Sobre escravos e genes: “origens” e “processos” nos estudos da genética sobre a população brasileira

Calvo-González, Elena

doi:10.1590/s0104-59702014000400003

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…The genetic background of the Brazilian population is quite complex to analyze, given the significant admixture between European, African, and indigenous individuals and the history of invasions, migrations, and forced slavery [14]. Moreover, Ceará state was the first state that freed slaves in Brazil, with a new flow of migration and interaction.…”

Section: Discussionmentioning

confidence: 99%

Human TMPRSS2 and ACE2 Genetic Variability on COVID-19 Outcomes in Patients From Brazil

Mesquita,

Da Silva,

De Oliveira

et al. 2023

Preprint

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Angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are recognized as entry proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and recently their Single Nucleotide Polymorphisms (SNP) have been studied in different populations to elucidate the impact on disease. The aim of this study was to evaluate the genetic SNP of ACE2 (rs35803318) and TMPRSS2 (rs2070788) genes in COVID-19 patients from Northeast Brazil compared with global populations, as well as the expression quantitative trait locus (eQTL). For ACE2 (rs35803318), we found 92.6% CC, 3.4% CT, and 4.0% TT genotype carriers in SARS-CoV-2-positive patients. Surprisingly, only the genotype frequencies of ACE2 SNP were not in Hardy-Weinberg equilibrium. For TMPRSS2 rs2070788, we found 22.3% GG, 50.7% AG, and 27% AA genotype carriers in SARS-CoV-2-positive patients. The expression quantitative trait loci (eQTLs) revealed that rs35803318 was associated with an altered PIR gene expression, and rs2070788 was found eQTLs association only with lung tissue. No significant association was identified between the genotype distribution of SNPs and the 'patient's outcome. In conclusion, our results suggest that ACE2 and TMPRSS2 may not be protective factors for global populations, including the Brazilian population, since the presence of SNPs does not affect the 'patient's outcome as described by other studies.

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Section: Discussionmentioning

confidence: 99%

Human TMPRSS2 and ACE2 Genetic Variability on COVID-19 Outcomes in Patients From Brazil

Mesquita,

Da Silva,

De Oliveira

et al. 2023

Preprint

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Epistemologias do Sul e Saúde Coletiva: diálogos sobre Saúde da População Negra no cenário brasileiro

Lopes

2022

Semin. Cienc. Soc. Hum.

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Este artigo refere-se à aula ministrada no curso de Serviço Social (UFBA) sobre Epistemologias do Sul e vem com o objetivo de dialogar e contextualizar como, historicamente, as reinvindicações e atuação frente às negligências à Saúde da População Negra no cenário pré e pós-abolicionista, comungam com os ideários e ações que constituíram o Movimento Brasileiro de Reforma Sanitária. Sob a luz da perspectiva histórica de consolidação do Sistema Único de Saúde (SUS) e dos apontamentos dos movimentos sociais negros e das normativas internacionais de acesso à saúde como direito fundamental, ressalto a importância das discussões sobre raça, racismo e saúde para o fortalecimento das ações empreendidas em prol de um SUS equânime. Ainda sobre a Saúde da População Negra, desloco os olhares para as práticas que evidenciam um grande esforço contra-hegemônico na garantia de direitos e na redução das graves iniquidades raciais vivenciadas pela população negra dentro do Sistema Único de Saúde.

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Sobre escravos e genes: “origens” e “processos” nos estudos da genética sobre a população brasileira

Cited by 2 publications

References 27 publications

Human TMPRSS2 and ACE2 Genetic Variability on COVID-19 Outcomes in Patients From Brazil

Human TMPRSS2 and ACE2 Genetic Variability on COVID-19 Outcomes in Patients From Brazil

Epistemologias do Sul e Saúde Coletiva: diálogos sobre Saúde da População Negra no cenário brasileiro

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