Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia

Pu, Shenghong; Nakagome, Kazuyuki; Yamada, Takeshi; Itakura, Masashi; Yamanashi, Takehiko; Yamada, Sayaka; Masai, Mieko; Miura, Akihiko; Yamauchi, Takahira; Satake, Takahiro; Iwata, Masaaki; Nagata, Izumi; Roberts, David L.; Kaneko, Koichi

doi:10.1038/srep22500

Cited by 20 publications

(15 citation statements)

References 54 publications

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“…Recent studies have assessed the neurocognitive domains together with the social cognitive domains in clinical rating scales, reporting mixed results regarding their link to brain structure and function 30 31 33 34 35 . Critically, none of these studies investigated the relationship of these 2 cognitive dimensions with brain structure and function independently.…”

Section: Discussionmentioning

confidence: 99%

“…A very recent report has shown that ToM performance was significantly lower in patients with DLPFC damage than in their control group counterparts 47 . Thus, it seems reasonable to consider that DLPFC functioning is relevant to ToM performance, above and beyond its relevance to traditional working memory 30 .…”

Section: Discussionmentioning

confidence: 99%

“…(1) Relative to healthy subjects, patients with schizophrenia have detectable abnormalities in working memory-related PFC neural activity, as measured using multi-channel NIRS imaging. (2) This neural activity is related to cognitive ability, in particular ToM (see our previous study 30 ), and working memory or verbal memory, and verbal fluency cognitive domains, as the improvement in these subcomponents in BACS was associated with the increased hemodynamic response caused by cognitive remediation therapy in our previous study 31 . In the present study, we analysed regional activation associated with cognitive tasks in 3 frontal brain regions of interest (ROIs) defined by Takizawa et al .…”

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confidence: 84%

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Association of fronto-temporal function with cognitive ability in schizophrenia

Nakagome

Itakura

et al. 2017

Sci Rep

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Deficits in neuropsychological performance are common in schizophrenia, but their relationship with the fronto-temporal functional abnormalities associated with this condition remains unclear. We explored the relationship between neuropsychological performance as measured using the Brief Assessment of Cognition in Schizophrenia (BACS) and the Social Cognition Screening Questionnaire theory of mind (ToM) subscale and fronto-temporal function in 23 patients with schizophrenia and 23 age- and gender-matched healthy controls (HCs), using 52-channel near-infrared spectroscopy (NIRS). Regional hemodynamic changes were significantly smaller in the schizophrenia group than in the HCs group in the ventro-lateral prefrontal cortex and the anterior part of the temporal cortex (VLPFC/aTC) and dorso-lateral prefrontal cortex and frontopolar cortex (DLPFC/FPC) regions. To dissect the effect of variance in BACS cognitive domains from the relationship between ToM function and fronto-temporal function, we performed additional partial correlation analyses between ToM and NIRS data, using BACS composite score as a control variable. The correlation between ToM and NIRS data remained significant only in the DLPFC/FPC region. This finding is important to models of recovery, as it suggests that intervention programs focusing on enhancing fronto-temporal function may have a greater impact on social and occupational outcomes than traditional rehabilitation programs focusing on neuropsychological performance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 84%

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Association of fronto-temporal function with cognitive ability in schizophrenia

Nakagome

Itakura

et al. 2017

Sci Rep

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“…As we observed for problem-oriented coping, this goes in the direction of a reversal of physiological restingstate network patterns. Frontopolar and temporal pole are indeed positively correlated structures of the DMN, whose local and synchronized activity has been related to theory of mind (Carrington & Bailey, 2009) and the processing of social interactions (Pu et al, 2016), with a focus on social rejection (Lee et al, 2014). Both of these elements might play roles when one considers seeking support.…”

Section: Resting-state Brain Connectivity and Copingmentioning

confidence: 95%

Brain functional connectivity correlates of coping styles

Santarnecchi

Sprugnoli

Tatti

et al. 2018

Cogn Affect Behav Neurosci

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Coping abilities represent the individual set of mental and behavioral strategies adopted when facing stress or traumatic experiences. Coping styles related to avoidance have been linked to a disposition to develop psychiatric disorders such as PTSD, anxiety, and major depression, whereas problem-oriented coping skills have been positively correlated with well-being and high quality of life. Even though coping styles constitute an important determinant of resilience and can impact many aspects of everyday living, no study has investigated their brain functional connectivity underpinnings in humans. Here we analyzed both psychometric scores of coping and resting-state fMRI data from 102 healthy adult participants. Controlling for personality and problem-solving abilities, we identified significant links between the propensity to adopt different coping styles and the functional connectivity profiles of regions belonging to the default mode (DMN) and anterior salience (AS) networks-namely, the anterior cingulate cortex, left frontopolar cortex, and left angular gyrus. Also, a reduced negative correlation between AS and DMN nodes explained variability in one specific coping style, related to avoiding problems while focusing on the emotional component of the stressor at hand, instead of relying on cognitive resources. These results might be integrated with current neurophysiological models of resilience and individual responses to stress, in order to understand the propensity to develop clinical conditions (e.g., PTSD) and predict the outcomes of psychotherapeutic interventions.

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“…202 The lateral PFC HbO response in SZ patients was directly associated with theory-of-mind scores. 203…”

Section: N-back Taskmentioning

confidence: 99%

Application of functional near-infrared spectroscopy in the healthcare industry: A review

Hong

Yaqub

2019

J. Innov. Opt. Health Sci.

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Functional near-infrared spectroscopy (fNIRS), a growing neuroimaging modality, has been utilized over the past few decades to understand the neuronal behavior in the brain. The technique has been used to assess the brain hemodynamics of impaired cohorts as well as able-bodied. Neuroimaging is a critical technique for patients with impaired cognitive or motor behaviors. The portable nature of the fNIRS system is suitable for frequent monitoring of the patients who exhibit impaired brain activity. This study comprehensively reviews brain-impaired patients: The studies involving patient populations and the diseases discussed in more than 10 works are included. Eleven diseases examined in this paper include autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, depressive disorders, anxiety and panic disorder, schizophrenia, mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease, stroke, and traumatic brain injury. For each disease, the tasks used for examination, fNIRS variables, and significant findings on the impairment are discussed. The channel configurations and the regions of interest are also outlined. Detecting the occurrence of symptoms at an earlier stage is vital for better rehabilitation and faster recovery. This paper illustrates the usability of fNIRS for early detection of impairment and the usefulness in monitoring the rehabilitation process. Finally, the limitations of the current fNIRS systems (i.e., nonexistence of a standard method and the lack of well-established features for classification) and future research directions are discussed. The authors hope that the findings in this paper would lead to advanced breakthrough discoveries in the fNIRS field in the future.

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Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia

Cited by 20 publications

References 54 publications

Association of fronto-temporal function with cognitive ability in schizophrenia

Association of fronto-temporal function with cognitive ability in schizophrenia

Brain functional connectivity correlates of coping styles

Application of functional near-infrared spectroscopy in the healthcare industry: A review

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