Snails as indicators of pesticide drift, deposit, transfer and effects in the vineyard

Druart, Céline; Millet, Maurice; Scheifler, Renaud; Delhomme, Olivier; Raeppel, Caroline; Vaufleury, Annette de

doi:10.1016/j.scitotenv.2011.07.006

Cited by 48 publications

(30 citation statements)

References 49 publications

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“…Druart et al (2011) showed that exposure of snails to glyphosate at a dosage of 4 mg/kg body weight resulted in reduced growth rates. In another work, Dallegrave et al (2003) found that exposure of pregnant rats (between days 6 and 15 of gestation) to 500 mg/kg body weight of glyphosate reduced fetal growth rate.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

Jasper

Locatelli²,

Pilati³

et al. 2012

Interdisciplinary Toxicology

109

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We evaluated the toxicity of hepatic, hematological, and oxidative effects of glyphosate-Roundup® on male and female albino Swiss mice. The animals were treated orally with either 50 or 500 mg/kg body weight of the herbicide, on a daily basis for a period of 15 days. Distilled water was used as control treatment. Samples of blood and hepatic tissue were collected at the end of the treatment. Hepatotoxicity was monitored by quantitative analysis of the serum enzymes ALT, AST, and γ-GT and renal toxicity by urea and creatinine. We also investigated liver tissues histopathologically. Alterations of hematological parameters were monitored by RBC, WBC, hemoglobin, hematocrit, MCV, MCH, and MCHC. TBARS (thiobarbituric acid reactive substances) and NPSH (non-protein thiols) were analyzed in the liver to assess oxidative damage. Significant increases in the levels of hepatic enzymes (ALT, AST, and γ-GT) were observed for both herbicide treatments, but no considerable differences were found by histological analysis. The hematological parameters showed significant alterations (500 mg/kg body weight) with reductions of RBC, hematocrit, and hemoglobin, together with a significant increase of MCV, in both sexes of mice. In males, there was an important increase in lipid peroxidation at both dosage levels, together with an NPSH decrease in the hepatic tissue, whereas in females significant changes in these parameters were observed only at the higher dose rate. The results of this study indicate that glyphosate-Roundup® can promote hematological and hepatic alterations, even at subacute exposure, which could be related to the induction of reactive oxygen species.

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Section: Discussionmentioning

confidence: 99%

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

Jasper

Locatelli²,

Pilati³

et al. 2012

Interdisciplinary Toxicology

109

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“…Three commercial formulation of pesticides were selected: RU ® , Corail ® and BM because they are classically used in vineyard treatments [37] and data on their embryotoxicity (based on hatching success) were already available on C. aspersus [38,39].…”

Section: Chemicalsmentioning

confidence: 99%

“…Landsnails, especially C. aspersus species, which are living at the soil-plant-air interface, have already been used for ecotoxicological purposes at various life stages including early life stages [35][36][37][38][39]. Snail eggs offer particular interest to assess the impact of pesticides in soils, as their incubation takes place completely into this compartment.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity assessment of pesticides on terrestrial snail embryos by analysis of random amplified polymorphic DNA profiles

Baurand

Capelli

Vaufleury

2015

Journal of Hazardous Materials

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“…Such studies are characterized by several features, such as a high variation in the abundance of NTOs (in contrast to an analysis of species diversity) with, often, nonnormal distributions (Druart et al. ; Hoss et al. ; Oliveira‐Filho et al.…”

Section: Introductionmentioning

confidence: 99%

The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms

Semenov

Elsas

Glandorf

et al. 2013

Ecology and Evolution

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To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on varied experimental designs. The recent EFSA guidance document for environmental risk assessment (2010) does not provide clear and structured suggestions that address the statistics of field trials on effects on NTO's. This review examines existing practices in GM plant field testing such as the way of randomization, replication, and pseudoreplication. Emphasis is placed on the importance of design features used for the field trials in which effects on NTO's are assessed. The importance of statistical power and the positive and negative aspects of various statistical models are discussed. Equivalence and difference testing are compared, and the importance of checking the distribution of experimental data is stressed to decide on the selection of the proper statistical model. While for continuous data (e.g., pH and temperature) classical statistical approachesfor example, analysis of variance (ANOVA) -are appropriate, for discontinuous data (counts) only generalized linear models (GLM) are shown to be efficient. There is no golden rule as to which statistical test is the most appropriate for any experimental situation. In particular, in experiments in which block designs are used and covariates play a role GLMs should be used. Generic advice is offered that will help in both the setting up of field testing and the interpretation and data analysis of the data obtained in this testing. The combination of decision trees and a checklist for field trials, which are provided, will help in the interpretation of the statistical analyses of field trials and to assess whether such analyses were correctly applied.

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Snails as indicators of pesticide drift, deposit, transfer and effects in the vineyard

Cited by 48 publications

References 49 publications

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

Genotoxicity assessment of pesticides on terrestrial snail embryos by analysis of random amplified polymorphic DNA profiles

The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms

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