Social cognition and neurocognition as independent domains in psychosis

Hooren, Susan van; Versmissen, Dagmar; Janssen, I.; Myin-Germeys, Inez; Campo, Joost à; Mengelers, Ron; Os, Jim van; Krabbendam, Lydia

doi:10.1016/j.schres.2008.02.022

Cited by 165 publications

(98 citation statements)

References 52 publications

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“…Social cognition in general is a complex construct that involves several low-and highlevel processes and multiple interacting structures (Adolphs, 2001, van Hooren et al, 2008. Our findings suggest that sense of agency and mentalizing represent two non-overlapping subdomains which independently contribute to the multifaceted construct of social cognition in schizophrenia.…”

Section: Resultsmentioning

confidence: 77%

“…However, only few studies have directly investigated the relation between these two socialcognitive processes. Van Hooren et al (2008), in a factor analysis, found no overlap between these processes among other social-cognitive processes. David et al (2006) investigated self-other distinction and mentalizing in a functional imaging study, but found no interaction of the two processes on a neural level.…”

Section: The Relationship Between Mentalizing and Sense Of Agency In mentioning

confidence: 85%

“…Van Hooren et al (2008) investigated the association between a range of social-cognitive processes, finding a lack of overlap between a sense of agency and mentalizing, and more broadly, between all the social-cognitive processes investigated. More specifically, David et al (2008) assessed the two processes in individuals with high-functioning autism and Asperger's Syndrome (HFA/ AS), which is characterized by prominent deficits in social cognition and interaction.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in self-rating questionnaires, schizophrenia patients indicate lower levels of perspective taking compared to controls, but higher levels of personal distress when confronted with emotions of other people (Shamay-Tsoory et al, 2007, Fujiwara et al, 2008, Derntl et al, 2009, Haker and Rössler, 2009 Although the self-other distinction seems fundamental to mentalizing, there is evidence suggesting that they represent two independent processes. Van Hooren et al (2008) investigated the association between a range of social-cognitive processes, finding a lack of overlap between a sense of agency and mentalizing, and more broadly, between all the social-cognitive processes investigated. More specifically, David et al (2008) assessed the two processes in individuals with high-functioning autism and Asperger's Syndrome (HFA/ AS), which is characterized by prominent deficits in social cognition and interaction.…”

mentioning

confidence: 99%

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Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

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The sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency and mentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self-or other-generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the mind in the eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated. Both sense of agency and mentalizing were impaired in schizophrenia patients compared to healthy controls. However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group. The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia, suggesting that the multifaceted construct of social cognition consists of independent subdomains in healthy and psychiatrically ill individuals. AbstractThe sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency andmentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self or other generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the Mind in the Eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated.Both sense of agency and mentalizing were impaired in schizophrenics compared to healthy controls.However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group.The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia,suggesting that the multifaceted construct of social cognition consists of independ...

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Section: Resultsmentioning

confidence: 77%

Section: The Relationship Between Mentalizing and Sense Of Agency In mentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

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“…Moreover, there has been a number of studies which indicate the distinctiveness of SC from neurocognition in schizophrenia (Buchanan et al, 2005;Allen, Strauss, Donohue, & van Kammen, 2007;Pinkham, Penn, Perkins, & Lieberman, 2003;Sergi et al, 2007;Van Hooren et al, 2008). To aid in our understanding of why this may be the case, Penn et.…”

Section: Schizophreniamentioning

confidence: 99%

190. Social Cognition in Early Schizophrenia: Exploratory Factor Analysis and Subcortical Biomarkers

Mike

Guimond²,

Chakravarty

et al. 2017

Biological Psychiatry

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Longitudinal Cognitive Changes in Young Individuals at Ultrahigh Risk for Psychosis

et al. 2018

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Key PointsQuestionDo baseline and longitudinal cognitive architecture discriminate healthy controls from subgroups of young individuals at risk for psychosis?FindingsThis multiple-group design study involving 384 healthy controls and 173 individuals at ultrahigh risk for psychosis found that baseline cognitive architecture differentiated healthy controls from converters and nonremitters. Remitters were found to recover their cognitive deficits over time, but nonremitters did not.MeaningCognitive deficits appear to identify the individuals most likely to develop psychosis and appear to reflect an underlying deterioration of a person’s clinical condition over time.

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Social cognition and neurocognition as independent domains in psychosis

Cited by 165 publications

References 52 publications

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

190. Social Cognition in Early Schizophrenia: Exploratory Factor Analysis and Subcortical Biomarkers

Longitudinal Cognitive Changes in Young Individuals at Ultrahigh Risk for Psychosis

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