Social Activity and Healthy Aging: A Study of Aging Danish Twins

Christensen, Kaare

doi:10.1375/twin.10.2.255

Cited by 87 publications

(78 citation statements)

References 37 publications

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“…The study samples were drawn from two surveys conducted at the Danish Twin Registry (Skytthe et al, 2013) for which data on DNA methylation were already available: the Longitudinal Study of Aging Danish Twins (LSADT) (McGue & Christensen, 2007) and a study of the Extremely Birth Weight Discordant Twins (Frost et al, 2012).…”

Section: Experimental Procedures Study Samplesmentioning

confidence: 99%

“…The study was initiated in 1995 and surviving twins were followed-up every second year through 2007 (Christensen et al, 1999;McGue & Christensen, 2007). In 1997 and 2007, whole blood samples were collected from same-sex twin pairs, and the samples included in the present study consisted of those 18 monozygotic (MZ) pairs and 25 dizygotic (DZ) pairs, which participated in both the 1997 and the 2007 wave.…”

Section: Experimental Procedures Study Samplesmentioning

confidence: 99%

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DNA methylation age is associated with mortality in a longitudinal Danish twin study

et al. 2015

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SummaryAn epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment of health and mortality. In this study, we estimated the DNAm age of 378 Danish twins, age 30-82 years, and furthermore included a 10-year longitudinal study of the 86 oldest-old twins (mean age of 86.1 at follow-up), which subsequently were followed for mortality for 8 years. We found that the DNAm age is highly correlated with chronological age across all age groups (r = 0.97), but that the rate of change of DNAm age decreases with age. The results may in part be explained by selective mortality of those with a high DNAm age. This hypothesis was supported by a classical survival analysis showing a 35% (4-77%) increased mortality risk for each 5-year increase in the DNAm age vs. chronological age. Furthermore, the intrapair twin analysis revealed a more-than-double mortality risk for the DNAm oldest twin compared to the co-twin and a 'doseresponse pattern' with the odds of dying first increasing 3.2 (1.05-10.1) times per 5-year DNAm age difference within twin pairs, thus showing a stronger association of DNAm age with mortality in the oldest-old when controlling for familial factors. In conclusion, our results support that DNAm age qualifies as a biomarker of aging.

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Section: Experimental Procedures Study Samplesmentioning

confidence: 99%

Section: Experimental Procedures Study Samplesmentioning

confidence: 99%

DNA methylation age is associated with mortality in a longitudinal Danish twin study

et al. 2015

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“…Each survey of the LSADT and the 1905 Cohort Study comprises multidimensional face-to-face interviews focusing on health and lifestyle issues, as well as objective assessments of cognitive and physical abilities. [9][10][11] The Danish Centenarian Study is a nationwide epidemiological survey of all persons living in Denmark who celebrated their 100th birthday during a 14-month period from 1995 to 1996. A year and a half later, 21 participants were still alive and were revisited.…”

Section: Study Populationmentioning

confidence: 99%

Skewed X inactivation and survival: a 13-year follow-up study of elderly twins and singletons

Mengel‐From

Thinggaard²,

Christiansen³

et al. 2011

Eur J Hum Genet

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In mammalian females, one of the two X chromosomes is inactivated in early embryonic life. Females are therefore mosaics for two cell populations, one with the maternal and one with the paternal X as the active X chromosome. A skewed X inactivation is a marked deviation from a 50:50 ratio. In populations of women past 55-60 years of age, an increased degree of skewing (DS) is found. Here the association between age-related skewing and mortality is analyzed in a 13-year follow-up study of 500 women from three cohorts (73-100 years of age at intake). Women with low DS had significantly higher mortality than the majority of women who had a more skewed DS (hazard ratio: 1.30; 95% CI: 1.04-1.64). The association between X inactivation and mortality was replicated in dizygotic twin pairs for which the co-twin with the lowest DS also had a statistically significant tendency to die first in the twin pairs with the highest intra-pair differences in DS (proportion: 0.71; 95% CI: 0.52-0.86). Both results suggest that lower DS is associated with higher mortality. We therefore propose that age-related skewing may be partly due to a population selection with lower mortality among those with higher DS. European Journal of Human Genetics (2012) 20, 361-364; doi:10.1038/ejhg.2011.215; published online 7 December 2011Keywords: aging; sex; mortality INTRODUCTIONThe biological phenomenon of X-chromosome inactivation is observed in females across a variety of mammalian species. Females have two X chromosomes, of which either the maternal or the paternal X is inactivated in early embryonic life, at about the time of implantation. 1 Females are therefore mosaics for two cell populations, one with the maternal and one with the paternal X as the active X chromosome. Early in life the two cell populations are normally distributed around a 50:50 ratio. 2,3 In some females, one of the two cell populations is more abundant than the other and the value of the larger proportion is called the degree of skewing (DS), with DSZ50. DS¼50 is therefore a complete random X inactivation and DS¼100 is a completely skewed X inactivation. X inactivation is believed to occur randomly for each cell and to be permanent for all descendants of the cell. For women younger than 55-60 years of age, DS does not increase significantly with age in populations 2,3 or within the same individual. 4 However, DS increases considerably with age in cross-sectional studies of populations older than 55-60 years and this age association continues to increase in populations at the most advanced ages. 2,3,5 Most X-inactivation studies have been performed on peripheral blood cells, but a higher frequency of skewed X inactivation in elderly women has also been found in buccal swab cells. 6,7 Most X-inactivation studies use an indirect assay targeted to a methylation site and polymorphic sequence named the HUMARA assay. The representativeness of this indirect method for studying X inactivation has been questioned. Recently, however, skewing of X inactivation in aging women was co...

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“…Analogously, Brown et al (2016), using data from the Victoria Longitudinal Study, found that the engagement in social activities for older adults was related to participation in everyday cognitive activities and in turn to better cognitive performance. Conversely, lack of association between social activity and cognitive functioning along time was found in other studies (McGue and Christensen, 2007;Aartsen et al 2002;Green et al 2008), which used a global measure of cognitive functioning and a variety of specific cognitive tasks.…”

Section: Introductionmentioning

confidence: 63%

Social networks and social activities promote cognitive functioning in both concurrent and prospective time: evidence from the SHARE survey

2018

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Social Activity and Healthy Aging: A Study of Aging Danish Twins

Cited by 87 publications

References 37 publications

DNA methylation age is associated with mortality in a longitudinal Danish twin study

DNA methylation age is associated with mortality in a longitudinal Danish twin study

Skewed X inactivation and survival: a 13-year follow-up study of elderly twins and singletons

Social networks and social activities promote cognitive functioning in both concurrent and prospective time: evidence from the SHARE survey

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