Asymmetric Fano resonance arise from quantum interference between discrete and continuum state. The characteristic asymmetry has attracted strong interests in understanding light-induced optoelectronic responses and corresponding applications. In conventional solids, however, the tunability of Fano resonance is generally limited by material's intrinsic * E-mail: hychoi@yonsei.ac.kr 2 property. Topological insulators are unique states of matters embodying both conducting Dirac surface and underlying bulk. If it is possible to manipulate the two coexisting states, then it should form an ideal laboratory for realizing a tunable topological Fano system. Here, with recently discovered topological phase transition in (Bi 1-x In x ) 2 Se 3 , we report new tunable Fano interference phenomena. By engineering the spatial overlap between surface Dirac electrons (continuous terahertz transitions) and bulk phonon (discrete mode at ~ 2 terahertz), we continuously tune, abruptly switch, and dynamically modulate the Fano resonance.Eliminating the topological surface via decreasing spin-orbit coupling-that is, across topological and non-topological phase, we find that the asymmetric Fano spectra return to the symmetric profile. Laser-excited ultrafast terahertz spectroscopy reveals that the controlled spatial overlap is responsible for the picosecond tunability of the Fano resonance, suggesting potentials toward optically controllable topological Fano systems.3