SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Abstract

We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population

“…Several previous studies have reported the association between XPG gene polymorphisms and development of gastric cancer (Hussain et al, 2009;Duan et al, 2012;He et al, 2012;Yang et al, 2012). He et al (2012) conducted a case-control study with 125 gastric cancer and 1196 cancer-free controls and reported that the XPG polymorphisms may contribute to the risk of gastric cancer.…”

Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

“…Previous studies have examined the association between ERCC5rs2094258 and rs751402 polymorphisms and the development of certain malignancies, including breast and gastric cancers, salivary gland tumors, and oral squamous cell carcinoma (Duan et al, 2012;Yang et al, 2012;Zavras et al, 2012;Meng et al, 2013;Na et al, 2015;Wang et al, 2015). For instance, Duan et al (2012) and Yang et al (2012) both reported that these polymorphisms contribute to the development of gastric cancer.…”

“…Duan et al (2012) conducted an investigation into the association between these two ERCC5 promoter SNPs and gastric cancer in a Chinese population, concluding that rs751402 does affect the risk of developing this malignancy. In another Chinese study of 337 newly diagnosed gastric cancer cases and 347 healthy controls, Yang et al (2012) found that rs2094258 is associated with increased risk of this disease. However, in the present work, we failed to establish an association between ERCC5 rs2094258 and rs751402 polymorphisms and development of gastric cancer among Chinese patients and controls.…”

“…For instance, Duan et al (2012) and Yang et al (2012) both reported that these polymorphisms contribute to the development of gastric cancer. Zavras et al (2012) carried out a study of 575 oral squamous cell carcinoma patients and 575 controls, finding the CC genotype of the ERCC5 rs751402 variant to be associated with decreased risk of this cancer.…”

“…Only two studies have examined the association between these genetic variants and development of gastric cancer (Duan et al, 2012;Yang et al, 2012). Duan et al (2012) conducted an investigation into the association between these two ERCC5 promoter SNPs and gastric cancer in a Chinese population, concluding that rs751402 does affect the risk of developing this malignancy.…”