Sobrecarga sistólica intermitente promove melhor desempenho miocárdico em animais adultos

Miana, Leonardo Augusto; Assad, Renato S.; Abduch, Maria Cristina Donadio; Gomes, Guiomar Nascimento; Nogueira, Ananda Rigo; Oliveira, Fernanda Santos de; Telles, Bruna Lopes; Souto, Maria Teresa; Silva, Gustavo J.; Stolf, Noedir Antônio Groppo

doi:10.1590/s0066-782x2010005000105

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…According to the authors' experience, the method is useful to follow-up myocardial hypertrophy and failure 31,32,12 . …”

Section: Final Considerationsmentioning

confidence: 99%

The Echocardiography in the Cardiovascular Laboratory: A Guide to Research with Animals

Abduch¹,

Assad²,

Mathias³

et al. 2013

Arquivos Brasileiros De Cardiologia

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The feasibility and potential for the morphological and hemodynamic investigation of the heart has been increasing the use of the echocardiography in the research setting. Additionally, the development of new technologies, like the real time 3D echocardiography and speckle tracking, demands validation throughout experimental studies before being instituted in the clinical setting.This paper aims to provide information concerning the particularities of the echocardiographic examination in quadruped mammals, targeting the experimental research.

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“…According to the authors' experience, the method is useful to follow-up myocardial hypertrophy and failure 31,32,12 . …”

Section: Final Considerationsmentioning

confidence: 99%

The Echocardiography in the Cardiovascular Laboratory: A Guide to Research with Animals

Abduch¹,

Assad²,

Mathias³

et al. 2013

Arquivos Brasileiros De Cardiologia

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“…Previous studies have demonstrated a better myocardial performance index for the ventricle subjected to intermittent training. [9,22] Several mechanisms have been proposed to explain the better performance of the ventricle that is intermittently trained. We speculate that it may be associated to the periods of rest and, consequently, to a lesser extent of oxidative process and damage to cardiomyocytes and collagen matrix.…”

Section: Discussionmentioning

confidence: 99%

Reversible pulmonary trunk banding: Myocardial vascular endothelial growth factor expression in young goats submitted to ventricular retraining

Assad

Rocha²,

Aiello

et al. 2020

PLoS ONE

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BackgroundVentricle retraining has been extensively studied by our laboratory. Previous studies have demonstrated that intermittent overload causes a more efficient ventricular hypertrophy. The adaptive mechanisms involved in the ventricle retraining are not completely established. This study assessed vascular endothelial growth factor (VEGF) expression in the ventricles of goats submitted to systolic overload. OPEN ACCESS Citation: Assad RS, Rocha EAV, Aiello VD, Meniconi TA, Abduch MCD, Thomaz PG, et al. (2020) Reversible pulmonary trunk banding: Myocardial vascular endothelial growth factor expression in young goats submitted to ventricular retraining. PLoS ONE 15(2): e0217732. https://doi.Intermittent systolic overload promotes greater upregulation of VEGF expression in the subpulmonary ventricle, an adaptation that provides a mechanism for increased myocardial perfusion during the rapid myocardial hypertrophy of young goats.

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“…The goats were prepared for the sterile procedure, as described in previous studies [ 11 , 12 ] . For animals in the Traditional group, pulmonary trunk (PT) banding was performed with cardiac tape (Polysuture, São Sebastião do Paraíso, MG), positioned about 10 mm above the valve.…”

Section: Methodsmentioning

confidence: 99%

“…The adult model device was developed in collaboration with SILIMED ( Indústria de silicone e instrumental médico-cirúrgico e hospitalar Ltda. , Rio de Janeiro, RJ), as previously published [ 11 , 12 ] . It has an outer diameter of 24 mm and is 6 mm wide.…”

Section: Methodsmentioning

confidence: 99%

Reversible pulmonary trunk banding. IX. G6PD activity of adult goat myocardium submitted to ventricular retraining

Assad¹,

Miana²,

Fonseca‐Alaniz³

et al. 2013

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveIncreased glucose 6-phosphate dehydrogenase activity has been demonstrated in heart failure. This study sought to assess myocardial glucose 6-phosphate dehydrogenase activity in retraining of the subpulmonary ventricle of adult goats. MethodsEighteen adult goats were divided into three groups: traditional (fixed banding), sham, and intermittent (adjustable banding, daily 12-hour systolic overload). Systolic overload (70% of systemic pressure) was maintained during a 4-week period. Right ventricle, pulmonary artery and aortic pressures were measured throughout the study. All animals were submitted to echocardiographic and hemodynamic evaluations throughout the protocol. After the study period, the animals were killed for morphological and glucose 6-phosphate dehydrogenase activity assessment.ResultsA 55.7% and 36.7% increase occurred in the intermittent and traditional right ventricle masses, respectively, when compared with the sham group (P<0.05), despite less exposure of intermittent group to systolic overload. No significant changes were observed in myocardial water content in the 3 groups (P=0.27). A 37.2% increase was found in right ventricle wall thickness of intermittent group, compared to sham and traditional groups (P<0.05). Right ventricle glucose 6-phosphate dehydrogenase activity was elevated in the traditional group, when compared to sham and intermittent groups (P=0.05).ConclusionBoth study groups have developed similar right ventricle hypertrophy, regardless less systolic overload exposure of intermittent group. Traditional systolic overload for adult subpulmonary ventricle retraining causes upregulation of myocardial glucose 6-phosphate dehydrogenase activity. It may suggest that the undesirable "pathologic systolic overload" is influenced by activation of penthose pathway and cytosolic Nicotinamide adenine dinucleotide phosphate availability. This altered energy substrate metabolism can elevate levels of free radicals by Nicotinamide adenine dinucleotide phosphate oxidase, an important mechanism in the pathophysiology of heart failure.

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Sobrecarga sistólica intermitente promove melhor desempenho miocárdico em animais adultos

Abstract: Background: Corrected transposition of great arteries often evolves with right ventricular dysfunction. The ventricular preparation for anatomic correction in adult patients has produced disappointing results.

Cited by 15 publications

References 33 publications

The Echocardiography in the Cardiovascular Laboratory: A Guide to Research with Animals

The Echocardiography in the Cardiovascular Laboratory: A Guide to Research with Animals

Reversible pulmonary trunk banding: Myocardial vascular endothelial growth factor expression in young goats submitted to ventricular retraining

Reversible pulmonary trunk banding. IX. G6PD activity of adult goat myocardium submitted to ventricular retraining

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