SNP analysis reveals estrogen receptor 1 (&amp;lt;i&amp;gt;ESR1&amp;lt;/i&amp;gt;) gene variants associated with laying traits in quails

Wu, Yan; Pan, Alexander; Pi, Jinsong; Pu, Yuejin; Du, Junzheng; Liang, Zhen-Hua; Shen, Jie

doi:10.5194/aab-58-441-2015

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…In the chicken ovary, expression of the ESR1 gene is higher than that of the ESR2 gene. ESR1 is reported to be associated with ovarian functions, especially during follicular development [83,84], and to be one of the candidate genes for traits related to egg production in chicken and quail [85,86]. This gene has also been be associated with reproductive traits in pigs and sheep [87,88].…”

Section: Genes Related To Growth and Reproductive Traitsmentioning

confidence: 99%

A genome-wide scan to identify signatures of selection in two Iranian indigenous chicken ecotypes

et al. 2021

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Background Various regions of the chicken genome have been under natural and artificial selection for thousands of years. The substantial diversity that exits among chickens from different geographic regions provides an excellent opportunity to investigate the genomic regions under selection which, in turn, will increase our knowledge about the mechanisms that underlie chicken diversity and adaptation. Several statistics have been developed to detect genomic regions that are under selection. In this study, we applied approaches based on differences in allele or haplotype frequencies (FST and hapFLK, respectively) between populations, differences in long stretches of consecutive homozygous sequences (ROH), and differences in allele frequencies within populations (composite likelihood ratio (CLR)) to identify inter- and intra-populations traces of selection in two Iranian indigenous chicken ecotypes, the Lari fighting chicken and the Khazak or creeper (short-leg) chicken. Results Using whole-genome resequencing data of 32 individuals from the two chicken ecotypes, approximately 11.9 million single nucleotide polymorphisms (SNPs) were detected and used in genomic analyses after quality processing. Examination of the distribution of ROH in the two populations indicated short to long ROH, ranging from 0.3 to 5.4 Mb. We found 90 genes that were detected by at least two of the four applied methods. Gene annotation of the detected putative regions under selection revealed candidate genes associated with growth (DCN, MEOX2 and CACNB1), reproduction (ESR1 and CALCR), disease resistance (S1PR1, ALPK1 and MHC-B), behavior pattern (AGMO, GNAO1 and PSEN1), and morphological traits (IHH and NHEJ1). Conclusions Our findings show that these two phenotypically different indigenous chicken populations have been under selection for reproduction, immune, behavioral, and morphology traits. The results illustrate that selection can play an important role in shaping signatures of differentiation across the genomic landscape of two chicken populations.

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Section: Genes Related To Growth and Reproductive Traitsmentioning

confidence: 99%

A genome-wide scan to identify signatures of selection in two Iranian indigenous chicken ecotypes

et al. 2021

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“…This approach enables more efficient breeding selection for egg production traits in chickens. Therefore, identification and application of potential candidate genes and associated genotypes can have significant economic implications and have become increasingly important in poultry breeding programs [ 27 , 44 , 48 ]. However, more candidate genes and single nucleotide polymorphisms (SNPs) are required for MAS in chicken breeding.…”

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confidence: 99%

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Niu

Tyasi

Qin

et al. 2017

The Journal of Veterinary Medical Science

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Estrogen receptors α (ESR1) and β (ESR2) play central roles in folliculogenesis and therefore in reproductive biology. In the present study, two single nucleotide polymorphisms (SNPs) were identified in the ESR1 and ESR2 genes using PCR-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing. One of the identified SNPs, a T1101C transition located within exon 4 of the ESR1 gene, was significantly associated with hen-housed egg production (HHEP) at 30, 43, 57 and 66 weeks of age (P<0.05), and egg weight (EW) at 30 weeks (P<0.05). Another SNP, a G1755A transition leading to a non-synonymous substitution (valine 459-to-isoleucine) located within exon 8 of the ESR2 gene, was also markedly correlated with the HHEP at 30, 43, 57 and 66 weeks of age (P<0.05), and EW at 30 weeks (P<0.05). A greater proportion of the additive variance was explained by the SNPs for most of the associated egg production traits (>1%). Furthermore, the results of the combined genotype-based association analysis supported the finding that the two SNPs were associated with the traits under a study. Taken together, our findings suggest that the two sequence variations in the ESR1 and ESR2 genes may provide promising genetic markers for the early selection and prediction of advantageous phenotypes in chicken breeding.

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“…We conclude from this that the estrogen receptor α (ESRα) gene has a positive and significant relationship with egg production. [18] indicated in his study on the single nucleotide polymorphism of estrogen receptor 1 (ESR1) gene and its association with productive traits of yellow Japanese quail, indicates that there was a significant correlation between estrogen receptor 1 gene (ESR1) and egg production. As for egg weight (g), we noticed from table (3) that there were no significant differences between three genotypes CC, CT, and TT, as egg weight for all three genotypes was 10.81, 11.37, and 10.80 g respectively.…”

Section: Effect Of Restriction Fragment Length Polymorphism (Rflp) Of...mentioning

confidence: 99%

“…[20] showed in their study on estrogen receptor gene 1 and 2 and their association with some productive traits of local Iraqi chickens using single nucleotide polymorphism technique, that estrogen receptor gene 1 (ESR1) does not significantly effect on weight of first egg (g) and weight at sexual maturity (g). While [18] indicated in his study on estrogen receptor 1 (ESR1) using single nucleotide polymorphisms (SNPs) and its association with productive traits of yellow Japanese quail that there was no significant correlation between estrogen receptor 1 (ESR1) gene and female weight at laying first egg (g). Table 3.…”

Section: Female Weight At Laying First Egg (G) Weight Of First Egg (G...mentioning

confidence: 99%

Genetic Polymorphism of Estrogen Receptor Alpha Gene (ESRα) and Its Effect on Production and Biochemical Traits of White Quails

Al-Hadeedy,

Mohammed,

Al-Tikriti

2023

IOP Conf. Ser.: Earth Environ. Sci.

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This study was conducted in the poultry field of Animal Production Department - College of Agriculture - University of Kirkuk for the period from 28/3/2022 to 15/1/2023, to determine the restriction fragment length polymorphism (RFLP) of alpha estrogen receptor gene (ESRα) and evaluation of some productive and biochemical traits of white Japanese quail, One-day-old quails were obtained from Animal Production Department - College of Agriculture, and they were reared for 35 days until reaching age of sexual maturity. Then they were randomly distributed to 30 families, with male and female for each family. The birds were fed on a diet with 20% crude protein and 2850 k.cal/kg metabolism energy of feed. At the end of the experiment, the female of each family was slaughtered and DNA was extracted from liver by using kit to determine the polymorphism of the length restriction fragment (RFLP) for estrogen receptor alpha gene (ESRα) and evaluation of some productive and biochemical traits by polymerase chain reaction (PCR) technology and the use of the restriction enzyme (EcoRI) and electrophoresis to determine the length of bundles of ESRα gene. The results of the study showed that the CC genotype resulting from the restriction fragment length polymorphism (RFLP) of estrogen receptor alpha (ESRα) gene had a significant effect on egg production of white Japanese quail compared with CT and TT genotypes, and CC and TT genotypes were superior to CT genotypes in estrogen level, while CC and CT genotypes were superior to the TT genotype in glucose level in blood serum of female white Japanese quail. The study recommended to selection CC and TT genotypes of estrogen receptor alpha (ESRα) gene because it is positively and significantly associated with egg production of white Japanese quail.

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SNP analysis reveals estrogen receptor 1 (<i>ESR1</i>) gene variants associated with laying traits in quails

Cited by 6 publications

References 16 publications

A genome-wide scan to identify signatures of selection in two Iranian indigenous chicken ecotypes

A genome-wide scan to identify signatures of selection in two Iranian indigenous chicken ecotypes

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Genetic Polymorphism of Estrogen Receptor Alpha Gene (ESRα) and Its Effect on Production and Biochemical Traits of White Quails

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