2015
DOI: 10.1080/21624054.2014.1003002
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SNF-10 connects male-derived signals to the onset of sperm motility inC. elegans

Abstract: Sperm from the nematode C. elegans gain motility during a process termed activation, which they initiate in response to specific environmental signals. During this process, a number of subcellular rearrangements occur, culminating in an altered morphology that allows the cell to crawl toward and fertilize oocytes. Both hermaphrodites and males produce sperm, and redundant, sex-biased pathways regulate the sperm's activation. The male-derived signal for sperm activation involves TRY-5, a trypsin-like serine pro… Show more

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Cited by 2 publications
(10 citation statements)
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“…Recognition of this relationship arose from noting regulation of Tg O/GABA-AT by MORC 62 combined with culture and sequencing of Frenkel Live Vaccine strain T-263 and analysis of T-263 mutations 43 , 44 , 45 , 46 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 which occurred in genes responsible for capacitation and conception ( Tables 2 , 3 , and 4 , and in color Tables S4–S6 ; Figures 8 , 9 , 10 , 11 , and 12 ). 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , ...…”
Section: Resultsmentioning
confidence: 99%
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“…Recognition of this relationship arose from noting regulation of Tg O/GABA-AT by MORC 62 combined with culture and sequencing of Frenkel Live Vaccine strain T-263 and analysis of T-263 mutations 43 , 44 , 45 , 46 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 which occurred in genes responsible for capacitation and conception ( Tables 2 , 3 , and 4 , and in color Tables S4–S6 ; Figures 8 , 9 , 10 , 11 , and 12 ). 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , ...…”
Section: Resultsmentioning
confidence: 99%
“…Change in bicarbonate, pH, ionicity triggers development process. (∗GABA modulates all steps of capacitation) 45 , 73 , 74 , 75 , 84 AlphaFold2 predicts mutation could affect function TGME49_209985 -PKA + (cAMP-dependent protein kinase A) (Noted because mutation annotated as a single copy in ToxoDB- not certain mutated) (Rhoptry +other?) Cell signaling, capacitation, adenyl cyclase, male and female gamete, motility, cell volume, osmolality.…”
Section: Resultsmentioning
confidence: 99%
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“…For example, in the ES stage, putative proteolysis regulators (serine proteases 47 precursor and serine protease inhibitor 3/4) and heat shock proteins (HSPs) were highly expressed. These genes could cleave inactive molecules into their active forms (Fenker and Stanfield, 2015), participate in oogenesis (Ambrosio and Schedl, 1984;Neuer et al, 2000) and ovulation (LaFlamme et al, 2012), and enhance oogenesis (Pilpel et al, 2008) in a number of species. Therefore, these results could predict that the high expression levels of these genes in the ES stage might be relate to the oogenesis of A. bambawalei.…”
Section: Discussionmentioning
confidence: 99%