2023
DOI: 10.1002/jat.4544
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Snake venom toxins: Potential anticancer therapeutics

Benedict C. Offor,
Lizelle A. Piater

Abstract: Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment of these diseases. In this regard, Captopril used in the treatment of cardiovascular diseases was the first animal venom toxin‐based drug approved by the US Food and Dru… Show more

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Cited by 9 publications
(6 citation statements)
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References 148 publications
(227 reference statements)
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“…The anti-proliferative properties of venoms extracted from vertebrates and invertebrate species have been widely reported, where the potential application of venoms as anti-cancer agents has received considerable attention during the past decade, especially with snake venoms (for reviews, see [37][38][39][40]). Anticancer activity in various snake venoms has been reported for pancreatic tumor cells [41], human breast cancer (MCF-7), human hepatocellular carcinoma (HepG2) and human prostate carcinoma (DU145) cell lines [42], human leukemic cell lines (U937 and K562) and sarcoma in a Balb C mice model [43], colorectal and breast cancer cell lines [44], human prostate adenocarcinoma (LNCaP), human breast cancer (MCF-7), human colon adenocarcinoma (HT-29) and human osteoblastic osteosarcoma (Saos-2) cells [45], and human breast carcinoma cells (MDA-MB-231 and MCF-7) [46,47].…”
Section: Venoms As a Source Of Potential Anti-cancer Agentsmentioning
confidence: 99%
“…The anti-proliferative properties of venoms extracted from vertebrates and invertebrate species have been widely reported, where the potential application of venoms as anti-cancer agents has received considerable attention during the past decade, especially with snake venoms (for reviews, see [37][38][39][40]). Anticancer activity in various snake venoms has been reported for pancreatic tumor cells [41], human breast cancer (MCF-7), human hepatocellular carcinoma (HepG2) and human prostate carcinoma (DU145) cell lines [42], human leukemic cell lines (U937 and K562) and sarcoma in a Balb C mice model [43], colorectal and breast cancer cell lines [44], human prostate adenocarcinoma (LNCaP), human breast cancer (MCF-7), human colon adenocarcinoma (HT-29) and human osteoblastic osteosarcoma (Saos-2) cells [45], and human breast carcinoma cells (MDA-MB-231 and MCF-7) [46,47].…”
Section: Venoms As a Source Of Potential Anti-cancer Agentsmentioning
confidence: 99%
“…Snake venom is composed of a diverse combination of proteins and peptides, several of which have demonstrated promising medicinal possibilities [ 6 , 8 , 10 , 11 , 13 , 190 , 191 ]. The potential therapeutic applications of snake venom neurotoxins have been investigated owing to their capacity to selectively bind to certain receptors within the nervous system [ 192 ].…”
Section: Snake Venom Neurotoxins As Therapeuticsmentioning
confidence: 99%
“…One of the primary obstacles encountered in the development of snake venom neurotoxins as therapeutic agents lies in the attainment of adequate quantities suitable for clinical application [ 193 ]. The difficulties in acquiring adequate quantities of purified toxins from crude snake venom for scientific investigation and therapeutics can be mitigated by implementing venomics technologies, such as reverse-phase high-performance liquid chromatography (RP-HPLC) and followed by LC-MS/MS-based toxin identification [ 8 ]. Moreover, the future of advancements and discoveries lies in the use of efficient biotechnologies, such as cloning and large-scale toxin expression systems, and the optimization of drug delivery by toxin conjugation to monoclonal antibodies and nanoparticles [ 6 , 12 ].…”
Section: Snake Venom Neurotoxins As Therapeuticsmentioning
confidence: 99%
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