We establish Euclidean-type lower bounds for the codimension-1 Hausdorff measure of sets that separate points in doubling and linearly locally contractible metric manifolds. This gives a quantitative topological isoperimetric inequality in the setting of metric manifolds, in the sense that lower bounds for the codimension-1 measure of a set depend not on some notion of filling or volume but rather on in-radii of complementary components. As a consequence, we show that balls in a closed, connected, doubling, and linearly locally contractible metric n-manifold (M, d) with radius 0 < r ≤ diam(M ) have n-dimensional Hausdorff measure at least c · r n , where c > 0 depends only on n and on the doubling and linear local contractibility constants.