For cluster algebras from surfaces, there is a known formula for cluster variables and F -polynomials in terms of the perfect matchings of snake graphs. If the cluster algebra has trivial coefficients, there is also a known formula for cluster variables in terms of continued fractions. In this paper, we extend this result to cluster algebras with principal coefficients by producing a formula for the F -polynomials in terms of continued fractions.2000 Mathematics Subject Classification. Primary: 13F60, Secondary: 11A55 and 30B70.