Social attainment in survivors of pediatric central nervous system tumors: a systematic review and meta-analysis from the Children’s Oncology Group

Schulte, Fiona; Kunin‐Batson, Alicia; Olson‐Bullis, Barbara A.; Banerjee, Pia; Hocking, Matthew C.; Janzen, Laura; Kahalley, Lisa S.; Wroot, Hayley; Forbes, Caitlin; Krull, Kevin R.

doi:10.1007/s11764-019-00808-3

Cited by 61 publications

(63 citation statements)

References 59 publications

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“…The nervous system is classified into the central nervous system (CNS) containing brain and spinal cord and the peripheral nervous system (PNS) created by the nerves leaving the CNS ( Figure 2). The PNS somatic system transmits sensory and motor information for the CNS, while the autonomic one controls automatic functions (e.g., heart beating, blood pressure) [60][61][62]. The basic functional units in the nervous system having specific electrical properties are neurons and neuroglia (Figure 3), which enable effective transmission of the signals [63,64].…”

Section: Mechanotransduction and Piezoelectricity In Living Organismsmentioning

confidence: 99%

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

2020

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Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities, which still lacks an effective treatment. Tissue engineering in the post-injury brain represents a promising option for cellular replacement and rescue, providing a cell scaffold for either transplanted or resident cells. Tissue engineering relies on scaffolds for supporting cell differentiation and growth with recent emphasis on stimuli responsive scaffolds, sometimes called smart scaffolds. One of the representatives of this material group is piezoelectric scaffolds, being able to generate electrical charges under mechanical stimulation, which creates a real prospect for using such scaffolds in non-invasive therapy of neural tissue. This paper summarizes the recent knowledge on piezoelectric materials used for tissue engineering, especially neural tissue engineering. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges, and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and serves as a starting point for novel research pathways in the most relevant and challenging open questions.

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Section: Mechanotransduction and Piezoelectricity In Living Organismsmentioning

confidence: 99%

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

2020

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“…The lack of association between diagnostic category-or other medical/demographic variables-and social functioning profiles was surprising, especially considering the vast extant literature indicating that survivors of brain tumors tend to struggle with social functioning. [3][4][5][6] However, there is also evidence that survivors of brain tumors may minimize problems with their functioning on self-report measures. 40 As such, given that our primary outcome measure was selfreport, there may be more social concerns in the brain tumor group than is reflected by our findings.…”

Section: Differences In Functioning By Social Functioning Profilesmentioning

confidence: 99%

“…research has documented social skill deficits (eg, poor affect recognition), social isolation (eg, few friends), and reduced achievement of social milestones (eg, romantic relationships, living independently). [3][4][5][6] Comparative research has demonstrated that the social functioning deficits of survivors of brain tumors are different than those of other childhood cancers. 7 However, there are indications that survivors of non-CNS cancers are not immune to social difficulties, with research documenting self-and parent-reported social functioning concerns in a significant minority.…”

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confidence: 99%

Profiles of perceived social functioning in adolescent and young adult survivors of childhood cancer

et al. 2020

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Objectives: Social interaction and peer relationships are critical for development, especially for adolescents and young adults (AYA). Cancer treatment may disrupt social functioning and impact quality of life. Prior research into AYA social functioning has primarily been qualitative in nature or assessed via broad measures of functioning. Given the multi-dimensional nature of social functioning, and its importance for AYA, a person-centered approach to analyses is needed. Methods: AYA survivors of childhood cancer, ages 13 to 23 (n = 192, 51% male) and at least 1 year post-treatment (M = 7.35 ± 4.18 years post), completed measures to assess perceived social functioning, social support, and positive and negative affect. Caregivers also completed a measure of social functioning. Latent profile analysis was used to empirically derive profiles of perceived social functioning using the selfperception profile for adolescents (SPPA). Results: A 3-class solution provided the best fit to the data: 58.9% average, 33.7% high, and 7.5% low functioning. The average group reported mean scores that were similar to normative values available in the SPPA manual. Demographic and medical factors were unrelated to class membership. Social support and positive/negative affect differed significantly by class; caregiver-report of social functioning did not. Conclusions: Overall, the majority of AYA survivors of childhood cancer are doing well socially, with perceived adequate social functioning associated with both high levels of social support as well as greater perceptions of positive affect. Future work is needed to elucidate longitudinal trajectories of social functioning, as well as to identify and intervene with those survivors who are struggling. K E Y W O R D S adolescent and young adulthood, cancer, childhood cancer, latent profile analysis, oncology, social functioning, survivorship Social interaction and peer relationships are a critical part of human development. However, the diagnosis and treatment of cancer can disrupt this process and lead to social isolation and distress, ultimately affecting quality of life. 1 This may be particularly true for adolescents and young adults (AYA), for whom the peer group is critically important to psychological functioning, emerging independence and sense of self. Indeed, the Standards for Psychosocial Care for Children with Cancer and Their Families highlights the essential importance of peer interaction during and after cancer treatment, particularly for AYA. 2 Historically, most social functioning research has focused on survivors of pediatric brain tumors, given their neurocognitive deficits and associated social interaction weaknesses. 3 A large body of

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“…Compared to their siblings, survivors of pediatric brain tumors have a 45 fold increased risk of hearing impairment, 8 fold increased risk of visual impairment, and an 11 fold increased risk of unemployment (Gupta and Jalali, 2017). Survivors are also less likely to complete secondary education, live independently, or be married (Schulte et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Deficits and Altered Functional Brain Network Organization in Pediatric Brain Tumor Patients

Anandarajah

Seitzman

McMichael

et al. 2020

Preprint

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These authors contributed equally to this work Affiliations:Abstract Pediatric brain tumor survivors experience significant cognitive sequelae from their diagnosis and treatment. The exact mechanisms of these injuries are poorly understood, and validated predictors of cognitive outcome are lacking. The current study aims to determine if there are abnormalities in functional brain network organization and cognitive performance in pediatric brain tumor patients, measured via resting state functional magnetic resonance imaging (rsfMRI) and the NIH Toolbox Cognition Battery, respectively. Further, we assess potential relationships between changes in brain network architecture and behavior in the patients.Patients ages 4-18 years old with diagnosis of a brain tumor underwent awake rsfMRI during regularly scheduled clinical imaging and were tested with the NIH Toolbox Cognition Battery. Overall, functional brain network organization was significantly different in patients compared to age-and sex-matched healthy controls (p < 0.001).Network integrity within the dorsal attention network was particularly affected, with 86% of patients having connectivity strength 2+ SD below the mean of controls (p < 0.0001).Moreover, cognitive testing of patients demonstrated significant impairments in multiple domains, including attention (p < 0.05, FDR corrected). Finally, a significant amount of variance of age-adjusted total composite scores from the Toolbox was explained by changes in segregation between the dorsal attention and default mode networks as well as sex (R 2 = 0.52, p < 0.05). Pediatric brain tumor patients demonstrated statistically significant deficits in multiple cognitive domains and multiple abnormalities in brain network architecture.Thus, rsfMRI may provide insight into neural systems that underlie these changes in cognitive function, suggesting that these metrics may serve as a biomarker for cognitive performance.

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Social attainment in survivors of pediatric central nervous system tumors: a systematic review and meta-analysis from the Children’s Oncology Group

Cited by 61 publications

References 59 publications

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

Profiles of perceived social functioning in adolescent and young adult survivors of childhood cancer

Cognitive Deficits and Altered Functional Brain Network Organization in Pediatric Brain Tumor Patients

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