Sneddon's syndrome with negative antiphospholipid antibodies.

Martínez-Menéndez, B; Pérez-Sempere, A; Gonzalez-Rubio, M; Villaverde-Amundarain, F J; Bermejo-Pareja, F

doi:10.1161/str.21.10.1510b

Cited by 10 publications

(3 citation statements)

References 20 publications

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“…Ten of our 46 patients 22%), or 17 patients (37%) if modem criteria of aCL positivity are used, and some patients with Sneddon's syndrome presented in the litera ture [32][33][34][35] had no aCL and LA. The pathogenesis of Sneddon's syndrome in these cases needs to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Sneddon's Syndrome and the Primary Antiphospholipid Syndrome

Калашникова¹,

Nasonov²,

Stoyanovich³

et al. 1994

Cerebrovasc Dis

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Forty-six patients (33 women, 13 men, mean age 40 years) with Sneddon''s syndrome characterized by an ischemic cerebrovascular disease combined with widespread livedo were studied. The clinical picture also included fetal loss (20 of 29 women who had become pregnant), peripheral venous thrombosis (12 patients), ischemic heart disease (18 patients), thrombocytopenia (8 of 40 patients), arterial hypertension (27 patients), headache (38 patients), and epileptic seizures (5 patients), and was similar to that of the antiphospholipid syndrome (APS). In 36 of 46 (78%) patients antiphospholipid antibodies (aPL) were found: anticardiolipin antibodies >5 GPL in 23 of 46 (50%) and lupus anticoagulant in 26 of 43 (61 %) patients. The presence of clinical and immunological manifestations of the APS in 78% of patients in the absence of typical systemic lupus erythematosus features allows one to consider these Sneddon''s syndrome cases as examples of primary APS. The pathogenesis of Sneddon''s syndrome in aPL-negative patients needs to be clarified.

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Section: Discussionmentioning

confidence: 99%

Sneddon's Syndrome and the Primary Antiphospholipid Syndrome

Калашникова¹,

Nasonov²,

Stoyanovich³

et al. 1994

Cerebrovasc Dis

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“…3,8,14,16,17,32,33 Recently, characteristic histopathological findings have been reported from skin biopsies of patients with SS.34 These consisted of inflammatory changes in the endothelium (endothelitis) of small arteries and were followed by subendothelial cell proliferation leading to partial or complete occlusion. Although these findings are characteristic, skin biopsy cannot confirm SS unless cerebral involvement is documented.…”

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confidence: 99%

Sneddon's syndrome: diagnosis by skin biopsy and MRI in 17 patients.

Stockhammer

Felber

Zelger

et al. 1993

Stroke

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“…We identified 97 case series and reports with 426 individuals with Sneddon's syndrome. In 42 case reports and 23 case series, containing a total of 208 individuals, the presence or absence of headache is not mentioned (15–64). The female to male ratio for this group is 3 : 1.…”

Section: Resultsmentioning

confidence: 99%

Sneddon's Syndrome

et al. 2006

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Sneddon's syndrome refers to the enigmatic association of ischaemic stroke and livedo reticularis. We review the Sneddon's syndrome literature examining the association of this condition with headache, including migraine. Case reports and series are stratified into two groups based on headache reference. In the group without a reference to headache, there are 208 persons, with a female to male ratio of 3 : 1. In the headache reference group, there are 175 persons, with a female to male ratio of 3.5 : 1. The proportion with headache in this second group is 58% (102 individuals), with headache described as migraine in 28 (27.5%) of the headache subjects, including six with migraine with aura. The frequency of headache is not significantly higher in persons with positive anti-phospholipid antibodies compared with the negative cohort (43% vs. 32%, P = 0.07). A review of the histopathological, radiological and serological data in Sneddon's syndrome and migraine underscores the plausibility of an association. Considered in the context of increased risk of stroke with migraine, a higher frequency of livedo in migraineurs with stroke, and the association of migraine and livedo reticularis, the question of whether livedo reticularis may be a risk marker for stroke in migraineurs is an area for further study.

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Sneddon's syndrome with negative antiphospholipid antibodies.

Cited by 10 publications

References 20 publications

Sneddon's Syndrome and the Primary Antiphospholipid Syndrome

Sneddon's Syndrome and the Primary Antiphospholipid Syndrome

Sneddon's syndrome: diagnosis by skin biopsy and MRI in 17 patients.

Sneddon's Syndrome

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