Snakebite envenomation turns again into a neglected tropical disease!

Chippaux, Jean-Philippe

doi:10.1186/s40409-017-0127-6

Cited by 419 publications

(353 citation statements)

References 9 publications

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“…our study provides a much-needed historical framework for this system that has practical implications. Snakebite envenomation is recognized by the World Health Organization as a priority neglected tropical disease, and terciopelo pitvipers are model organisms in toxinology (Chippaux, 2017;Gutiérrez, 2009). In this sense, our findings of multiple recently evolved and previously unrecognized lineages could help…”

Section: Neotropical Diversification Implications and Future Directmentioning

confidence: 81%

“…Finally, since terciopelo snakes are the leading cause of snakebite accidents across their distribution (Otero‐Patiño, ; Warrell, ), our study provides a much‐needed historical framework for this system that has practical implications. Snakebite envenomation is recognized by the World Health Organization as a priority neglected tropical disease, and terciopelo pitvipers are model organisms in toxinology (Chippaux, ; Gutiérrez, ). In this sense, our findings of multiple recently evolved and previously unrecognized lineages could help (a) inform future comparative toxinological studies, (b) establish a better understanding of the appropriate selection and mixture of venoms for immunization in order to produce more effective antivenoms, and (c) better understand the role of geographic variation in venom in complex clinical manifestations of snakebite accidents produced by these organisms in humans and livestock.…”

Section: Discussionmentioning

confidence: 99%

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Divergence of tropical pitvipers promoted by independent colonization events of dry montane Andean habitats

Salazar-Valenzuela

Kuch

Torres‐Carvajal

et al. 2019

Journal of Biogeography

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Aim A poorly explored feature of the origin and maintenance of Neotropical biodiversity is how the evolutionary dynamics of colonization and differentiation in relation to lowland and highland habitats has impacted lineage formation. Most speciation models for this region have focused on vicariant events, whereas the need to assess the influence of demographic processes has been recognized only recently. We evaluate if the origin of Andean montane lineages of terciopelo pitvipers is explained by either of two historical processes that represent distinct phylogeographic mechanisms: differentiation by isolation within the highlands or different dispersal events from the lowlands. Location Western Ecuador. Taxon Terciopelo pitvipers (Bothrops asper species complex). Methods We use genomic data and genetic clustering analyses, evaluation of historical migration between genetic clusters and demographic model selection to investigate recent diversification events in South America using a vertebrate group rarely explored in phylogeographic studies: tropical Andean snakes. Specifically, the origin of two Ecuadorian montane lineages of terciopelo pitvipers was evaluated given ambiguous phylogenetic relationships with the presumably ancestral Pacific lowland lineage. Results Discrepancies of evolutionary relationships previously obtained with tree‐like methods are resolved through the use of modelling approaches. We found strong support for the independent origin of montane lineages based on topologies inferred by maximum‐likelihood trees and modelling approaches that take into account possible gene flow. This suggests dispersal rather than in‐situ differentiation as the most likely mechanism by which the montane linages originated. Main conclusions Recent large‐scale studies have found support for identifying dispersal events as important drivers of diversification in the Neotropical region. We contribute to these ideas by identifying a fine‐scale case in a rarely studied group of animals ‐Andean snakes‐ in which river valleys acted as an entrance for the upward colonization of montane dry habitats and subsequent ecological diversification.

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Section: Neotropical Diversification Implications and Future Directmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Divergence of tropical pitvipers promoted by independent colonization events of dry montane Andean habitats

Salazar-Valenzuela

Kuch

Torres‐Carvajal

et al. 2019

Journal of Biogeography

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“…The most accidents with snakes were registered in the tropics mainly of farmers by contact during the field work. In consequence, snake envenomation was resumed during 2017 to the list of neglected tropical diseases [5].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive snake venomics of the Okinawa Habu pit viper, Protobothrops flavoviridis, by complementary mass spectrometry-guided approaches

Damm

Hempel

Nalbantsoy

2018

Preprint

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Abstract:The Asian world is home to a multitude of venomous and dangerous snakes, which are attributed to various medical effects used in the preparation of traditional snake tinctures and alcoholics, like the Japanese snake wine, named Habushu. The aim of this work was to perform the first quantitative proteomic analysis of the Protobothrops flavoviridis pit viper venom. Accordingly, the venom was analyzed by complimentary bottom-up and top-down mass spectrometry techniques. The mass spectrometry-based snake venomics approach revealed that more than half of the venom is composed of different phospholipases A2 (PLA2). The combination with an intact mass profiling led to the identification of the three main Habu PLA2s. Furthermore, nearly one-third of the total venom consists of snake venom metalloproteinases and disintegrins, and several minor represented toxins families were detected: CTL, CRISP, svSP, LAAO, PDE and 5'-nucleotidase. Finally, the venom of P. flavoviridis contains certain bradykinin-potentiating peptides and related peptides, like the svMP inhibitors pEKW, pEQW, pEEW and pENW. In preliminary MTT cytotoxicity assays the highest cancerous-cytotoxicity of the crude venom was measured against human neuroblastoma SH-SY5Y cells and shows in some fractions disintegrin-like effects.

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“…Snakebite envenoming is estimated to cause 95 000‐125 000 deaths and up to 400 000 permanent injuries or disabilities worldwide on an annual basis. This serious health threat has been recognized by the World Health Organization, and snakebite envenoming is classified as a category A neglected tropical disease . In May of 2018, the World Health Assembly adopted a resolution on snakebite envenoming, thereby providing a mandate to develop a comprehensive plan to effectively control the burden of envenoming and reduce its debilitating impact.…”

mentioning

confidence: 99%

“…This serious health threat has been recognized by the World Health Organization, and snakebite envenoming is classified as a category A neglected tropical disease. 1 In May of 2018, the World Health Assembly adopted a resolution on snakebite envenoming, 2 thereby providing a mandate to develop a comprehensive plan to effectively control the burden of envenoming and reduce its debilitating impact. The multisectoral strategy that is required to achieve this will address socioeconomic, environmental, and healthcare challenges.…”

mentioning

confidence: 99%