SNAP‐25 in hippocampal CA1 region is involved in memory consolidation

Hou, Qiuling; Gao, Xiang; Zhang, Xuehan; Kong, Lingbao; Wang, Xinming; Bian, Wei; Tu, Yanyang; Jin, Meilei; Zhao, Guoping; Li, Baoming; Jing, Naihe; Yu, Lei

doi:10.1111/j.1460-9568.2004.03600.x

Cited by 68 publications

(42 citation statements)

References 53 publications

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“…In Alzheimer's disease and other dementia-related disorders, there is a significant decrease of synaptophysin expression in the presynaptic vesicles due, in part, to synapse loss. As hypothesized, loss of immunoactivity for the presynaptic vesicle marker proteins SNAP-25 may contribute to the progression of memory decline in patients with Alzheimer's disease [36,37].…”

Section: Discussionmentioning

confidence: 98%

Early-Life Lead Exposure Affects the Activity of TNF-α and Expression of SNARE Complex in Hippocampus of Mouse Pups

Wang

et al. 2009

Biol Trace Elem Res

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This study aims to investigate the effects of maternal lead exposure on learning and memory ability and the protein expression of TNF-alpha and SNARE complex (SNAP-25, VAMP-2, and Syntaxin 1A) in hippocampus of mice offspring. Pb exposure was initiated from beginning of gestation to weaning. Pb acetate administered in drinking solutions was dissolved in distilled deionized water at 0.1%, 0.5%, and 1% groups, respectively. On the PND21, the learning and memory ability of mouse pups was tested by water maze test, and the Pb levels in their blood and hippocampus were also determined. The protein expression of TNF-alpha and SNARE complex in hippocampus was measured by immunohistochemistry and Western blotting. The Pb levels in blood and hippocampus of all exposure groups were significantly higher than control group (P < 0.05). In the water maze test, the performances of 0.5% and 1% groups were worse than that of control group (P < 0.05). The expression of TNF-alpha, Syntaxin 1A, and VAMP-2 was increased in Pb-exposed groups comparing control group (P < 0.05), but the expression of SNAP-25 was decreased (P < 0.05). Up-regulation of TNF-alpha and disturbance of SNARE expression in the hippocampus of pups may contribute to impairment of learning and memory ability associated with maternal Pb exposure.

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Section: Discussionmentioning

confidence: 98%

Early-Life Lead Exposure Affects the Activity of TNF-α and Expression of SNARE Complex in Hippocampus of Mouse Pups

Wang

et al. 2009

Biol Trace Elem Res

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“…Total RNA (10 g) from P19 cells during neural differentiation was analyzed by Northern blot as described previously (32). Reverse transcription was performed with 5 g of total RNA using SuperScript II reverse transcriptase (Invitrogen).…”

Section: Methodsmentioning

confidence: 99%

Different Transcription Factors Regulate nestin Gene Expression during P19 Cell Neural Differentiation and Central Nervous System Development

Jin

Liu

Bian

et al. 2009

Journal of Biological Chemistry

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Nestin is a molecular marker for neural progenitor cells. Rat and human nestin genes possess a central nervous system-specific enhancer within their second introns. However, the transcription factors that bind to the nestin enhancer have not been fully elucidated. Here, we show that the second intron of the mouse nestin gene is sufficient to drive reporter gene expression in the developing nervous system. The core sequence of this central nervous system-specific enhancer localizes to the 3 320-bp region. The cis-elements for Sox and POU family transcription factors and the hormone-responsive element are essential for nestin expression during embryonic carcinoma P19 cell neural differentiation and in the developing chick neural tube. Interestingly, different transcription factors bind to the nestin enhancer at different stages of P19 cell neural differentiation and central nervous system development. Sox2 and SF1 may mediate basal nestin expression in undifferentiated P19EC cells, whereas Sox2, Brn1, and Brn2 bind to the enhancer in P19 neural progenitor cells. Similarly, in vivo, Oct1 binds to the nestin enhancer in embryonic day 8.5 (E8.5) mouse embryos, and Oct1, Brn1, and Brn2 bind to this enhancer in E10.5 and E12.5 mouse embryos. Our studies therefore suggest a temporal coordination of transcription factors in determining nestin gene expression.

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“…Furthermore, this protein participates in the consolidation of conditioned fear memory as a member of the syntaxin super-family (Fujiwara et al 2006). Previous studies have also suggested that SNAP-25 is involved in cognitive dysfunction, verbal memory and memory consolidation (Spellmann et al 2008;Golimbet et al 2010;Hou et al 2004). Moreover, STX1 interacts with SNAP-25 protein, which plays an essential role in the regulation of neurotransmitter release (Lin and Scheller 2000).…”

Section: Discussionmentioning

confidence: 90%

Differential protein expression analysis following olfactory learning in Apis cerana

et al. 2015

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Studies of olfactory learning in honeybees have helped to elucidate the neurobiological basis of learning and memory. In this study, protein expression changes following olfactory learning in Apis cerana were investigated using isobaric tags for relative and absolute quantification (iTRAQ) technology. A total of 2406 proteins were identified from the trained and untrained groups. Among these proteins, 147 were differentially expressed, with 87 up-regulated and 60 down-regulated in the trained group compared with the untrained group. These results suggest that the differentially expressed proteins may be involved in the regulation of olfactory learning and memory in A. cerana. The iTRAQ data can provide information on the global protein expression patterns associated with olfactory learning, which will facilitate our understanding of the molecular mechanisms of learning and memory of honeybees.

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SNAP‐25 in hippocampal CA1 region is involved in memory consolidation

Cited by 68 publications

References 53 publications

Early-Life Lead Exposure Affects the Activity of TNF-α and Expression of SNARE Complex in Hippocampus of Mouse Pups

Early-Life Lead Exposure Affects the Activity of TNF-α and Expression of SNARE Complex in Hippocampus of Mouse Pups

Different Transcription Factors Regulate nestin Gene Expression during P19 Cell Neural Differentiation and Central Nervous System Development

Differential protein expression analysis following olfactory learning in Apis cerana

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