Social behavior impairment in offspring exposed to maternal seizures in utero

Novaes, Gisane Faria; Amado, Débora; Cysneiros, Roberta Monterazzo

doi:10.1007/s00702-011-0751-1

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…The social behavior apparatus was adapted by Novaes et al (2012) from Crawley (2007). The apparatus was an acrylic rectangular box divided into three compartments of equal size (39 cm height × 26 cm width × 41 cm deep) by retractable doors.…”

Section: Methodsmentioning

confidence: 99%

Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures

Castelhano¹,

Cassane²,

Scorza³

et al. 2013

Front. Behav. Neurosci.

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Neonatal seizures are the most common manifestation of neurological dysfunction in the neonate. The prognosis of neonatal seizures is highly variable, and the controversy remains whether the severity, duration, or frequency of seizures may contribute to brain damage independently of its etiology. Animal data indicates that seizures during development are associated with a high probability of long-term adverse effects such as learning and memory impairment, behavioral changes and even epilepsy, which is strongly age dependent, as well as the severity, duration, and frequency of seizures. In preliminary studies, we demonstrated that adolescent male rats exposed to one-single neonatal status epilepticus (SE) episode showed social behavior impairment, and we proposed the model as relevant for studies of developmental disorders. Based on these facts, the goal of this study was to verify the existence of a persistent deficit and if the anxiety-related behavior could be associated with that impairment. To do so, male Wistar rats at 9 days postnatal were submitted to a single episode of SE by pilocarpine injection (380 mg/kg, i.p.) and control animals received saline (0.9%, 0.1 mL/10 g). It was possible to demonstrate that in adulthood, animals exposed to neonatal SE displayed low preference for social novelty, anxiety-related behavior, and increased stereotyped behavior in anxiogenic environment with no locomotor activity changes. On the balance, these data suggests that neonatal SE in rodents leads to altered anxiety-related and abnormal social behaviors.

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Section: Methodsmentioning

confidence: 99%

Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures

Castelhano¹,

Cassane²,

Scorza³

et al. 2013

Front. Behav. Neurosci.

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“…The main principle of this test is based on the free choice of the animal in exploring a new object and a new juvenile animal. The social behavior apparatus was adapted from previous studies [40,41]. The device used was a rectangular acrylic box (100 × 100 cm).…”

Section: Social Preferencementioning

confidence: 99%

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

Castro

Medeiros

Guarnieri

et al. 2017

Epilepsy & Behavior

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Accumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".

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“…The placentas from the epileptic rat models had areas of ischaemic infarction. More recently, rats exposed to seizures in utero showed impaired social behaviour compared with rats with no intrauterine exposure to seizures [13].…”

Section: Impact Of Generalized Seizuresmentioning

confidence: 99%

The impact of seizures on pregnancy and delivery

Sveberg

Svalheim

Taubøll

2015

Seizure

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Seizures before pregnancy are a predictor for seizures during pregnancy, and catamenial epilepsy may also predict the course of seizures during pregnancy. A first epileptic seizure may also have implications for the pregnancy, depending on the seizure aetiology. Seizures affecting maternal awareness and responsiveness may have cardiac effects on the foetus and may impact on the weight of the newborn. Status epilepticus in pregnancy is rare, but isolated cases of perinatal death and malformations after status epilepticus have been reported in women on antiepileptic drugs. Seizures during delivery occur in about 2% of pregnancies of women with epilepsy, and case studies indicate that the foetal heart may be affected. However, a diagnosis of epilepsy is not an indication per se for caesarean delivery. A well-planned pregnancy can reduce the likelihood of seizures occurring.

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Social behavior impairment in offspring exposed to maternal seizures in utero

Cited by 12 publications

References 26 publications

Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures

Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

The impact of seizures on pregnancy and delivery

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