SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells

Hwang, Wei–Lun; Yang, Muh‐Hwa; Tsai, Ming–Long; Lan, Hsin–Yi; Su, Shu–Han; Chang, Shih Ching; Teng, Hao–Wei; Yang, Shung‐Haur; Lan, Yuan–Tzu; Chiou, Shih‐Hwa; Wang, Hsei‐Wei

doi:10.1053/j.gastro.2011.04.008

Cited by 269 publications

(229 citation statements)

References 52 publications

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“…In fact, simply overexpressing certain oncogenic molecules (e.g., Nanog, CD44, Twist, hTERT, etc) is sufficient to reprogram primary non-tumorigenic cells or bulk cancer cells into stem-like cancer cells [136][137][138][139][140][141]. These latter observations [136][137][138][139][140][141] are consistent with the observations that such 'stemness' molecules are most frequently expressed in undifferentiated tumor cells. Finally, as CSCs constantly interact with their microenvironment, protumorigenic alterations in the microenvironment (e.g., in stromal cells) will likely affect CSC properties and promote plasticity in CSC progeny [142,143].…”

Section: Intrinsic and Induced Plasticity In Csc Progenysupporting

confidence: 79%

“…Experimental EMT and inflammatory cytokines IL-6, IL-8, TGFβ, and TNFα can all promote the manifestation of CSC phenotypes and properties [130][131][132][133][134][135]. In fact, simply overexpressing certain oncogenic molecules (e.g., Nanog, CD44, Twist, hTERT, etc) is sufficient to reprogram primary non-tumorigenic cells or bulk cancer cells into stem-like cancer cells [136][137][138][139][140][141]. These latter observations [136][137][138][139][140][141] are consistent with the observations that such 'stemness' molecules are most frequently expressed in undifferentiated tumor cells.…”

Section: Intrinsic and Induced Plasticity In Csc Progenymentioning

confidence: 99%

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Understanding cancer stem cell heterogeneity and plasticity

2012

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Heterogeneity is an omnipresent feature of mammalian cells in vitro and in vivo. It has been recently realized that even mouse and human embryonic stem cells under the best culture conditions are heterogeneous containing pluripotent as well as partially committed cells. Somatic stem cells in adult organs are also heterogeneous, containing many subpopulations of self-renewing cells with distinct regenerative capacity. The differentiated progeny of adult stem cells also retain significant developmental plasticity that can be induced by a wide variety of experimental approaches. Like normal stem cells, recent data suggest that cancer stem cells (CSCs) similarly display significant phenotypic and functional heterogeneity, and that the CSC progeny can manifest diverse plasticity. Here, I discuss CSC heterogeneity and plasticity in the context of tumor development and progression, and by comparing with normal stem cell development. Appreciation of cancer cell plasticity entails a revision to the earlier concept that only the tumorigenic subset in the tumor needs to be targeted. By understanding the interrelationship between CSCs and their differentiated progeny, we can hope to develop better therapeutic regimens that can prevent the emergence of tumor cell variants that are able to found a new tumor and distant metastases.

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Section: Intrinsic and Induced Plasticity In Csc Progenysupporting

confidence: 79%

Section: Intrinsic and Induced Plasticity In Csc Progenymentioning

confidence: 99%

Understanding cancer stem cell heterogeneity and plasticity

2012

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“…IL-8 is often found upregulated in certain types of cancers and has been suspected to promote CSC's growth. Inhibition of IL-8 or SNAIL signaling appears to be beneficial for controlling colon and breast cancers [48]. Carcinopromoting role of M-CSF was confirmed, when disruption of M-CSF gene was found to cause diminished tumour growth and metastasis as a result of defective angiogenesis [49].…”

Section: Cytokines Regulate Cancer Stem Cells (Cscs)mentioning

confidence: 99%

Cytokine regulation of stem cells

Singh

Korkaya

2016

Preprint

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“…SB-T-1214, one of the new-generation taxoids which was developed as an attempt to improve widely used taxane-based anticancer agents [62], has been demonstrated to induce growth inhibition and apoptotic cell death in drug resistant [63,64] and tumorigenic CD133+/CD44+ colon cancer spheroids [65], suggesting that this compound can specifically target tumor-specific SCLCs by inhibiting some stemness-related signaling pathways.…”

Section: Influence Of Sclcs In the Therapeutic Settingmentioning

confidence: 99%

Cancer Cells with Stem Cell-Like Phenotypes and Liver Metastasis from Colon Carcinoma

Bellizzi¹,

Tommasi²

2013

J Liver

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Tumor heterogeneity contributes to the potentiality of tumors to invade and metastasize. Thus the identification of specific cells programmed to go to a specific site and establish themselves, actively proliferating and causing metastasis, could be fundamental for early diagnosis and for selective targeted therapy. Apart from gene signatures which seem to identify this tumor ability, selected cell populations with self-renewal potential have been recognized: stem cell-like cancer cells. In this paper we review recent evidence on the identification of colon cancer cells with stem cell-like properties which could have a key role in the liver metastasization. The potential clinical implication of their therapeutic eradication is also discussed. Keywords: Stem Cell-Like Cancer cells (SCLC); Colon cancer; MetastasisColorectal Cancer (CRC) is the third most common cancer in men (663,000 cases, 10.0% of the total) and the second in women (570,000 cases, 9.4% of the total) worldwide. Almost 60% of the cases occur in developed regions [1] and approximately 50% of patients develop synchronous or metachronous liver metastases within 2 years from the resection of the primary tumor [2]. Most colon cancer deaths result from the metastatic spread of tumor cells to the liver and other organs [3] and for this reason it is of great significance to identify new markers capable of discriminating earlier the potential that a primary tumor has to initiate a process of liver metastasization. The standard care in patients with operable liver-confined lesions is represented by a combination of chemotherapy and surgery [4]. However, there are still some critical issues to be solved. Firstly, surgical cures are relatively rare in this setting. Secondly, how to juxtapose chemotherapy and surgery, and the duration of chemotherapy. Finally, the possibility of pre-operative chemotherapy in the case of resectable metastases [5]. This is primarily due to the fact that current chemotherapy attacks the bulk of the cancer without affecting the chemo-resistant Stem Cell-Like Cancer cells (SCLCs). These can re-grow after treatment and, eventually, develop the changes responsible for the occurrence of drug-resistance [6][7][8] and facilitate a persistent and aggressive tumor phenotype, capable of invading other sites. In this scenario, understanding what drives metastasization to the liver and the characterization of clonal cells which selectively establish themselves in that site acquires great importance.In CRC, SCLCs are colon stem cells progenitors whose deregulated dynamics lead to the origin of a tumor [9]. At least two populations of progenitors are identified at the bottom of the normal colon Lieberkühn: true quiescent stem cells with high chemoresistance, and low proliferating potential [10]. They produce continuously the second compartment of stem cell progenitors with high mitogenic, differentiation and migratory potentials towards the top epithelium surface of the crypts. Upon migration upward through the crypt, these cells proli...

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SNAIL Regulates Interleukin-8 Expression, Stem Cell–Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells

Cited by 269 publications

References 52 publications

Understanding cancer stem cell heterogeneity and plasticity

Understanding cancer stem cell heterogeneity and plasticity

Cytokine regulation of stem cells

Cancer Cells with Stem Cell-Like Phenotypes and Liver Metastasis from Colon Carcinoma

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