Let $\mathcal {X}$ be a Banach space with a fundamental biorthogonal system, and let $\mathcal {Y}$ be the dense subspace spanned by the vectors of the system. We prove that $\mathcal {Y}$ admits a $C^\infty $-smooth norm that locally depends on finitely many coordinates (LFC, for short), as well as a polyhedral norm that locally depends on finitely many coordinates. As a consequence, we also prove that $\mathcal {Y}$ admits locally finite, $\sigma $-uniformly discrete $C^\infty $-smooth and LFC partitions of unity and a $C^1$-smooth locally uniformly rotund norm. This theorem substantially generalises several results present in the literature and gives a complete picture concerning smoothness in such dense subspaces. Our result covers, for instance, every weakly Lindelöf determined Banach space (hence, all reflexive ones), $L_1(\mu )$ for every measure $\mu $, $\ell _\infty (\Gamma )$ spaces for every set $\Gamma $, $C(K)$ spaces where $K$ is a Valdivia compactum or a compact Abelian group, duals of Asplund spaces, or preduals of Von Neumann algebras. Additionally, under Martin Maximum MM, all Banach spaces of density $\omega _1$ are covered by our result.