SO-12 Multicentre validation of an immune-inflammation-based nomogram to predict survival in western resectable gastroesophageal adenocarcinoma: The NOMOGAST

Abstract

both questionnaires and verbal interviews. Incident cases were identified by linkage with routinely collected hospital inpatient and cancer registry data for England, Scotland and Wales. Primary clinical outcomes were GORD without oesophagitis, GORD with oesophagitis (reflux oesophagitis), Barrett's oesophagus and oesophageal adenocarcinoma. The effects of heavy manual activity on disease risk were estimated using Cox proportional hazard regression adjusted for multiple risk factors and stratified by socioeconomic status.Results: Between 2006 and 2010, 502 men and 524 women were enrolled. Main analyses were limited to the working population with a full set of variables of interest (n¼266, 453). Compared to jobs with low levels of heavy manual activity, high-level jobs had increased hazard ratios (HRs) for GORD (1.20, 95% CI 1.11-1.30), reflux oesophagitis (1.17, 95% CI 1.04-1.31) and Barrett's oesophagus (1.13, 95% CI 0.98-1.32), but not oesophageal adenocarcinoma (0.91 95% CI 0.54-1.56). Conclusion:High levels of occupational heavy manual activity could be used as a new risk factor for GORD and reflux oesophagitis, the precursor diseases of oeosphageal adenocarcinoma.Legal entity responsible for the study: The authors.