SNP‐Based Heritability Estimates of Common and Specific Variance in Self‐ and Informant‐Reported Neuroticism Scales

Realo, Anu; Most, Peter J. van der; Allïk, Jüri; Esko, Tõnu; Jeronimus, Bertus F.; Kööts–Ausmees, Liisi; Mõttus, René; Tropf, Felix C.; Snieder, Harold; Ormel, Johan

doi:10.1111/jopy.12297

Cited by 10 publications

(11 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…mother's tolerance and emotional warmth combined) was 21.4% ( p = .048). These analyses (step 1) were adjusted for G2 age and gender, and four genetic principal components to take into account any possible population stratification (Price et al., ; Realo et al., ).…”

Section: Results Of the Gcta‐greml Analysismentioning

confidence: 99%

“…Estimation of the phenotypic variance explained by the SNPs (h 2 ) was done by employing restricted maximum likelihood (GREML). Even though this method has recently been criticized (Krishna-Kumar, Feldman, Rehkopf, & Tuljapurkar, 2015), GCTA-GREML is generally seen as producing reliable and stable estimates of heritability (Realo et al, 2017;Vattikuti, Guo, & Chow, 2012;Yang et al, 2016). The logic of GCTA-GREML is that the extent to which phenotypic similarity between genetically unrelated individuals is associated with the degree of similarity in DNA markers indicates the heritability of the phenotype.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study

Dobewall

Savelieva

Seppälä

et al. 2018

Child Psychology Psychiatry

View full text Add to dashboard Cite

Background Genomic analysis of the child might offer new potential to illuminate human parenting. We examined whether offspring (G2) genome‐wide genotype variation (SNPs) is associated with their mother's (G1) emotional warmth and intolerance, indicating a gene–environment correlation. If this association is stronger than between G2′s genes and their emotional warmth and intolerance toward their own children, then this would indicate the presence of an evocative gene–environment correlation. To further understand how G1 mother's parenting has been evoked by genetically influenced characteristics of the child (G2), we examined whether child (G2) temperament partially accounted for the association between offspring genes and parental responses. Methods Participants were from the Young Finns Study. G1 mothers (N = 2,349; mean age 39 years) self‐reported the emotional warmth and intolerance toward G2 in 1980 when the participants were from 3 to 18 years old. G2 participants answered the same parenting scales in 2007/2012 (N = 1,378; mean age = 38 years in 2007; 59% female) when their children were on average 11 years old. Offspring temperament traits were self‐reported in 1992 (G2 age range 15–30 years). Estimation of the phenotypic variance explained by the SNPs of G2 was done by genome‐wide complex trait analysis with restricted maximum likelihood (GCTA‐GREML). Results Results showed that the SNPs of a child (G2) explained 22.6% of the phenotypic variance of maternal intolerance (G1; p‐value = .039). G2 temperament trait negative emotionality explained only 2.4% points of this association. G2 genes did not explain G1 emotional warmth or G2′s own emotional warmth and intolerance. However, further analyses of a combined measure of both G1 parenting scales found genetic effects. Parent or child gender did not moderate the observed associations. Conclusions Presented genome‐wide evidence is pointing to the important role a child plays in affecting and shaping his/her family environment, though the underlying mechanisms remain unclear.

show abstract

Section: Results Of the Gcta‐greml Analysismentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study

Dobewall

Savelieva

Seppälä

et al. 2018

Child Psychology Psychiatry

View full text Add to dashboard Cite

show abstract

“…Because negative affectivity appears to be a central theme binding Neuroticism facets together (Lucas et al, 2000 ; Markon et al, 2005 ), it can be expected that N5: Impulsiveness is more peripheral and less strongly connected with the other subscales of Neuroticism. Genetic evidence also supports the idea that different facets may not have an identical genetic background (Realo et al, 2017 ). There are also several different forms of impulsive behavior, which, due to confusion, can cause spurious correlations on the “wrong” factors (Sharma et al, 2014 ).…”

Section: Discussionmentioning

confidence: 60%

Unusual Configurations of Personality Traits Indicate Multiple Patterns of Their Coalescence

2018

Self Cite

View full text Add to dashboard Cite

It is widely accepted that the Five Factor Model (FFM) is a satisfactory description of the pattern of covariations among personality traits, which supposedly fits, more or less adequately, every individual. As an amendment to the FFM, we propose that the customary five-factor structure is only a near-universal, because it does not fit all individuals but only a large majority of them. Evidences reveal a small minority of participants who have an unusual configuration of personality traits, which is clearly recognizable, both in self- and observer-ratings. We identified three types of atypical configurations of personality traits, characterized mainly by a scatter of subscale scores within each of the FFM factors. How different configurations of personality traits are formed, persist, and function needs further investigation.

show abstract

“…For example, researchers may correlate both self-report and informantrating scores to some outcome variable such as diabetes (Čukić et al, 2016) or dietary habits (Mõttus et al, 2012) and then compare the findings, assuming that converging findings would constitute a quasi-replication or at least provide stronger evidence than findings based on one rating type alone. In the same vain, genetic variance in personality traits may be investigated in both rating types (e.g., Realo et al, 2017). For such attempts, metric MI (equivalence of factor loadings) suffices, and our findings suggest that most scales indeed display equivalent factor loadings across rating types.…”

Section: Discussionmentioning

confidence: 74%

Do Self-Reports and Informant-Ratings Measure the Same Personality Constructs?

Mõttus

Allïk

Realo

2020

European Journal of Psychological Assessment

Self Cite

View full text Add to dashboard Cite

Abstract. Personality researchers often supplement or substitute self-reports with ratings from knowledgeable informants, at least implicitly assuming that the same constructs are being measured regardless of the source of ratings. However, measurement invariance (MI) of personality constructs across these rating types has rarely been empirically tested. Here, this was done for the Five-Factor Model domains and their 30 facets ( N = 3,253). All facets and all domains but Agreeableness met the level of invariance (metric MI) required for comparing the relative standings of individuals across self-reports and informant-ratings, which is what researchers mostly do. However, ten facets and the Agreeableness domain failed to achieve the level of invariance (scalar MI) recommended when comparing mean scores. In conclusion, self-reports and informant-ratings appear to measure similar constructs for most research purposes.

show abstract

SNP‐Based Heritability Estimates of Common and Specific Variance in Self‐ and Informant‐Reported Neuroticism Scales

Abstract: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene × Environment interaction across cohorts.

Cited by 10 publications

References 89 publications

Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study

Gene–environment correlations in parental emotional warmth and intolerance: genome‐wide analysis over two generations of the Young Finns Study

Unusual Configurations of Personality Traits Indicate Multiple Patterns of Their Coalescence

Do Self-Reports and Informant-Ratings Measure the Same Personality Constructs?

Contact Info

Product

Resources

About