Snake venom toxins targeting the central nervous system

Talukdar, Amit; Maddhesiya, Priya; Namsa, Nima D.; Doley, Robin

doi:10.1080/15569543.2022.2084418

Cited by 4 publications

(3 citation statements)

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“…There is a vast and growing canon of animal and plant venom peptide toxins used as pharmacological tools and as potential therapeutics targeting ion channels (for reviews see: Cardoso, 2020 ; Dueñas-Cuellar et al, 2020 ; Groome, 2023 ; Luo et al, 2022 ; Mendes et al, 2023 ; Nogueira Souza et al, 2023 ; Osipov and Utkin, 2023 ; Talukdar et al, 2023 ; Wulff et al, 2019 ). Soricin, one such toxin from the Northern short-tailed shrew ( Blarina brevicauda ), shortened to the C-terminal 13mer peptide (SOR-C13), was shown to be a potent TRPV6 blocker (IC 50 = 14 nM).…”

Section: Clinical Research Example 2—trpv6 In Calcium Homeostasis Gen...mentioning

confidence: 99%

News and views on ion channels in cancer: is cancer a channelopathy?

Bell,

Leanza,

Gentile

et al. 2023

Front. Pharmacol.

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Ion channels are key signaling proteins found throughout the body; they are critical in many, wide-ranging physiological processes, from gene expression, sensory perception and processing to the cardiac action potential. When ion channel activity goes awry, for example, via mutation, damage or disrupted homeostasis, the outcome can result in causation, development and/or maintenance of disease. Ion channel dependent diseases have been dubbed channelopathies. Recent studies on the role of ion channels in cancer biology suggest that cancer is one such channelopathy. Many ion channels have now been implicated in the cellular processes that are affected in a multitude of cancers. In the last two decades, the field of ion channel and cancer research has been growing exponentially: a combination of developments in molecular biology, genetics, electrophysiology and automation have driven an explosion in our capabilities to interrogate ion channel pathways; how, why and where they go wrong and therapeutic interventions to correct their pathophysiology in cancer. A review of this vast and rapidly developing field would require a titanic tome to merely dimple the surface of research that has ballooned recently. In lieu of that huge undertaking—for the benefit of both authors and readers - this review discusses select examples of primary, applied and clinical research, aiming to shine a light on some of the more innovative and novel findings that this exciting field is excavating.

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Section: Clinical Research Example 2—trpv6 In Calcium Homeostasis Gen...mentioning

confidence: 99%

News and views on ion channels in cancer: is cancer a channelopathy?

Bell,

Leanza,

Gentile

et al. 2023

Front. Pharmacol.

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“…Beyond these properties, some snake venom compounds have already been approved for treating high blood pressure (Captopril) and as antiplatelet (Tirofiban and Eptifibatide) . In the central nervous system, snake venom compounds are known to interact with distinct receptors, reducing pain, neuroinflammation, anxiety, and depression …”

Section: Introductionmentioning

confidence: 99%

A Snake Venom Peptide and Its Derivatives Prevent Aβ₄₂ Aggregation and Eliminate Toxic Aβ₄₂ Aggregates In Vitro

Camargo,

Gering,

Mastalipour

et al. 2024

ACS Chem. Neurosci.

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Over a century has passed since Alois Alzheimer first described Alzheimer's disease (AD), and since then, researchers have made significant strides in understanding its pathology. One key feature of AD is the presence of amyloid-β (Aβ) peptides, which form amyloid plaques, and therefore, it is a primary target for treatment studies. Naturally occurring peptides have garnered attention for their potential pharmacological benefits, particularly in the central nervous system. In this study, nine peptide derivatives of Crotamine, a polypeptide from Crotalus durissus terrificus Rattlesnake venom, as well as one D-enantiomer, were evaluated for their ability to modulate Aβ 42 aggregation through various assays such as ThT, QIAD, SPR, and sFIDA. All tested peptides were able to decrease Aβ 42 aggregation and eliminate Aβ 42 aggregates. Additionally, all of the peptides showed an affinity for Aβ 42 . This study is the first to describe the potential of crotamine derivative peptides against Aβ 42 aggregation and to identify a promising D-peptide that could be used as an effective pharmacological tool against AD in the future.

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“…Snake and scorpion venoms contain toxins that impact the prey's circulatory, nerve, muscular, and a variety of other systems [1]. The voltage-gated sodium (Navs) and potassium channels (Kvs) are known targets of scorpion venom peptide toxins, and several of these toxins have antimicrobial action [2]. For example, compounds with anticoagulant and antiviral properties were identified in scorpion venoms or synthesized from venom gland cDNA libraries.…”

Section: Introductionmentioning

confidence: 99%

Molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds

Alshammari¹

2022

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Snake venom toxins targeting the central nervous system

Cited by 4 publications

References 246 publications

News and views on ion channels in cancer: is cancer a channelopathy?

News and views on ion channels in cancer: is cancer a channelopathy?

A Snake Venom Peptide and Its Derivatives Prevent Aβ₄₂ Aggregation and Eliminate Toxic Aβ₄₂ Aggregates In Vitro

Molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds

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Snake venom toxins targeting the central nervous system

Cited by 4 publications

References 246 publications

News and views on ion channels in cancer: is cancer a channelopathy?

News and views on ion channels in cancer: is cancer a channelopathy?

A Snake Venom Peptide and Its Derivatives Prevent Aβ42 Aggregation and Eliminate Toxic Aβ42 Aggregates In Vitro

Molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds

Contact Info

Product

Resources

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A Snake Venom Peptide and Its Derivatives Prevent Aβ₄₂ Aggregation and Eliminate Toxic Aβ₄₂ Aggregates In Vitro