SnapshotDx Quiz: December 2020

Abstract

Among gd and ab T cells, only the latter are found in human epidermis. b. Histopathology reliably distinguishes ACD from irritant contact dermatitis and atopic dermatitis. c. Exposure of the skin to contact allergen induces the accumulation of allergen-specific CD8þCD69þCD103þ T cells in the skin. d. In humans, Vd1 T cells (the major subset of gd T cells) possess dendritic shape as in rodents. e. CD4þCCR10þ memory T cells disappear from the dermis after the clinical resolution of ACD. 3. Which of the following answers is FALSE according to the article by Gadsbøll et al. (2020) a. Exposure to allergens leads to the generation of CD8þ epidermal resident memory T (T RM) cells (skin T RM cells). b. Dendritic epidermal T cells (DETCs) are not required for the generation of CD8þ epidermal T RM cells after exposing the skin to an allergen. c. Expansion of the CD8þ epidermal T RM cell population after allergen re-exposure is mediated solely by local proliferation in the epidermis and not by recruitment from the circulation. d. CD8þ epidermal T RM cells have a higher respiratory capacity than DETCs. e. The magnitude of the cutaneous hypersensitivity reaction and the frequency of CD8þ epidermal T RM cells directly correlate with the dose of the allergen.