SN38 conjugated hyaluronic acid gold nanoparticles as a novel system against metastatic colon cancer cells

Hosseinzadeh, Hosniyeh; Atyabi, Fatemeh; Varnamkhasti, Behrang Shiri; Hosseinzadeh, Reza; Ostad, Seyed Nasser; Ghahremani, Mohammad Hossein; Dinarvand, Rassoul

doi:10.1016/j.ijpharm.2017.04.060

Cited by 52 publications

(24 citation statements)

References 52 publications

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“…Moreover, for CS-NPs ( Fig. 4C; 5B, C and D), the amino band is shifted from 1652.5 467 to ~1570 cm -1 , confirming that amino groups of CS were involved in the cross-linking by 468 phosphate (TPP) [49]. This shifting was confirmed by analyzing the spectrum of unloaded CS-469…”

Section: Ft-ir Analysis 461mentioning

confidence: 56%

“…4C), a stretching 477 band from 2860 to 2950 cm -1 confirms the incorporation of poloxamer 188. The same strong 478 peak appears for pure poloxamer, which represents the stretching vibrational band of methylene 479 group [49,65]. Finally, for 77KS, two strong bands at 1550 cm -1 and 1414 cm -1 represents the 480 carboxylate ion present in the molecule (Fig.…”

Section: Ft-ir Analysis 461mentioning

confidence: 88%

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PEGylated and poloxamer-modified chitosan nanoparticles incorporating a lysine-based surfactant for pH-triggered doxorubicin release

Scheeren

Nogueira

Macedo

et al. 2016

Colloids and Surfaces B: Biointerfaces

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28The growing demand for efficient chemotherapy in many cancers requires novel approaches in 29 target-delivery technologies. Nanomaterials with pH-responsive behavior appear to have 30 potential ability to selectively release the encapsulated molecules by sensing the acidic tumor 31 microenvironment or the low pH found in endosomes. Likewise, polyethylene glycol (PEG)-32 and poloxamer-modified nanocarriers have been gaining attention regarding their potential to 33 improve the effectiveness of cancer therapy. In this context, DOX-loaded pH-responsive 34 nanoparticles (NPs) modified with PEG or poloxamer were prepared and the effects of these 35 modifiers were evaluated on the overall characteristics of these nanostructures. Chitosan and 36 tripolyphosphate were selected to form NPs by the interaction of oppositely charged 37 compounds. A pH-sensitive lysine-based amphiphile (77KS) was used as a bioactive adjuvant. 38The strong dependence of 77KS ionization with pH makes this compound an interesting 39 candidate to be used for the design of pH-sensitive devices. The physicochemical 40 characterization of all NPs has been performed, and it was shown that the presence of 77KS 41 clearly promotes a pH-triggered DOX release. Accelerated and continuous release patterns of 42 DOX from CS-NPs under acidic conditions were observed regardless of the presence of PEG 43 or poloxamer. Moreover, photodegradation studies have indicated that the lyophilization of NPs 44 improved DOX stability under UVA radiation. Finally, cytotoxicity experiments have shown 45 the ability of DOX-loaded CS-NPs to kill HeLa tumor cells. Hence, the overall results suggest 46 that these pH-responsive CS-NPs are highly potent delivery systems to target tumor and 47 intracellular environments, rendering them promising DOX carrier systems for cancer therapy. 48 Keywords: chitosan nanoparticles; doxorubicin; in vitro release; in vitro cytotoxicity; lysine-49 based surfactant; pH-sensitivity 50

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Section: Ft-ir Analysis 461mentioning

confidence: 56%

Section: Ft-ir Analysis 461mentioning

confidence: 88%

PEGylated and poloxamer-modified chitosan nanoparticles incorporating a lysine-based surfactant for pH-triggered doxorubicin release

Scheeren

Nogueira

Macedo

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…CS is a biocompatible and biodegradable polymer with low toxicity and immunogenicity so the researchers were interested to using them as NPs [49,50]. Chitosans based nanoparticles [63,58,64]. Chemotherapy is a routine method to suppress the tumor cells.…”

Section: Chitosanmentioning

confidence: 99%

Untitled

Deljoo

Rabiee

2019

Asian J. Nanosci. Mater.

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Extensive studies on curcumin have improved that it has certain therapeutic impact for different kinds of diseases such as cancer. Regardless of its positive features, its application is hampered by its low water solubility, bioavailability, and low cellular uptake. During recent years, several ways have been developed to protect curcumin from degradation and increase the capacity of targeting unhealthy cells. The progress in nanotechnology encouraged nanotechnologists to formulate nanoparticles encapsulating curcumin, such as polymer nanoparticles, solid nanoparticles, liposome/lipid nanoparticles, micelles, dendrimers, polymer conjugates, etc. to enhance sustained release of curcumin at target cells and to improve curcumin bioavailability. Nowadays, newer formulations of nanoparticles as called Hybrid nanoparticles are designed in order to achieve efficient and specific curcumin targeted compound that result in the improved therapeutic efficacy of curcumin with high biocompatibility associated with aptamers, folic acid, chitosan coated halloysite loaded with curcumin-Au hybrid nanoparticle etc. This review describes a number of formulated hybrid nanoparticles and their efficacy in specific targeting to cancerous cells.

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“…The aforementioned characteristics as well as its high viscoelasticity and potential for chemical modifications to the backbone structure, all make HA an ideal candidate for anticancer applications involving engineered gold-based nanomaterials [42]. Many research works present different synthesis processes of HA-GNP complexes [43] as well as their in vitro testing as drug carriers for photothermal cytotoxic drug release in cancer cells [44]. We identified certain studies involving pre-clinical cancer models, however the HA coated GNPs are only administered systemically, and biodistribution is not evaluated [45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer

Terracciano

Carcamo-Bahena

Butler

et al. 2021

Preprint

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Biofouling is the unwanted adsorption of cells, proteins, or intracellular and extracellular bio-molecules that can spontaneously occur on the surface of metal nanocomplexes. It represents a major issue in bioinorganic chemistry because it leads to the creation of a protein corona, which can destabilize a colloidal solution and result in undesired macrophage-driven clearance, consequently causing failed delivery of a targeted drug-cargo. Hyaluronic acid (HA) is a bioactive, natural mucopolysaccharide with excellent antifouling properties, arising from its hydrophilic and polyanionic characteristics in physiological environments which prevent opsonization. In this study, hyaluronate-thiol (HA-SH) (MW 10 kDa) was used to surface-passivate gold nanoparticles (GNPs) synthesized using a citrate reduction method. HA functionalized GNP complexes (HA-GNPs) were characterized using absorption spectroscopy, scanning electron microscopy, zeta potential, and dynamic light scattering. GNP cellular uptake and potential dose-dependent cytotoxic effects due to treatment were evaluated in vitro in HeLa cells using ICP-OES and Trypan blue and MTT assays. Further, we quantified the in vivo biodistribution of intratumorally injected HA functionalized GNPs in Lewis Lung carcinoma (LLC) solid tumors grown on the flank of C57BL/6 mice and compared localization and retention with nascent particles. Our results reveal that HA-GNPs show overall greater peritumoral distribution (**p<0.005, 3 days post-intratumoral injection) than citrate-GNPs with reduced biodistribution in off-target organs. This property represents an advantageous step forward in localized delivery of metal nano-complexes to the infiltrative region of a tumor, which may improve the application of nanomedicine in the diagnosis and treatment of cancer.

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SN38 conjugated hyaluronic acid gold nanoparticles as a novel system against metastatic colon cancer cells

Cited by 52 publications

References 52 publications

PEGylated and poloxamer-modified chitosan nanoparticles incorporating a lysine-based surfactant for pH-triggered doxorubicin release

PEGylated and poloxamer-modified chitosan nanoparticles incorporating a lysine-based surfactant for pH-triggered doxorubicin release

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Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer

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