Given smooth manifolds M1, . . . , Mn (which may have a boundary or corners), a smooth manifold N modeled on locally convex spaces and α ∈ (N0 ∪ {∞}) n , we consider the setthe sense of Alzaareer. Such mappings admit, simultaneously, continuous iterated directional derivatives of orders ≤ αj in the jth variable for j ∈ {1, . . . , n}, in local charts. We show that C α (M1 × • • • × Mn, N ) admits a canonical smooth manifold structure whenever each Mj is compact and N admits a local addition. The case of non-compact domains is also considered.