-aminocyclopentanetrans -1,3-dicarboxylic acid, substance P and capsaicin. The locomotor activity was altered only in mice treated with a very high dose (1000 mg/kg) of P. sabulosa HE. Our results showed that the antinociceptive effects of P. sabulosa HE are associated with an inhibition of glutamatergic transmission and an inhibition of pathways dependent on pro-inflammatory cytokines. The plant derivatives α -spinasterol, scopoletin and styryl-2-pyrones play an important role on the antinociceptive effects of P. sabulosa HE.The plants of genus Polygala are widely distributed in Santa Catarina state, Brazil, and have been employed to treat disorders of the bowel and kidney, as a topical anaesthetic and expectorant [1]. Scientific studies in isolated cells and in animals have confirmed the biological activities of the plants from genus Polygala [2-10]. The chemical constituents of Polygala , coumarins, steroids, saponins, lignans, flavonoids and xanthones confer to these plants valuable pharmacological properties [7][8][9][10][11][12][13].Recently, we have demonstrated that Polygala sabulosa hydroalcoholic extract (HE) A. W. Bennett (Polygalaceae) produced antinociceptive action against the acetic acidinduced visceral nociception. The presence of styryl-2-pyrones, coumarin (scopoletin) and steroid ( α -spinasterol) gives to the plant a potent antinociceptive effect [9]. However, the model of nociception previously employed did not allow to clearly identify the mechanism of the antinociceptive action of the plant extract. Indeed, the acetic acid-induced visceral nociception involves a chain of inflammatory mediators that are released into the abdominal cavity and in the central nervous system [14][15][16].In this concern, the aim of this study was to identify the mechanism by which P. sabulosa HE exerts its antinociceptive effect. For this purpose, the effects of the P. sabulosa HE we...

show abstract

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effect of the Polygala sabulosa Hydroalcoholic Extract in Mice: Evidence for the Involvement of Glutamatergic Receptors and Cytokine Pathways

Ribas

Meotti²,

Nascimento³

et al. 2008

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…Scientific investigations using different pharmacological tests are performed to prove their potential efficiency. That used the evaluation of antispasmodic activity on some isolated organs have demonstrated that some of these medicinal plant species possess significant and interesting spasmolytic (Mata et al, 1997;Trute et al, 1997;Sadraei et al, 2003;Cortés et al, 2006;Cechinel-Filho et al, 2007) or spasmogenic (Gilani et al, 2005(Gilani et al, , 2007 activity. In some cases, mechanisms underling the antispasmodic activity of tested extracts are also reported (Gilani et al, 2005(Gilani et al, , 2006(Gilani et al, , 2007(Gilani et al, , 2008.…”

Section: Introductionmentioning

confidence: 99%

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Cimanga

Mukenyi

Kambu

et al. 2010

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Flavonoids are well known for their spasmolytic activity (Williamson et al, 1998). Most spasmolytic flavonoids in the literature contain a flavone (Hazekamp et al, 2001), flavonol (Bergendorff and Sterner, 1995), isoflavone and flavanone skeleton (Rojas et al, 1996;Mata et al, 1997). The flavonoids isolated from S. samarangense have a chalcone and flavanone skeleton.…”

Section: Introductionmentioning

confidence: 99%

Presence of calcium antagonist activity explains the use ofSyzygium samarangense in diarrhoea

et al. 2006

View full text Add to dashboard Cite

Syzygium samarangense (Family; Myrtaceae) or 'makopa', as it is commonly known, is native to Malaysia, some islands of Indonesia and to Far East in general. This study was undertaken to rationalize the use of this plant in hypermotility states of the gut. The hexane extract of S. samarangense (Ss.Hex) was found to dose-dependently (10-3000 microg/mL) relax the spontaneously contracting isolated rabbit jejunum. When tested for a possible calcium channel blocking (CCB) activity, the extract (10-1000 microg/mL) relaxed the high K+-induced contractions and also decreased the Ca++ dose-response curves in a dose-dependent manner (30-100 microg/mL), confirming the CCB activity. Four flavonoids isolated from the hexane extract were tested for a possible spasmolytic activity. All flavonoids, identified as: 2'-hydroxy-4',6'-dimethoxy-3'-methylchalcone (SS1), 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (SS2), 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (SS3) and 7-hydroxy-5-methoxy-6,8-dimethylflavanone (SS4), showed dose-dependent (10-1000 microg/mL) spasmolytic activity with SS2 being the most potent. These results indicate that the presence of compounds with spasmolytic and calcium antagonist activity may be responsible for the medicinal use of the plant in diarrhoea.

show abstract

Smooth Muscle Relaxing Flavonoids and Terpenoids fromConyza filaginoides*

Cited by 55 publications

References 6 publications

Antinociceptive Effect of the Polygala sabulosa Hydroalcoholic Extract in Mice: Evidence for the Involvement of Glutamatergic Receptors and Cytokine Pathways

Antinociceptive Effect of the Polygala sabulosa Hydroalcoholic Extract in Mice: Evidence for the Involvement of Glutamatergic Receptors and Cytokine Pathways

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Presence of calcium antagonist activity explains the use ofSyzygium samarangense in diarrhoea

Contact Info

Product

Resources

About