Social anxiety is associated with BNST response to unpredictability

Clauss, Jacqueline A.; Avery, Suzanne N.; Benningfield, Margaret M.; Blackford, Jennifer Urbano

doi:10.1002/da.22891

Cited by 76 publications

(56 citation statements)

References 57 publications

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“…In our previous study using the movingcircles paradigm (where stressor delivery was uncontrollable), we also detected a parametric effect of threat proximity on BST responses; thus, as the circles approached each other activity increased (Meyer, Padmala et al 2019). This latter study is part of a growing literature in humans that has steadily improved imaging parameters and procedures to image this technically challenging region (e.g., Clauss, Avery et al 2019, Torrisi, Alvarez et al 2019, Hur, Smith et al 2020).…”

Section: Discussionsupporting

confidence: 59%

Controllability over stressor decreases responses in key threat-related brain areas

Limbachia

Morrow

Khibovska

et al. 2020

Preprint

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Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on the responses to stressors themselves is poorly understood. Using functional magnetic resonance imaging, we investigated how controllability altered responses to a shock-plus-sound stressor. Using a between-group yoked design, participants in controlled and uncontrolled groups experienced the same amount of stressor exposure. Employing both Bayesian multilevel analysis targeting regions of interest and standard voxelwise analysis, we found that controllability decreased stressor-related responses across key threat-related regions, notably in the bed nucleus of the stria terminalis (part of the extended amygdala) and the anterior insula. The posterior cingulate cortex, the posterior insula, and possibly the medial frontal gyrus (in exploratory analyses) were uncovered as sites where control over the stressor increased brain responses. Our findings support the idea that the aversiveness of the stressor is reduced when controllable, leading to decreased responses across key regions involved in anxiety-related processing, even at the level of the extended amygdala.

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Section: Discussionsupporting

confidence: 59%

Controllability over stressor decreases responses in key threat-related brain areas

Limbachia

Morrow

Khibovska

et al. 2020

Preprint

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“…Regressors were convolved with a canonical double‐gamma hemodynamic response function; furthermore, their temporal derivatives were included. We investigated the habituation by using the contrast “first half > last half” and applied a hypothesis‐driven region‐of‐interest (ROI) approach focusing on the regions described by Avery & Blackford (), being the amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), orbitofrontal cortex, fusiform face area (FFA), primary visual cortex (V1), and extrastriate visual cortex; we added the bed nucleus of stria terminalis (BNST) given its role in anxiety (Avery, Clauss, & Blackford, ; Clauss, Avery, Benningfield, & Blackford, ; Figel et al, ). Specifics on these ROIs are available in the Supporting Information Online.…”

Section: Methodsmentioning

confidence: 99%

“…we added the bed nucleus of stria terminalis (BNST) given its role in anxiety Clauss, Avery, Benningfield, & Blackford, 2019;Figel et al, 2019). Specifics on F I G U R E 1 Failure to habituate within families genetically enriched for social anxiety disorder.…”

Section: Fmri Data: Habituation Responsementioning

confidence: 99%

Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder

et al. 2019

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BackgroundSocial anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we examined whether impaired habituation to neutral faces is a putative neurobiological endophenotype of SAD by using data from the multiplex and multigenerational Leiden Family Lab study on SAD.MethodsParticipants (n = 110; age, 9.2 – 61.5 years) performed a habituation paradigm involving neutral faces, as these are strong social stimuli with an ambiguous meaning. We used functional magnetic resonance imaging data to investigate whether brain activation related to habituation was associated with the level of social anxiety within the families. Furthermore, the heritability of the neural habituation response was estimated.ResultsOur data revealed a relationship between impaired habituation to neutral faces and social anxiety in the right hippocampus and right amygdala. In addition, our data indicated that this habituation response displayed moderate ‐ to‐moderately high heritability in the right hippocampus.ConclusionThe present results provide support for altered habituation as a candidate SAD endophenotype; impaired neural habitation cosegregrated with the disorder within families and was heritable. These findings shed light on the genetic susceptibility to SAD.

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“…Anxiety is a common and chronic psychiatric disorder that is a source of suffering and impairment [96]. In 2017, the World Health Organization reported that more than 260 million people suffer from an anxiety disorder [97].…”

Section: Anxietymentioning

confidence: 99%

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

Fernández-Demeneghi¹,

Isidro²,

Acosta-Mesa³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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This chapter is based in the compilation and analysis of different in vitro, preclinical, and clinical studies, which explored the potential beneficial bioactivity of supplementation with berries on some alterations in the central nervous system (CNS). The last section of the chapter describes the possible mechanisms of action of polyphenols, anthocyanins, and other compounds present in berries as well as their relationship with anxiety, depression, and Alzheimer's (AD) and Parkinson's diseases (PD) and their implication in the prevention of cognitive decline and senescence motor functions. Electronic databases as Springer, PubMed, Scopus, and Elsevier were used. Papers were selected by topic specially those related with berries, year of publication, and authors. The present chapter evidenced the potential health effect as neuroprotector of different berries and their bioactive compounds mainly flavonoids, polyphenols, and anthocyanins, on diseases such as anxiety, depression, and Alzheimer's and Parkinson's diseases. In conclusion, for human nutrition berry fruit supplementation might be an excellent source of antioxidant and alternative for prevention and reduction of symptoms in diseases such as anxiety, depression, Alzheimer's, and Parkinson's.

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Social anxiety is associated with BNST response to unpredictability

Cited by 76 publications

References 57 publications

Controllability over stressor decreases responses in key threat-related brain areas

Controllability over stressor decreases responses in key threat-related brain areas

Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

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