SNPs, adipokynes and adiposity in children with asthma

Machado, M E; Pôrto, Luís Cristóvão; Galvão, M G Alves; Sant’Anna, Clemax Couto; Silva, José Roberto Lapa e

doi:10.1080/02770903.2022.2077218

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Moreover, Sutherland et al (2009) showed high leptin levels in overweight and obese individuals, but no associations between leptin levels and a diagnosis of asthma, or some biomarkers, such as the bronchodilator response or FEV1/FVC ratio [58]. In children, a relationship between obesity and asthma has also been found via high leptin levels and a low adiponectin concentration in blood [59], suggesting that those adipokines, together with the BMI, may be potential predictive biomarkers for asthma [60].…”

Section: Discussionmentioning

confidence: 96%

Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis

Sánchez-Ortega

Jiménez‐Cortegana

Ruiz

et al. 2022

IJMS

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Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of asthma. Adipose tissue secretes proinflammatory cytokines and mediators, including leptin, which may promote the development and severity of asthma in obese patients. This study is a systematic review and a meta-analysis based on the relationship between leptin and asthma during obesity. MEDLINE, Cochrane, EMBASE and CINAHL databases were used. Data heterogeneity was analyzed using Cochran’s Q and treatment effect with the DerSimonian and Laird method. Random effect analyses were carried out to test data sensitivity. Asymmetry was estimated using Begg’s and Egger’s tests. All studies showed significant differences in leptin levels. The effect of the measures (p < 0.001), data sensitivity (p < 0.05) and data asymmetry were statistically significant, as well as tBegg’s test (p = 0.010) and Egge’s test (p < 0.001). Despite the existing limiting factors, the results of this study support the relevant role of leptin in the pathophysiology of asthma in obese subjects. Nevertheless, further studies are needed to obtain better insight in the relationship between leptin and asthma in obesity.

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Section: Discussionmentioning

confidence: 96%

Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis

Sánchez-Ortega

Jiménez‐Cortegana

Ruiz

et al. 2022

IJMS

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“…In the study by Machado et al, it was found that leptin may be a potential predictor of asthma control in children. A weak predictive value was shown for BMI and adiponectin [43].…”

Section: Relationship Between Respiratory Disorders and Obesity In Ch...mentioning

confidence: 93%

Beyond the Metabolic Syndrome: Non-Obvious Complications of Obesity in Children

Kozioł-Kozakowska,

Januś,

Stępniewska

et al. 2023

Children

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Obesity is currently one of the most significant public health challenges worldwide due to the continuous increase in obesity rates among children, especially younger children. Complications related to obesity, including serious ones, are increasingly being diagnosed in younger children. A search was performed from January 2023 to September 2023 using the PubMed, Cochrane Library, Science Direct, MEDLINE, and EBSCO databases. The focus was on English-language meta-analyses, systematic reviews, randomized clinical trials, and observational studies worldwide. Four main topics were defined as follows: disorders of glucose metabolism; liver disease associated with childhood obesity; the relationship between respiratory disorders and obesity in children; and the effects of obesity on the hypothalamic–pituitary–gonadal axis and puberty. Understanding potential complications and their underlying mechanisms can expedite the diagnostic process and enhance the effectiveness of treatment. We aspire that this study will bring insight into the often-overlooked complications associated with obesity.

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“…Low adiponectin level is especially found in female obese asthmatics as compared to men which imply that adiponectin responds differently in both sexes having a common type of asthma in obese phenotype (Sood et al, 2008). It has recently been revealed that a high BMI and a low level of adiponectin in children may suggest severe asthma (Machado et al, 2022). Although there have been reports of the protective effect of adiponectin on obese asthmatics, however, there are also reports of the negative impacts of adiponectin in the same condition.…”

Section: Anti-inflammatory Adipokines 2221 Adiponectinmentioning

confidence: 99%

Herbal medicine for the treatment of obesity-associated asthma: a comprehensive review

Das

Pathak

et al. 2023

Front. Pharmacol.

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Obesity is fast growing as a global pandemic and is associated with numerous comorbidities like cardiovascular disease, hypertension, diabetes, gastroesophageal reflux disease, sleep disorders, nephropathy, neuropathy, as well as asthma. Studies stated that obese asthmatic subjects suffer from an increased risk of asthma, and encounter severe symptoms due to a number of pathophysiology. It is very vital to understand the copious relationship between obesity and asthma, however, a clear and pinpoint pathogenesis underlying the association between obesity and asthma is scarce. There is a plethora of obesity-asthma etiologies reported viz., increased circulating pro-inflammatory adipokines like leptin, resistin, and decreased anti-inflammatory adipokines like adiponectin, depletion of ROS controller Nrf2/HO-1 axis, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) associated macrophage polarization, hypertrophy of WAT, activation of Notch signaling pathway, and dysregulated melanocortin pathway reported, however, there is a very limited number of reports that interrelates these pathophysiologies. Due to the underlying complex pathophysiologies exaggerated by obese conditions, obese asthmatics respond poorly to anti-asthmatic drugs. The poor response towards anti-asthmatic drugs may be due to the anti-asthmatics approach only that ignores the anti-obesity target. So, aiming only at the conventional anti-asthmatic targets in obese-asthmatics may prove to be futile until and unless treatment is directed towards ameliorating obesity pathogenesis for a holistic approach towards amelioration of obesity-associated asthma. Herbal medicines for obesity as well as obesity-associated comorbidities are fast becoming safer and more effective alternatives to conventional drugs due to their multitargeted approach with fewer adverse effects. Although, herbal medicines are widely used for obesity-associated comorbidities, however, a limited number of herbal medicines have been scientifically validated and reported against obesity-associated asthma. Notable among them are quercetin, curcumin, geraniol, resveratrol, β-Caryophyllene, celastrol, tomatidine to name a few. In view of this, there is a dire need for a comprehensive review that may summarize the role of bioactive phytoconstituents from different sources like plants, marine as well as essential oils in terms of their therapeutic mechanisms. So, this review aims to critically discuss the therapeutic role of herbal medicine in the form of bioactive phytoconstituents against obesity-associated asthma available in the scientific literature to date.

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SNPs, adipokynes and adiposity in children with asthma

Cited by 5 publications

References 22 publications

Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis

Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis

Beyond the Metabolic Syndrome: Non-Obvious Complications of Obesity in Children

Herbal medicine for the treatment of obesity-associated asthma: a comprehensive review

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