SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy

You, Yun; Li, Wanzhen; Zhang, Sulin; Hu, Bin; Li, Yuexuan; Li, Haidong; Tang, Huanhuan; Li, Qianwen; Guan, Yunyun; Liu, Lixin; Bao, Weilian; Shen, X. Y.

doi:10.1016/j.jhep.2018.01.038

Cited by 68 publications

(60 citation statements)

References 57 publications

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“…Numerous studies have shown that autophagy has inhibitory effects on steatosis, inflammatory response, and hepatocyte apoptosis during ALD [65,66,67,68]. Moreover, research haa shown that various pathways, such as AMPK-Forkhead box O3 (FOXO3A) axis, sorting nexin 10 (SNX10)/chaperone, ALDH2, cannabinoid receptor 2 can induce autophagy to prevent alcoholic liver damage [61,69,70,71,72] (Figure 2).…”

Section: Pathogenesis Of Aldmentioning

confidence: 99%

Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease

Kong

Chandimali

Han

et al. 2019

IJMS

141

110

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Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis, steatohepatitis, chronic hepatitis with liver fibrosis or cirrhosis, and hepatocellular carcinoma. However, the mechanisms behind the pathogenesis of alcoholic liver disease are extremely complicated due to the involvement of immune cells, adipose tissues, and genetic diversity. Clinically, the diagnosis of ALD is not yet well developed. Therefore, the number of patients in advanced stages has increased due to the failure of proper early detection and treatment. At present, abstinence and nutritional therapy remain the conventional therapeutic interventions for ALD. Moreover, the therapies which target the TNF receptor superfamily, hormones, antioxidant signals, and MicroRNAs are used as treatments for ALD. In particular, mesenchymal stem cells (MSCs) are gaining attention as a potential therapeutic target of ALD. Therefore, in this review, we have summarized the current understandings of the pathogenesis and diagnosis of ALD. Moreover, we also discuss the various existing treatment strategies while focusing on promising therapeutic approaches for ALD.

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Section: Pathogenesis Of Aldmentioning

confidence: 99%

Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease

Kong

Chandimali

Han

et al. 2019

IJMS

141

110

View full text Add to dashboard Cite

show abstract

“…Based on analogies with studies performed in zebrafish and immortalized HeLa cells [72], SNX10 is thought to localize to endosomes and has been speculated to facilitate in the post-TGN sorting and/or trafficking of V-ATPases to the RB [66]. More recently, the function of SNX10 has been expanded to the trafficking and secretion of MMP9 [73] and chaperone-mediated autophagy [74]. Precisely how SNX10 modulates these diverse function(s) in osteoclasts warrants further investigation.…”

Section: Sorting Nexins In Osteoclasts: the Emerging Role Of Snx10mentioning

confidence: 99%

Membrane trafficking in osteoclasts and implications for osteoporosis

Ribet

Pavlos

2019

Biochemical Society Transactions

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Osteoclasts are large multinucleated cells exquisitely adapted to resorb bone matrix. Like other eukaryotes, osteoclasts possess an elaborate ensemble of intracellular organelles through which solutes, proteins and other macromolecules are trafficked to their target destinations via membrane-bound intermediaries. During bone resorption, membrane trafficking must be tightly regulated to sustain the structural and functional polarity of the osteoclasts’ membrane domains. Of these, the ruffled border (RB) is most characteristic, functioning as the osteoclasts' secretory apparatus. This highly convoluted organelle is classically considered to be formed by the targeted fusion of acidic vesicles with the bone-facing plasma membrane. Emerging findings disclose new evidence that the RB is far more complex than previously envisaged, possessing discrete subdomains that are serviced by several intersecting endocytic, secretory, transcytotic and autophagic pathways. Bone-resorbing osteoclasts therefore serve as a unique model system for studying polarized membrane trafficking. Recent advances in high-resolution microscopy together with the convergence of genetic and cell biological studies in humans and in mice have helped illuminate the major membrane trafficking pathways in osteoclasts and unmask the core molecular machinery that governs these distinct vesicle transport routes. Among these, small Rab GTPases, their binding partners and members of the endocytic sorting nexin family have emerged as critical regulators. This mini review summarizes our current understanding of membrane trafficking in osteoclasts, the key molecular participants, and discusses how these transport machinery may be exploited for the development of new therapies for metabolic disorders of bone-like osteoporosis.

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“…CMA targets interferon-alpha receptor chain-1 for degradation, dampens hepatic innate immunity, and disrupts interferon signaling pathways [ 151 ]. CMA is also observed in patients with ALD or MAFLD [ 152 , 153 ]. Altering interferon signaling may contribute to ALF-associated acute HAV infection.…”

Section: Possible Molecular Mechanism Of the Development Of Aclf mentioning

confidence: 99%

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Sasaki

Masuzaki

Takahashi

et al. 2020

IJMS

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Hepatitis A virus (HAV) infection occasionally leads to a critical condition in patients with or without chronic liver diseases. Acute-on-chronic liver disease includes acute-on-chronic liver failure (ACLF) and non-ACLF. In this review, we searched the literature concerning the association between HAV infection and chronic liver diseases in PubMed. Chronic liver diseases, such as metabolic associated fatty liver disease and alcoholic liver disease, coinfection with other viruses, and host genetic factors may be associated with severe hepatitis A. It is important to understand these conditions and mechanisms. There may be no etiological correlation between liver failure and HAV infection, but there is an association between the level of chronic liver damage and the severity of acute-on-chronic liver disease. While the application of an HAV vaccination is important for preventing HAV infection, the development of antivirals against HAV may be important for preventing the development of ACLF with HAV infection as an acute insult. The latter is all the more urgent given that the lives of patients with HAV infection and a chronic liver disease of another etiology may be at immediate risk.

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SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy

Cited by 68 publications

References 57 publications

Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease

Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease

Membrane trafficking in osteoclasts and implications for osteoporosis

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

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