SNPs at 3'-UTR of the bovine CDIPT gene associated with Qinchuan cattle meat quality traits

Cz, Fu; H, Wang; Cg, Mei; Jl, Wang; Bj, Jiang; Ma, Xiang; Hb, Wang; Chen, Gong; Ls, Zan

doi:10.4238/2013.march.13.6

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…The Osteocrin gene might represent an important factor, as it is involved in the conversion of glucose to fatty acids via the regulation of glucose metabolism. The association of polymorphism with production traits has been reported by several studies previously published Ujan et al, 2011;Fu et al, 2013). The results of the current study showed that A85C SNP was associated with back fat thickness; whereas T335C was associated with both back fat thickness and loin muscle area (Table 3).…”

Section: Resultssupporting

confidence: 76%

Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle

Adoligbé

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Here, we detected 2 SNPs, A85C and T335C, that were located on the 3rd exon and the 3 untranslated regions of the bovine Osteocrin gene, respectively, using 413 Qinchuan cattle DNA samples. PCR-SSCP and DNA sequencing methods were specifically used. Three genotypes (AA, AC, and CC) were found at A85C; yet, only 2 genotypes (TC and CC) were found at T335C. Association analysis showed that both loci were associated with certain meat quality traits, including back fat thickness and loin muscle area. At the A85C locus, individuals with the CC genotype had greater back fat thickness. In comparison, at the T335C locus, individuals with the TC genotype had greater back fat thickness and a larger loin muscle area. Therefore, these 2 SNPs could be used as genetic markers to enhance Qinchuan cattle breeding programs.

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Section: Resultssupporting

confidence: 76%

Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle

Adoligbé

et al. 2015

Genet. Mol. Res.

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“…Using the candidate gene approach, previous studies have investigated the association of important economic traits, such as growth (Gao et al, 2011), reproduction , and meat quality traits (Fu et al, 2013), to identify useful genetic markers. This study provides the first report of 3 novel SNPs of the bovine SMO gene, which are expected to extend the spectrum of genetic variation of the bovine SMO gene, and contribute to our knowledge about bovine genetic resources for breeding programs.…”

Section: Discussionmentioning

confidence: 99%

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Zhang¹,

Li²,

Fu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Beef cattle breeding programs focus on improving important economic traits, including growth rates, and meat quantity and quality. Molecular marker-assisted selection based on genetic variation represents a potential method for breeding genetically improved livestock with better economic traits. Smoothened (SMO) protein is a signal transducer that contributes to the regulation of both osteogenesis and adipogenesis through the hedgehog pathway. In this study, we detected polymorphisms in the bovine SMO gene of Qinchuan cattle, and we analyzed their associations with body measurement traits (BMTs) and meat quality traits (MQTs). Using DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism, 3 novel single nucleotide polymorphisms were identified in the SMO gene of 562 cattle: 1 G > C mutation on exon 9 (G21234C) and 2 C > T mutations on exon 11 (C22424T and C22481T). Association analysis showed that polymorphisms on both the G21234C and C22424T loci significantly affected certain BMTs and MQTs (P < 0.05 or P < 0.01), whereas those on the C22481T locus did not (P > 0.05). Therefore, the SMO gene could be used as a candidate gene to alter BMTs and MQTs in Qinchuan cattle or for marker-assisted selection to breed cattle with superior BMTs and MQTs.

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“…Medium values of SNP polymorphism for the characteristics above mentioned indicate its potential use as a molecular marker (Fu et al, 2013). Electropherogram and capillary electrophoresis gel for G>T mutation in BMP4 gene are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 98%

Association between BMP4 gene polymorphism and in vitro embryo production traits in Gyr cows

Ortiz

Quirino

Silva

et al. 2015

Rev Colomb Cienc Pecu

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Original Articles SummaryBackground: candidate genes and their polymorphisms have been associated with traits of economic interest in cattle, representing an important strategy for genetic improvement of complex traits. Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGFβ) superfamily, which is involved with several events of embryonic, fetal, and adult development in vertebrates. Objective: the aim of this study was to evaluate the degree of association between polymorphism in the BMP4 gene (guanine for thymine-G>T, SNP rs109778173) and the performance of Gyr oocyte donors, including the rate of cumulus-oophorus complex obtained in each session of follicular aspiration (OPU), embryo development, and pregnancy rates. Methods: DNA was extracted from hair follicles from 50 oocyte donors and genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data from 212 OPU-IVP sessions was collected, and the following traits were associated with BMP4 polymorphism (SNP rs109778173): number and ratio of viable cumulus-oophorus complexes; number of cleaved embryos at day 4 of culture; number of transferable embryos at day 7 of culture, and pregnancies on days 30 and 60 after embryo transfer. Results: the studied BMP4 polymorphism was significantly associated (p<0.01) with the number and ratio of viable cumulus-oocyte complexes, and the ratio of pregnancies at 30 days. Conclusion: the GT genotype (SNP rs109778173) was associated with inferior performance regarding OPU-IVP traits. This finding suggests

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SNPs at 3'-UTR of the bovine CDIPT gene associated with Qinchuan cattle meat quality traits

Cited by 7 publications

References 13 publications

Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle

Polymorphisms of the Osteocrin gene and its association with meat quality traits in Qinchuan cattle

Effects of bovine SMO gene polymorphisms on the body measurement and meat quality traits of Qinchuan cattle

Association between BMP4 gene polymorphism and in vitro embryo production traits in Gyr cows

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