Sobrestimación de alergia alimentaria reportada por padres en un centro peruano de alergia, asma e inmunología

Mendoza-Quispe, Daniel; Alvarez, Liliana; Galván, César

doi:10.17843/rpmesp.2018.354.3763

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…[1][2][3] It is important to mention that overdiagnosis is also reported; for example, in Peru, 40.9% of parents reported FA in their children, as documented in a national reference center for allergic diseases. 4 Cow's milk protein allergy (CMPA) is the most frequently diagnosed FA among children younger than 1 year. However, precise data in developing countries remains elusive, as several studies rely on self-reports, often lacking comprehensive assessments including family history, clinical characteristics, relationship with food exposure, utilization of FA tests, or conducting a double-blinded placebo-control food challenge (DBPCFC).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, epidemiological data on FA in these regions is limited due to low public awareness, inadequate physician education and training, limited access to healthcare and diagnostic tools, shortage of allergists, and overlap with other conditions such as malnutrition and childhood illnesses 1–3 . It is important to mention that overdiagnosis is also reported; for example, in Peru, 40.9% of parents reported FA in their children, as documented in a national reference center for allergic diseases 4 …”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021–2022

Calle,

Díaz‐Vásquez,

Córdova‐Calderón

et al. 2024

Immunity Inflam & Disease

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BackgroundCow's milk protein allergy (CMPA) remains relatively understudied in Latin America.MethodsIn this observational study, we enrolled 64 patients with a median age of 3 months, of whom 60% were male. Patients included had a history of IgE‐mediated reactions with IgE sensitization or non‐IgE‐mediated reactions or symptoms following exposure to cow's milk. They underwent skin prick test, ImmunoCAP, fecal calprotectin (FC), and fecal eosinophil‐derived neurotoxin (EDN), in addition to double‐blinded placebo‐controlled oral food challenges (DBPCFC), with clinical evolution and tolerance acquisition observed over 1 year.ResultsMalnutrition was present in 78.1% of patients, and 87.5% had a family history of atopy, with 51.6% receiving exclusive breastfeeding. Gastrointestinal manifestations were prevalent in 90.6% of patients, followed by dermatological manifestations (10.9%), with only 2 experiencing anaphylaxis. IgE‐mediated CMPA was observed in only six patients. In those with non‐IgE‐mediated CMPA, FC had a median of 284 mg/dL (IQR: 138.5–415.5), while EDN had a median of 508.5 mg/dL (IQR: 160.25–868). One year after diagnosis, median FC significantly decreased (p < 0.0001), and malnutrition prevalence reduced to 17.1%. Moreover, 81% of patients acquired tolerance following DBPCFC, with 52% utilizing nutritional replacement formulas at diagnosis. Notably, 94% of those extensively hydrolyzed casein‐based formulas achieved tolerance (p = 0.08).ConclusionOur findings provide a foundational framework for future investigations into CMPA diagnosis, tolerance acquisition, and the utilization of hypoallergenic formulas tailored to the unique characteristics of our region.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021–2022

Calle,

Díaz‐Vásquez,

Córdova‐Calderón

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

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“…Also, FA symptoms can overlap with those of malnutrition and other childhood illnesses, making proper diagnosis difficult, especially given the limited number of allergists in developing countries (1)(2)(3). These difficulties can also be reflected in FA overdiagnosis, as demonstrated by a study carried out by Mendoza D. et al (4) in Peru, in which 40.9% of patients whose parents reported some type of FA in a national reference center of allergic diseases. Cow's milk protein allergy (CMPA) is the FA most frequently found in children under 1 year of age.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics, laboratory tests and tolerance acquisition in infants less than one year of age with cow's milk protein allergy in a private center in Lima -- Peru for the period 2021 -2022

Galván-Calle,

Vasquez,

Córdova-Calderón

et al. 2024

Preprint

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Cow’s milk protein allergy (CMPA) in Latin America is little studied. We conducted a prospective study in 64 patients with a median age of 3 months, 39/64 (60.94%) were male, 23/64 (35.93%) had malnutrition, 56/64 (87.5%) had familiar atopy, 34/64 (51.56%) were receiving exclusive breastfeeding (EBF). The patients passed a medical evaluation by the specialist and underwent: Prick Test, ImmunoCAP, Fecal Calprotectin (FC) and fecal eosinophil derived neurotoxin (EDN), double-blind placebo control oral food challenges (DBPCFC) and were observed for one year regarding their clinical evolution and acquisition of tolerance. 58/64 (90.63%) had gastrointestinal manifestations, 7/64 (10.94%) had a dermatological manifestation, 2/64 (3.1%) had respiratory manifestations and 2/64 (3.1%) had anaphylaxis. 6/64 (9.38%) had an IgE - mediated CMPA. In patients with Non - IgE Mediated CMPA, fecal calprotectin was found to have a median of 284 mg/dL and an interquartile range (IQR) of 138.5 - 415.5. EDN had a median of 508.5 mg/dL with an IQR of 160.25 - 868. One year after diagnosis, the median FC decreased significantly with p < 0.0001. Malnutrition after one year was reduced to 17.18%. Likewise, 52/64 (81%) acquired tolerance after practicing DBPCFC on them. 33/64 (52%) used nutritional replacement formulas from the time of diagnosis, those who used Nutramigen LGG 15/16 (94%) acquired tolerance after practicing DBPCFC while 12/17 (71%) of those who used other formulas acquired tolerance (p. 0.08). Our findings are a good starting point for future studies that explore the diagnosis, acquisition of CMPA tolerance, and the use of hypoallergenic formulas with the particularities of our region.

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Food allergy across the globe

Sampath

Abrams

Adlou

et al. 2021

Journal of Allergy and Clinical Immunology

183

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Sobrestimación de alergia alimentaria reportada por padres en un centro peruano de alergia, asma e inmunología

Cited by 5 publications

References 4 publications

Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021–2022

Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021–2022

Clinical characteristics, laboratory tests and tolerance acquisition in infants less than one year of age with cow's milk protein allergy in a private center in Lima -- Peru for the period 2021 -2022

Food allergy across the globe

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