Snakebite-associated thrombotic microangiopathy: a spotlight on pharmaceutical interventions

Noutsos, Tina

doi:10.1080/17512433.2023.2220963

Expert Review of Clinical Pharmacology

2023

DOI: 10.1080/17512433.2023.2220963

|View full text |Cite

Snakebite-associated thrombotic microangiopathy: a spotlight on pharmaceutical interventions

Tina Noutsos

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Thrombotic microangiopathy following snake envenomation in pregnancy

Mazumder,

Selvam,

Karthikashri

et al. 2024

QJM: An International Journal of Medicine

View full text Add to dashboard Cite

Thrombotic microangiopathy following snake envenomation in pregnancy

Mazumder,

Selvam,

Karthikashri

et al. 2024

QJM: An International Journal of Medicine

View full text Add to dashboard Cite

Haemotoxicity of snakes: a review of pathogenesis, clinical manifestations, novel diagnostics and challenges in management

Alvitigala,

Dissanayake,

Weeratunga

et al. 2025

Transactions of the Royal Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Haemotoxicity is the most common complication of systemic envenoming following snakebite, leading to diverse clinical syndromes ranging from haemorrhagic to prothrombotic manifestations. Key haematological abnormalities include platelet dysfunction, venom-induced consumption coagulopathy, anticoagulant coagulopathy and organ-threatening thrombotic microangiopathy. Diagnostic methods include the bedside whole blood clotting test, laboratory coagulation screening and other advanced methods such as thromboelastogram and clot strength analysis. The primary management strategies are venom neutralisation with antivenom and correction of coagulopathy with blood component transfusions, while options such as plasma exchange are utilised in certain cases. Recent advancements in understanding the pathogenesis of haemotoxicity have facilitated the development of new diagnostic and treatment modalities. This review summarises current knowledge on the pathogenesis, diagnosis, clinical and laboratory manifestations and treatment of the haematological effects of snake envenoming. Furthermore, it highlights important challenges concerning diagnosis and management. Addressing these challenges is crucial for achieving the WHO's goal of reducing deaths and disabilities caused by snakebites by 2030.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Snakebite-associated thrombotic microangiopathy: a spotlight on pharmaceutical interventions

Cited by 2 publications

References 101 publications

Thrombotic microangiopathy following snake envenomation in pregnancy

Thrombotic microangiopathy following snake envenomation in pregnancy

Haemotoxicity of snakes: a review of pathogenesis, clinical manifestations, novel diagnostics and challenges in management

Contact Info

Product

Resources

About