Snoring and Sleep Apnea in Obese Adolescents: Effect of Long-term Weight Loss-Rehabilitation

Siegfried, Wolfgang; Siegfried, Alena; Rabenbauer, Maria; Hebebrand, Johannes

doi:10.1007/s11325-999-0083-7

Cited by 42 publications

(28 citation statements)

References 23 publications

(24 reference statements)

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“…This result is in agreement with the results of Siegfried et al and Verhulst et al, studies that also evaluated adolescents submitted to a weight loss therapy. 38,39 It is important to mention that SDB can worsen cognitive learning function. 33 Considering the age of the population studied, this might also have an important impact in school performance.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Corgosinho

Ackel-D’Elia

Tufik

et al. 2015

Metabolic Syndrome and Related Disorders

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Obesity is considered a chronic subinflammatory disease and is a risk factor for many diseases such as sleep-disordered breathing (SDB). Although the interaction between obesity and sleep has been explored, not much is known about SDB in the adolescent population. Thus, the aims of this study were, first, to verify the effect of 1 year of interdisciplinary therapy on inflammatory markers in SDB and without SDB and, second, to investigate the influence of SDB on the result of the therapy by comparing these groups. A total of 36 obese adolescents were enrolled; however, only 24 completed the therapy (SDB group, n=12; non-SDB obese group, n=12). Sleep, anthropometric, metabolic, and inflammatory profiles were evaluated at baseline and after the treatment. In both groups, the therapy was able to improve all anthropometric variables. Metabolic parameters such as insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI) were significantly improved only in non-SDB group. In both groups, the inflammatory state was significantly improved by the reduction in the leptin/adiponectin ratio. After the intervention, both groups no longer presented the hyperleptinemic state, favoring not only the inflammatory state, but also neuroendocrine regulation. Regarding the sleep parameter, the SDB group improved significantly in all respiratory events, and after therapy only four patients remained with SDB. Furthermore, there was an increase in sleep time. The lifestyle intervention was able to improve anthropometric, metabolic, and inflammatory parameters in both groups; however, the presence of SDB impaired better results. The data supported that the inclusion of SDB in the metabolic syndrome because of the link shown between them.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Corgosinho

Ackel-D’Elia

Tufik

et al. 2015

Metabolic Syndrome and Related Disorders

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“…Limited data from retrospective cohort studies generated from residential treatment centres or reports on bariatric surgery support this recommendation (class IV) [200][201][202]. The effects of weight loss on an outpatient basis have not been studied.…”

Section: Literature Reviewmentioning

confidence: 99%

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

et al. 2015

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This document summarises the conclusions of a European Respiratory Society Task Force on the diagnosis and management of obstructive sleep disordered breathing (SDB) in childhood and refers to children aged 2-18 years. Prospective cohort studies describing the natural history of SDB or randomised, double-blind, placebo-controlled trials regarding its management are scarce. Selected evidence (362 articles) can be consolidated into seven management steps. SDB is suspected when symptoms or abnormalities related to upper airway obstruction are present (step 1). Central nervous or cardiovascular system morbidity, growth failure or enuresis and predictors of SDB persistence in the long-term are recognised (steps 2 and 3), and SDB severity is determined objectively preferably using polysomnography (step 4). Children with an apnoea-hypopnoea index (AHI) >5 episodes·h, those with an AHI of 1-5 episodes·h −1 and the presence of morbidity or factors predicting SDB persistence, and children with complex conditions (e.g. Down syndrome and Prader-Willi syndrome) all appear to benefit from treatment (step 5). Treatment interventions are usually implemented in a stepwise fashion addressing all abnormalities that predispose to SDB (step 6) with re-evaluation after each intervention to detect residual disease and to determine the need for additional treatment (step 7). @ERSpublications Management of obstructive sleep disordered breathing in childhood should follow a stepwise approach

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“…[21–23] Same results are reflected in present cross sectional study, [Table 1] where the prevalence of snoring as surrogate of sleep disordered breathing was significantly lower in persons of BMI in normal range, as compared to those in range of pre obese or obese; but lack of significant difference, in prevalence of snoring among overweight and obese, points towards the fact that just by reduction of BMI from obese to pre obese range, is not enough to help the snorers. They in fact need to reduce their BMI to less than 25 kg/m 2 that is in normal range.…”

Section: Discussionmentioning

confidence: 99%

“…Sieqfried et al . [23] did their study on 38 extremely obese adolescents, and they concluded that weight reduction is good for OSA, but for snoring, its role might be overestimated. This difference could be explained by saying, that this study, was on comparatively lesser sample size, and subjects recruited were not adults.…”

Section: Discussionmentioning

confidence: 99%

Does ′weight reduction′ help all adult snorers?

et al. 2013

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Background:Obesity is now a global epidemic. Obese people are at higher risk of snoring. Weight reduction could influence the prevalence of snoring. Present study tried to find out, whether weight reduction is of benefit in all adult snorers.Materials and Methods:It is a cross sectional study, on 349 subjects (196 males and 153 females). They and their spouses were asked for snoring habits. Their neck circumference, height and weight was measured and Body mass index (BMI) was calculated, and they were classified into low normal, high normal, pre-obese and obese BMI groups. Prevalence rates of snoring in different groups were compared, to find out any statistically significant difference, between them.Results:Statistically significant difference, in prevalence rates of snoring was found, when obese and pre-obese group were compared with normal BMI group, separately. No significant difference was found in prevalence rates, when comparison was made between obese and pre-obese group. Difference in prevalence of snoring, was also not significant, when comparison was made between low normal and high normal BMI groups. Neck circumference of snorers was significantly more than the neck circumference of non-snorers in all BMI groups. Gender wise difference, in prevalence of snoring was also not significant.Conclusion:Body mass index target needs to be set at 25 kg/m2, in weight reduction programmes, to achieve clinically relevant response in a snorer. There is no need to put extra emphasis, on further reduction of BMI. Weight reduction, is not helpful in all adult snorers, especially those with normal BMI, where other causes of snoring, like fat around upper airways, need to be considered.

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Snoring and Sleep Apnea in Obese Adolescents: Effect of Long-term Weight Loss-Rehabilitation

Cited by 42 publications

References 23 publications

Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing

Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management

Does ′weight reduction′ help all adult snorers?

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