Social cognitive training in adolescents with chromosome 22q11.2 deletion syndrome: feasibility and preliminary effects of the intervention

Shashi, Vandana; Harrell, Waverly; Eack, Shaun M.; Sanders, C.; McConkie‐Rosell, Allyn; Keshavan, Matcheri S.; Bonner, Melanie J.; Schoch, Kelly; Hooper, Stephen R.

doi:10.1111/jir.12192

Cited by 41 publications

(27 citation statements)

References 44 publications

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“…Intervention models for targeted psychosocial training in 22q11.2DS have already been proposed [79, 80] and cognitive enhancement therapy of tailored exercises, which include perspective taking and identification of non-verbal social clues, has been shown to improve social cognitive abilities in adolescents with 22q11.2DS [80]. Also, the training scheme applied by Glaser et al [79] which targets focusing on the eyes, emotion recognition and understanding, and working memory has shown short-term improvements in these functions.…”

Section: Discussionmentioning

confidence: 99%

Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

Vangkilde

Jepsen

Schmock

et al. 2016

J Neurodevelop Disord

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BackgroundIdentification of the early signs of schizophrenia would be a major achievement for the early intervention and prevention strategies in psychiatry. Social impairments are defining features of schizophrenia. Impairments of individual layers of social competencies are frequently described in individuals with 22q11.2 deletion syndrome (22q11.2DS), who have high risk of schizophrenia. It is unclear whether and to what extent social impairments associate with subclinical negative and positive symptoms in 22q11.2DS, and which layer of social impairments are more correlated with schizophrenia-related symptoms. The aims of this study were to conduct a comprehensive investigation of social impairments at three different levels (function, skill, and cognition) and their interrelationship and to determine to what degree the social impairments correlate to subclinical levels of negative and positive symptoms, respectively, in a young cohort of 22q11.2DS not diagnosed with schizophrenia.MethodsThe level of social impairment was addressed using questionnaires and objective measures of social functioning (The Adaptive Behavior Assessment System), skills (Social Responsiveness Scale), and cognition (The Awareness of Social Inference Test and CANTAB Emotional Recognition Task), and the presence of subclinical symptoms of schizophrenia were evaluated using the Structured Interview for Prodromal Syndromes in a cross-sectional case-control study of 29 cases and 29 controls, aged 12 to 25 years. Association between social impairment and negative and positive symptoms levels was examined in cases only.ResultsSubjects with 22q11.2DS were highly impaired in social function, social skills, and social cognition (p ≤ 6.2 × 10−9) relative to control peers and presented with more negative (p = 5.8 × 10−11) and positive (p = 7.5 × 10−4) symptoms. In particular, social functional and skill levels were highly associated with notably subclinical negative symptoms levels.ConclusionsThis study shows strong correlations between levels of social impairments and subclinical negative and positive symptoms. However, longitudinal studies are required to show if social impairments represent early disease manifestations. If parental or self-reporting suggests severe social impairment, it should advocate for clinical awareness not only to social deficits per se but also of potential subclinical psychosis symptoms.

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Section: Discussionmentioning

confidence: 99%

Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

Vangkilde

Jepsen

Schmock

et al. 2016

J Neurodevelop Disord

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“…Hence, it is possible that the types of social concerns endorsed on the SRS (e.g., eye contact, odd behaviors, preference for being alone, ritualistic behaviors) may not relate as closely as we originally hypothesized to the TASIT's measurement of nuanced social cognition skills such as lie and sarcasm detection. have previously been proposed, with one pilot study that found targeted training in the identification of nonverbal social cues and perspective taking is associated with significant gains in social cognitive abilities in adolescents with 22q11DS (70). Adapting existing treatment models from idiopathic ASD and psychosis to better suit the cognitive needs of individuals with 22q11DS could improve social cognition, and thereby overall quality of life.…”

Section: Discussionmentioning

confidence: 99%

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Jalal

Nair

Lin

et al. 2020

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KEYWORDS 2 22q11.2 deletion, social cognition, neurocognition, psychosis, autism spectrum disorder 3 Abstract Background 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities.Finally, we examined the relationship between social cognitive abilities and real-world social behavior. MethodsWe examined social cognition and intellectual functioning in 306 participants (mean age = 16.63+/-4.59; % female = 44.8%): sixty-eight with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 117 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS).Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2 nd edition (WASI-II) to assess intellectual functioning. ResultsThe 22q11DS group exhibited significantly lower social cognitive abilities compared to all other groups, even after controlling for intellectual functioning. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. ConclusionsOur findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. the most common recurrent contiguous gene deletion syndrome, estimated to occur in about 1 in 4000 live births (2). It typically results from a de novo deletion, although 10% of cases are familial (3,4). 22q11DS is associated with a range of developmental anomalies (5). The most frequently associated medical comorbidities include congenital heart defects, facial dysmorphology such as palatal defects, immunodeficiency, velopharyngeal insufficiency, and hypocalcemia (2, 6).Individuals with 22q11DS often present with developmental delays, as well as broad cognitive impairment (6). In most individuals with 22q11DS, Full Scale IQ falls within the borderline to low average range (M = 72.41, SD = ± 13.72; 7). A range of associated cognitive deficits have also been noted in individuals with 22q11...

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“…Evidence from previous studies in idiopathic psychosis (93) and ASD (94) suggests that psychosocial and social skills training show positive treatment effects for both groups even 3-4 months post-treatment on average, suggesting good generalizability of social skills treatment gains, and improved overall functioning and sense of well-being. Intervention models directed at improving psychosocial function in individuals with 22q11DS have previously been proposed, with one pilot study that found targeted training in the identi cation of nonverbal social cues and perspective taking is associated with signi cant gains in social cognitive abilities in adolescents with 22q11DS (95). Adapting existing treatment models from idiopathic ASD and psychosis to better suit the cognitive needs of individuals with 22q11DS could improve social cognition, and thereby overall quality of life.…”

Section: Discussionmentioning

confidence: 99%

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Jalal

Nair

Lin

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. Methods: We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74+/-5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2 nd edition (WASI-II) to assess intellectual functioning. Results: The 22q11DS group exhibited significantly lower social cognitive abilities compared to all other groups, even after controlling for intellectual functioning. Significant positive correlations were found between social cognition, as measured by the TASIT, and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. Conclusions: Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment.

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Social cognitive training in adolescents with chromosome 22q11.2 deletion syndrome: feasibility and preliminary effects of the intervention

Cited by 41 publications

References 44 publications

Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

Social Cognition in 22q11.2 Deletion Syndrome and Idiopathic Developmental Neuropsychiatric Disorders

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