General Article SummarySubstantial biological model curation was essential for identifying differences in peak 23 time variance of the clock-proteins 'PERIOD' and 'TIMELESS', which probably stem 24 from differences in phosphorylation-network complexity. 25 We repeatedly encountered systemic limitations of contemporary data analysis 26 strategies in our work on circadian clocks. Thus, we used it as an opportunity for 27 composing a panoramic view of the broader challenges in biological model curation, 28 which are likely to increase as biologists aim to integrate all existing expertise in order to 29 address diverse grand challenges. We developed and tested a trans-disciplinary 30 research workflow, which enables biologists and compiler-architects to define biology-31 friendly compilers for efficiently constructing and maintaining Versioned Biological 32 Information Resources (VBIRs). We report insights gleaned from our practical clock 33 research that are essential for defining a VBIRs infrastructure, which improves the 34 efficiency of biological model curation to the point where it can be democratized. . CC-BY 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/099192 doi: bioRxiv preprint first posted online Jan. 9, 2017;. CC-BY 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/099192 doi: bioRxiv preprint first posted online Jan. 9, 2017;. CC-BY 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/099192 doi: bioRxiv preprint first posted online Jan. 9, 2017;. CC-BY 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/099192 doi: bioRxiv preprint first posted online Jan. 9, 2017;. CC-BY 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/099192 doi: bioRxiv preprint first posted online Jan. 9, 2017;. CC-BY 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/099192 doi: bioRxiv preprint first posted online Jan. 9, 2017;. CC-BY 4.0 International license It ...