SNORD126 promotes HCC and CRC cell growth by activating the PI3K–AKT pathway through FGFR2

Fang, Xianlong; Yang, Dongmei; Luo, Hongping; Wu, Shuai; Wu, Dong; Xiao, Jing; Yuan, Sujing; Ni, Ai-Min; Zhang, Kang-Jian; Liu, Xinyuan; Chu, Liang

doi:10.1093/jmcb/mjw048

Cited by 77 publications

(86 citation statements)

References 54 publications

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“…Different superscripted lowercase letters indicate significant differences from each other (p < 0.05). EV, empty vector; FABP5, fatty acid binding proteins 5; Met, methionine; NC, negative control; siRNA, small interfering RNA; SE, standard error; SREBP-1c, sterol regulatory element-binding protein 1c [Color figure can be viewed at wileyonlinelibrary.com] show that amino acids, E2, and insulin stimulate SREBP-1c gene expression via PI3K signaling (Fang et al, 2017;X. Huang et al, 2017;Yecies et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

FABP5 is a critical regulator of methionine‐ and estrogen‐induced SREBP‐1c gene expression in bovine mammary epithelial cells

Zhou

et al. 2018

Journal Cellular Physiology

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The intracellular fatty acid-binding proteins (FABPs) are a well-conserved family that function as lipid chaperones. Ongoing studies are focused on identification of the mechanistic complexity and vast biological diversity of different isoforms of FABPs. However, the molecular mechanism of FABP5 in the regulation of milk fat synthesis in the mammary gland of dairy cows is still largely unknown. Here, we report that FABP5 acts as a critical regulator of terol response element-binding protein-1c (SREBP-1c) gene expression induced by methionine (Met) and estrogen (E2) in bovine mammary epithelial cells (BMECs). We observed that the expression of FABP5 was markedly higher in dairy cow mammary tissue during the lactating period than the puberty period and the dry period. FABP5 is located in the cytoplasm, and Met and E2 significantly increase the protein levels of FABP5 in BMECs. Using gene function study approaches, we revealed that FABP5 positively regulates SREBP-1c gene expression and promotes milk fat synthesis. We confirmed that FABP5 is required for Met- and E2-induced SREBP-1c gene expression and milk fat synthesis. We further uncovered that fatty acids are needed for FABP5-mediated SREBP-1c gene expression. Thus, our study demonstrates that FABP5 is a critical regulator of Met- and E2-induced SREBP-1c gene expression leading to milk fat synthesis.

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Section: Discussionmentioning

confidence: 99%

FABP5 is a critical regulator of methionine‐ and estrogen‐induced SREBP‐1c gene expression in bovine mammary epithelial cells

Zhou

et al. 2018

Journal Cellular Physiology

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“…Similarly, SNORD126 is up-regulated in hepatocellular carcinoma and colorectal cancer and upregulates genes involved in the PI3-AKT pathway [68]. Osteoarthritis is the most common degenerative disease of the joints, characterized by joint cartilage breakdown that affects about 4% of the population.…”

Section: Diseases Caused By Snorna Loss Indicate New Functionsmentioning

confidence: 99%

C/D‐box snoRNAs form methylating and non‐methylating ribonucleoprotein complexes: Old dogs show new tricks

et al. 2017

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C/D box snoRNAs (SNORDs) are an abundantly expressed class of short, non-coding RNAs that have been long known to perform 2′-O-methylation of rRNAs. However, approximately half of human SNORDs have no predictable rRNA targets, and numerous SNORDs have been associated with diseases that show no defects in rRNAs, among them Prader-Willi syndrome, Duplication 15q syndrome and cancer. This apparent discrepancy has been addressed by recent studies showing that SNORDs can act to regulate pre-mRNA alternative splicing, mRNA abundance, activate enzymes, and be processed into shorter ncRNAs resembling miRNAs and piRNAs. Furthermore, recent biochemical studies have shown that a given SNORD can form both methylating and non-methylating ribonucleoprotein complexes, providing an indication of the likely physical basis for such diverse new functions. Thus, SNORDs are more structurally and functionally diverse than previously thought, and their role in gene expression is under-appreciated. The action of SNORDs in non-methylating complexes can be substituted with oligonucleotides, allowing devising therapies for diseases like Prader-Willi syndrome.

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“…Of note, small nucleolar RNAs (snoRNAs), which are non-coding RNAs that are 60-300 nucleotides in length, were proposed to be closely associated with various human diseases, including cancer (11,12). Several studies have reported that certain snoRNAs act as diagnostic or prognostic biomarkers and as therapeutic targets for HCC (13,14). Several in vitro and in vivo studies indicated that certain snoRNAs are involved in the regulation of the genesis and biological behavior of HCC, including cell proliferation, migration, apoptosis, cell cycle and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Genomic analysis of small nucleolar RNAs identifies distinct molecular and prognostic signature in hepatocellular carcinoma

Yang

Lin

et al. 2018

Oncol Rep

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As one of the most lethal malignancies worldwide, hepatocellular carcinoma (HCC) has a high mortality rate, which is mainly due to the complex and multi-step aberrations in gene expression associated with it. Small nucleolar RNAs (snoRNAs), non-coding RNAs that are 60-300 nucleotides in length, have been proposed to be closely associated with numerous human diseases, including HCC. However, the current knowledge regarding their clinical significance and mechanistic roles in HCC is limited. The present study comprehensively analyzed the snoRNA expression profiles in HCC and identified several ones that were dysregulated. The potential regulatory mechanisms of these snoRNAs were assessed via gene functional enrichment analyses. Univariate and multivariate Cox regression analyses were performed to identify snoRNAs that are independently associated with the risk of mortality. Subsequently, a prognostic index (PI) for survival prediction was established, which may serve as a prognostic biomarker for patients with HCC (hazard ratio, 3.023; 95% confidence interval: 1.785-5.119; P<0.001). In addition, a series of bioinformatics analyses were performed to identify potential differences in the perturbation of pathways between high-and low-risk groups. The PI developed in the present study was determined to have a moderate predictive value regarding the clinical outcome for HCC patients.

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SNORD126 promotes HCC and CRC cell growth by activating the PI3K–AKT pathway through FGFR2

Cited by 77 publications

References 54 publications

FABP5 is a critical regulator of methionine‐ and estrogen‐induced SREBP‐1c gene expression in bovine mammary epithelial cells

FABP5 is a critical regulator of methionine‐ and estrogen‐induced SREBP‐1c gene expression in bovine mammary epithelial cells

C/D‐box snoRNAs form methylating and non‐methylating ribonucleoprotein complexes: Old dogs show new tricks

Genomic analysis of small nucleolar RNAs identifies distinct molecular and prognostic signature in hepatocellular carcinoma

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