Snapshot of phase transition in thermoresponsive hydrogel PNIPAM: Role in drug delivery and tissue engineering

Ashraf, Sajjad; Park, Hun-Kuk; Park, Hansoo; Lee, Soo−Hong

doi:10.1007/s13233-016-4052-2

Cited by 175 publications

(87 citation statements)

References 69 publications

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“…A large number of hydrogen bonds may be formed between γ-PGA and H 2 O, which affects the temperature change of gel formation. 36,37 To quantitatively characterize the thermosensitivity of the prepared hydrogel, we conducted rheological tests with different ratios sample to measure the changes of its storage modulus (G′) and loss modulus (G″) with temperature. As shown in Figure 3C and Fig S2, at lower temperatures, G′ was larger than G″, indicating a liquid-like sol state, whereas with the heating process, G″ increased significantly faster than G′, indicating a solid-like gel state.…”

Section: Gelation Property Of Polymers With Different Formulationmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Methods: The purpose of this research was to prepare a novel thermo-sensitive hydrogelpoly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) to improve the effect for trauma treatment. The micromorphology of the hydrogel was observed by scanning electron microscope and the physical properties were measured. The biocompatibility of hydrogel was evaluated by MTT experiment, and the effect of hydrogel on skin wound healing was evaluated by in vivo histological staining. Results: Gelling behavior and differential scanning calorimeter outcomes showed that the PP hydrogels possessed thermo-sensitivity at physiological temperature and the phase transformation temperature was 28.2°C. The high swelling rate and good water retention were conducive to wound healing. The activity of SOD in vitro was up to 85% at 10 h, which was advantageous to eliminate the superoxide anion. MTT assay revealed that this hydrogel possessed good biocompatibility. Dressings of PP loaded with SOD (SOD-PP) had a higher wound closure rate than other treatments in vivo in diabetic rat model. Discussion: The SOD-PP thermo-sensitive hydrogels can effectively promote wound healing and have good application prospects for wound repair.

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Section: Gelation Property Of Polymers With Different Formulationmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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“…Poly( N -isopropylacrylamide) (PNIPAM) has been widely investigated as a triggered drug release vehicle [27]. As a thermoresponsive polymer, PNIPAM undergoes a reversible, entropically driven phase transition at a lower critical solution temperature (LCST), resulting in the expulsion of water and a subsequent change in polymer volume.…”

Section: Introductionmentioning

confidence: 99%

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

Hathaway

Ajuebor

Stephens

et al. 2017

Journal of Controlled Release

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Staphylococcus aureus infections of the skin and soft tissue pose a major concern to public health, largely owing to the steadily increasing prevalence of drug resistant isolates. As an alternative mode of treatment both bacteriophage endolysins and bacteriocins have been shown to possess antimicrobial efficacy against multiple species of bacteria including otherwise drug resistant strains. Despite this, the administration and exposure of such antimicrobials should be restricted until required in order to discourage the continued evolution of bacterial resistance, whilst maintaining the activity and stability of such proteinaceous structures. Utilising the increase in skin temperature during infection, the truncated bacteriophage endolysin CHAPK and the staphylococcal bacteriocin lysostaphin have been co-administered in a thermally triggered manner from Poly(N-isopropylacrylamide) (PNIPAM) nanoparticles. The thermoresponsive nature of the PNIPAM polymer has been employed in order to achieve the controlled expulsion of a synergistic enzybiotic cocktail consisting of CHAPK and lysostaphin. The point at which this occurs is modifiable, in this case corresponding to the threshold temperature associated with an infected wound. Consequently, bacterial lysis was observed at 37 °C, whilst growth was maintained at the uninfected skin temperature of 32 °C.

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“…The thermosensitive polymer phase transition is conditioned by: polymer intermolecular interaction, temperature, the presence of functional polymer groups, ionic and hydrophobic interaction and hydrogen bonds [102].…”

Section: (1) (2018) 79-91mentioning

confidence: 99%

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

Urošević¹,

Nikolić²,

Ilić‐Stojanović³

et al. 2018

Adv Techol

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Hydrogels are three-dimensional polymer networks which have the capacity to retain a large quantity of water or biological fluids in the swollen state. Thermosensitive hydrogels have received special attention of reserachers since they represent a parameter which frequently changes in chemical, biological and physiological systems. Thermosensitive hydrogels have the critical solution temperature, i.e. they exhibit a substantial change in volume with the temperature change. Homopolymers poly(N-isopropylmethacrylamide) (poly(NIPMAM)) and poly(N-isopropylacrylamide) (poly(NIPAM)) are thermosensitive materials which have lately become the subject of intensive study. Monomer N-isopropylmethacrylamide, NIPMAM, enters into copolymerization with monomer N-isopropylacrylamide, NIPAM, in order to create a system with a phase transition temperature approximate to the human body temperature. In literature data there is available information on the synthesis and characterization of microgels, nanogels and copolymers based on NIPMAM and NIPAM. These thermosensitive polymer materials are used in controlled drug delivery and protein immobilization.

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Snapshot of phase transition in thermoresponsive hydrogel PNIPAM: Role in drug delivery and tissue engineering

Cited by 175 publications

References 69 publications

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

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