Social and behavioral determinants of attitudes towards and practices of hepatitis B vaccine birth dose in Vietnam

Le, Xuan Thanh Thi; Ishizumi, Atsuyoshi; Nguyen, Huong Thi Thu; Duong, Hong Thi; Dang, Huyen; Manh, Cuong; Trung, Phạm Quang; Le, Huong Thi; Iijima, Makiko; Tohme, Rania A.; Patel, Palak; Abad, Neetu

doi:10.1016/j.vaccine.2020.11.009

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…The average proportion of parental refusal in our study was as high as 67.5% among all cases of missed timely HepB-BD. Data from all over the world suggest that the main reasons for low HepB-BD coverage are parental concerns on vaccination safety and a lack of information [31][32][33]. To find out if this is true in the settings of this study, we conducted a survey of the university students and teachers, from both medical and non-medical specialties, aimed to characterize their attitudes to vaccines and vaccination, including vaccination against hepatitis B.…”

Section: Discussionmentioning

confidence: 99%

Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity

et al. 2021

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Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population. Here, we assessed the timely coverage of newborns with the birth dose (HepB-BD), second dose (HepB-2nd), and three vaccine doses (HepB3) in two remote regions of Russia with low (Belgorod Oblast) and high (Yakutia) levels of hepatitis B virus (HBV) endemicity. Vaccination data were obtained from the medical records of 1000 children in Yakutia and 2182 children in Belgorod Oblast. Sera of healthy volunteers from Belgorod Oblast (n = 1754) and Yakutia (n = 1072) across all age groups were tested for serological markers of HBV to assess the infection prevalence and herd immunity. Average HepB-BD coverage was 99.2% in Yakutia and 89.4% in Belgorod Oblast (p < 0.0001) and in both regions varied significantly, from 66% to 100%, between medical centers. The principal reason for the absence of HepB-BD was parent refusal, which accounted for 63.5% of cases of non-vaccination (83/123). While timely HepB-2nd coverage was only 55.4%–64.7%: HepB3 coverage by the age of one year exceeded 90% in both study regions. HBV surface antigen (HBsAg) prevalence in the 1998–2019 birth cohort was 0.2% (95% CI: 0.01–1.3%) in Belgorod Oblast and 3.2% (95% CI: 1.9–5.2%) in Yakutia. The proportion of persons testing negative for both antibodies to HBsAg (anti-HBs) and antibodies to HBV core antigen (anti-HBc) in the 1998–2019 birth cohort was 26.2% (125/481) in Belgorod Oblast and 32.3% (162/501) in Yakutia. We also assessed the knowledge of and attitude towards vaccination among 782 students and teachers of both medical and non-medical specialties from Belgorod State University. Only 60% of medical students knew that hepatitis B is a vaccine-preventable disease. Both medical and nonmedical students, 37.8% and 31.3%, respectively, expressed concerns about safety and actual necessity of vaccination. These data indicate the need to introduce a vaccine delivery audit system, improve medical education with respect to vaccination strategies and policies, and reinforce public knowledge on the benefits of vaccination.

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Section: Discussionmentioning

confidence: 99%

Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity

et al. 2021

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“…Timely BD vaccination depends on training of healthcare workers who are present at the time of birth, requiring task-shifting to involve different personnel from those who deliver the routine paediatric immunisation schedule, and outreach into communities which specifically considers risks associated with home-births, rural communities, and season of birth. 135 , 136 Financial incentives or subsidies could be provided to healthcare systems to boost coverage, while relaxation of strict cold chain requirements would support monovalent vaccine distribution in settings in which many births occur outside a healthcare setting.…”

Section: Delivery Of Enhanced Pmtct Interventionsmentioning

confidence: 99%

“…community health extension workers). 136 , 142 , 143 Informing the population and healthcare workers creates demand for interventions, and provides crucial community engagement and advocacy. 144 There is typically a high level of acceptance of PMTCT interventions by women during pregnancy and post-partum, 145 , 146 and this population can be strong advocates for themselves and their infants.…”

Section: Delivery Of Enhanced Pmtct Interventionsmentioning

confidence: 99%

Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus

Matthews¹,

Ocama²,

Wang³

et al. 2023

JHEP Reports

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“…In adults, a large proportion of HBV infections occur through sexual relations [4,5]. Several studies have focused on the social determinants associated with hepatitis B vaccination [6,7], and on ways to limit mother-to-child transmission [8,9]. Many other studies have investigated the implementation of screening programs, especially those related to public health policy [2,10].…”

Section: Prevention Of Hepatitis B Infection: Access To Screeningmentioning

confidence: 99%

Contribution of HIV/AIDS-Related Human and Social Sciences Research to a Better Understanding of the Challenges of Hepatitis B Prevention, Diagnosis and Care

Bauquier

Préau

2021

Microorganisms

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Recent scientific advances in hepatitis B virus research hint at the possibility of finding a cure in the medium term. In this context, the characterization of infected persons constitutes a major public health issue in terms of implementing adapted screening and prevention strategies. Overcoming the current challenges national health systems face in hepatitis B diagnosis is essential if the World Health Organization’s target of treating 80% of infected patients by 2030 is to be reached. These challenges reflect those previously faced in the fight against HIV/AIDS. Using the knowledge produced to date in Human and Social Sciences research in the fight against HIV/AIDS, we propose avenues of reflection to support and guide the development of research in the diagnosis of hepatitis B infection. More specifically, we present theoretical, methodological and epistemological considerations for how HSS research can be optimized in the following three HBV diagnosis-related areas: (i) access to screening; (ii) retention in care; and (iii) the integration of quality of life measurement in clinical trials.

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Social and behavioral determinants of attitudes towards and practices of hepatitis B vaccine birth dose in Vietnam

Cited by 7 publications

References 39 publications

Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity

Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity

Enhancing interventions for prevention of mother-to-child- transmission of hepatitis B virus

Contribution of HIV/AIDS-Related Human and Social Sciences Research to a Better Understanding of the Challenges of Hepatitis B Prevention, Diagnosis and Care

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