Sniping Cancer Stem Cells with Nanomaterials

Wang, Wen-Da; Guo, Yan-Yu; Yang, Zhong-Lu; Su, Guang-Liang; Sun, Zhi-Jun

doi:10.1021/acsnano.3c07828

Cited by 8 publications

(2 citation statements)

References 417 publications

(641 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the temperature on tumor regions in the AuNC@Bi 2 Se 3 + laser group reached 49. 3 °C, effectively ablating the tumor cells and inhibiting their malignant proliferation (Fig. 5B and C).…”

Section: In Vivo Anti-cancer Effects Of Aunc@bi 2 Sementioning

confidence: 94%

“…1,2 In recent years, a growing body of research has focused on lighttriggered therapeutic strategies against cancer based on nanomaterials. [3][4][5] Near-infrared (NIR) light-triggered therapeutic strategies, including photothermal therapy (PTT) and photodynamic therapy (PDT), can destroy tumor cells through local high temperature or in situ generation of reactive oxygen species (ROS). [6][7][8] These methods are particularly appealing due to their minimal systemic toxicity, non-invasive nature, and high selectivity towards cancer cells.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultra small gold nanoclusters supported on two-dimensional bismuth selenium nanosheets for synergistic photothermal and photodynamic tumor therapy

Li,

Fang,

Zeng

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: In Vivo Anti-cancer Effects Of Aunc@bi 2 Sementioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Ultra small gold nanoclusters supported on two-dimensional bismuth selenium nanosheets for synergistic photothermal and photodynamic tumor therapy

Li,

Fang,

Zeng

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression

Kaul,

Sanin,

Shi

et al. 2024

Pharmacol. Rep

View full text Add to dashboard Cite

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most difficult to treat tumors. The Src (sarcoma) inhibitor dasatinib (DASA) has shown promising efficacy in preclinical studies of PDAC. However, clinical confirmation could not be achieved. Overall, our aim was to deliver arguments for the possible reinitiating clinical testing of this compound in a biomarker-stratifying therapy trial for PDAC patients. We tested if the nanofunctionalization of DASA can increase the drug efficacy and whether certain Src members can function as clinical predictive biomarkers. Methods Methods include manufacturing of poly(vinyl alcohol) stabilized gold nanoparticles and their drug loading, dynamic light scattering, transmission electron microscopy, thermogravimetric analysis, Zeta potential measurement, sterile human cell culture, cell growth quantification, accessing and evaluating transcriptome and clinical data from molecular tumor dataset TCGA, as well as various statistical analyses. Results We generated homo-dispersed nanofunctionalized DASA as an AuNP@PVA-DASA conjugate. The composite did not enhance the anti-growth effect of DASA on PDAC cell lines. The cell model with high LYN expression showed the strongest response to the therapy. We confirm deregulated Src kinetome activity as a prevalent feature of PDAC by revealing mRNA levels associated with higher malignancy grade of tumors. BLK (B lymphocyte kinase) expression predicts shorter overall survival of diabetic PDAC patients. Conclusions Nanofunctionalization of DASA needs further improvement to overcome the therapy resistance of PDAC. LYN mRNA is augmented in tumors with higher malignancy and can serve as a predictive biomarker for the therapy resistance of PDAC cells against DASA. Studying the biological roles of BLK might help to identify underlying molecular mechanisms associated with PDAC in diabetic patients.

show abstract

Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy

Yousefiasl,

Ghovvati,

Mirshafiei

et al. 2025

Coordination Chemistry Reviews

View full text Add to dashboard Cite

Sniping Cancer Stem Cells with Nanomaterials

Cited by 8 publications

References 417 publications

Ultra small gold nanoclusters supported on two-dimensional bismuth selenium nanosheets for synergistic photothermal and photodynamic tumor therapy

Ultra small gold nanoclusters supported on two-dimensional bismuth selenium nanosheets for synergistic photothermal and photodynamic tumor therapy

Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression

Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy

Contact Info

Product

Resources

About