Snake Venom as an Effective Tool Against Colorectal Cancer

Uzair, Bushra; Atlas, Nagina; Malik, Sidra Batool; Jamil, Nazia; Ojuolape, Salaam Temitope; Rehman, Mujaddad Ur; Khan, Barkat Ali

doi:10.2174/0929866525666180614112935

Cited by 13 publications

(9 citation statements)

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“…Disintegrins are capable of modulating the function of a broad range of integrins ( Gould et al, 1990 ; McLane et al, 2004 ), a family of heterodimeric receptors that play a fundamental role in mediating physiological and pathological processes, such as hemostasis and cancer ( Phillips et al, 1980 ; Hynes, 1987 ). Many aspects of the disintegrin protein family were reviewed recently: as tools for antitumor activity ( Schönthal et al, 2020 ), for antithrombotic agents ( Kuo et al, 2019 ), recombinant and chimeric proteins on research ( Huang et al, 2016 ; David et al, 2018 ; Uzair et al, 2018 ; Cesar et al, 2019 ; Lazarovici et al, 2019 ). This review focuses on structural studies of snake venom disintegrins and the features of integrin-disintegrin interaction.…”

Section: Introductionmentioning

confidence: 99%

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Vasconcelos

Estrada

David

et al. 2021

Front. Mol. Biosci.

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Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell and cell-matrix interaction that are widely studied as therapeutic targets. Snake venom disintegrins emerged from the snake venom metalloproteinase and are classified according to the sequence size and number of disulfide bonds. Evolutive structure and function diversification of disintegrin family involves a stepwise decrease in the polypeptide chain, loss of cysteine residues, and selectivity. Since the structure elucidation of echistatin, the description of the structural properties of disintegrins has allowed the investigation of the mechanisms involved in integrin-cell-extracellular matrix interaction. This review provides an analysis of the structures of all family groups enabling the description of an expanded classification of the disintegrin family in seven groups. Each group presents a particular disulfide pattern and sequence signatures, facilitating the identification of new disintegrins. The classification was based on the disintegrin-like domain of the human metalloproteinase (ADAM-10). We also present the sequence and structural signatures important for disintegrin-integrin interaction, unveiling the relationship between the structure and function of these proteins.

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Section: Introductionmentioning

confidence: 99%

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Vasconcelos

Estrada

David

et al. 2021

Front. Mol. Biosci.

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“…Peptides are an interesting component of the snake venom. Although otherwise poisonous, when used in the right proportions or structurally engineered, several venom peptides can be used directly as therapeutic drugs or as drug leads, Table 1 [ 22 , 23 , 24 , 25 , 26 ]. These peptides are of great value, due to their diversified and distinct pharmacological activity, and high affinity and selectivity towards their receptors.…”

Section: Introductionmentioning

confidence: 99%

Snake Venom Peptides: Tools of Biodiscovery

Munawar

Ali

Akrem

et al. 2018

Toxins

113

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Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive in their natural habitat. Venom is known to be a very poisonous mixture, consisting of a variety of molecules, such as carbohydrates, nucleosides, amino acids, lipids, proteins and peptides. Proteins and peptides are the major constituents of the dry weight of snake venoms and are of main interest for scientific investigations as well as for various pharmacological applications. Snake venoms contain enzymatic and non-enzymatic proteins and peptides, which are grouped into different families based on their structure and function. Members of a single family display significant similarities in their primary, secondary and tertiary structures, but in many cases have distinct pharmacological functions and different bioactivities. The functional specificity of peptides belonging to the same family can be attributed to subtle variations in their amino acid sequences. Currently, complementary tools and techniques are utilized to isolate and characterize the peptides, and study their potential applications as molecular probes, and possible templates for drug discovery and design investigations.

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“…In particular, known as “liquid gold” in the international market, and costing dozens of times more than gold, snake venom is insufficiently available as animal medicine in the international market. Due to its proven antivirus 7 , anti-inflammatory 8 , and immune regulatory 8 functions, snake venom not only has been in use as tranquilizer 9 , and for colorectal cancer treatment 10 , but also can be developed into health care products such as snake wines 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of intestinal bacteria among venom secretion and non-secrection snakes

Qin

Wang

Guo³

et al. 2019

Sci Rep

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To further investigate the bacterial community and identify the bacterial biomarkers between venom secretion and non-venom secretion snakes, 50 intestinal samples (25 large intestine, 25 small intestine) were obtained from 29 snakes (13 gut samples from Deinagkistrodon , 26 from Naja and 11 from Ptyas mucosa ). 16S rDNA high-throughput sequencing results showed that 29 bacterial phyla, 545 bacterial genera, and 1,725 OTUs (operational taxonomic units) were identified in these samples. OTU numbers and the Ace, Chao, Shannon, and Simpson indexes were very similar among the three breeds of snakes included in this study. The Bacteroidetes , Firmicutes , Fusobacteria and Proteobacteria were predominant bacterial phyla. The relative abundance at the phylum level among these samples was similar, and the difference between small and large intestinal samples was not obvious. However, at the genus level, venom secretion snakes Deinagkistrodon and Naja clustered together according to different breeds. 27, 24, and 16 genera were identified as core microbes for Deinagkistrodon , Naja , and Ptyas mucosa , respectively. Interestingly, the relative abundances of genera Hafnia_Obesumbacterium , Providencia , and Ureaplasma were found to be significantly higher in non-venom secretion snakes, and the genera Achromobacter , Cetobacterium , Clostridium innocuum group, Fusobacterium , Lachnoclostridium , Parabacteroides , and Romboutsia were only detected in venom secretion snakes. The function of these bacteria in venom secretion needs to be further studied, and these venom secretion related genera may be the promising target to improve venom production.

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Snake Venom as an Effective Tool Against Colorectal Cancer

Cited by 13 publications

References 0 publications

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Snake Venom Peptides: Tools of Biodiscovery

Comparative analysis of intestinal bacteria among venom secretion and non-secrection snakes

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