Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: Effects of naloxone on nociception and behaviour

Rodgers, R.J.; Hendrie, Colin

doi:10.1016/0031-9384(83)90177-4

Cited by 126 publications

(44 citation statements)

References 33 publications

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“…The basic hypothesis was that attacked, and therefore defensive, intruders would display a post-encounter analgesia that should be blocked by an opiate receptor antagonist such as naloxone. The hypothesis was fully confirmed, not only in our lab [27,28] but also elsewhere [29][30][31].…”

Section: Antipredator Defence and Defensive Analgesiasupporting

confidence: 62%

“…The former dates back to the earlymid 1980s when we used video-technology to investigate in depth the effects of naloxone (e.g. [27,28]) and of benzodiazepine receptor ligands [60] on behaviours displayed during residentintruder encounters in rats and mice. The latter on the other hand is of very much more recent origin, dating from around the year 2000, and entails the use behavioural satiety sequence (BSS) methodology to fully characterise drug effects on rat behaviour during feeding tests (for review: [61]).…”

Section: The Presentmentioning

confidence: 99%

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No man is an island. A personal tribute to Bob Blanchard and ethoexperimental approaches to the study of behaviour

Rodgers

2015

Physiology & Behavior

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I first met Bob Blanchard at an international conference in Paris some 40 years ago. We collaborated intensively during the late 1980's/early 1990s on the ethopharmacology of antipredator defence in wild and laboratory rats, and remained good friends until his untimely passing in November 2013.Bob will undoubtedly be remembered as one of the most influential behavioural neuroscientists of the 20 th Century and, with Caroline, the most eloquent advocate of ethoexperimental approaches to the study of behaviour. In this brief trip down memory lane, I describe when and where Bob and I first met and how, over a lengthy period, he directly and indirectly helped shape my own research career.His profound influence in this regard is illustrated by reference not only to our collaborative research on antipredator behaviour but also my other work on the ethopharmacology of agonistic behaviour, social conflict analgesia, anxiety, and appetite. The element common to all of this work has been ethoexperimental analysis and, for teaching me the true value of this approach, I shall always remain indebted to the big man. Literally and figuratively, Bob was most certainly larger than life.

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Section: Antipredator Defence and Defensive Analgesiasupporting

confidence: 62%

Section: The Presentmentioning

confidence: 99%

No man is an island. A personal tribute to Bob Blanchard and ethoexperimental approaches to the study of behaviour

Rodgers

2015

Physiology & Behavior

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“…When threatened and attacked, subordinate rats rely on defensive and protective behaviors such as upright, supine and crouch postures and are relatively inactive (Rodgers and Hendrie 1983;Miczek et al 1991). Similar to open-field experiments in which increased freezing or immobility and decreased exploration are interpreted to reflect heightened "emotionality," subordinate animals quickly refrain from maladaptive activities such as increased locomotor activity and exploration in the presence of an attacking conspecific .…”

mentioning

confidence: 98%

Diazepam and gepirone selectively attenuate either 20–32 or 32–64 kHz ultrasonic vocalizations during aggressive encounters

Vivian

Miczek

1993

Psychopharmacology

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Ultrasonic vocalizations (USV) in rats may communicate "affective" states, as they occur only in highly significant behavioral contexts such as during sex, aggression, exposure to painful or startling events. This proposal was evaluated in an experiment with adult male Long-Evans rats during agonistic encounters; specifically, the effects of diazepam, flumazenil and gepirone were studied on different types of USV emitted by intruder rats exposed to resident attacks and to "threat of attacks" (i.e., intruder protected within the home cage of the resident by a wire mesh cage). USV were readily emitted during agonistic encounters and consisted primarily of two distributions of pure tone whistles: 0.3- to 3-s, 20- to 32-kHz ("low") signals and 0.02- to 0.3-s, 32- to 64-kHz ("high") signals. A considerable repertoire of frequency modulated signals was observed and proved to be sensitive to the anxiolytic treatments. Diazepam (1-6 mg/kg) dose-dependently decreased high frequency USV during the threat of attack and decreased the mean pitch of the most predominant vocalizations but did not affect low frequency USV or the audible squeals (AS) in response to bites. Gepirone (0.3-6 mg/kg) dose-dependently decreased low frequency USV and did not affect high frequency USV or AS. Responses to thermal pain stimuli remained unaltered by all drugs, while walking duration was decreased and crouch postures were increased after diazepam but not after gepirone administration. Gepirone in the present dose range had minimal effects on submissive, exploratory and locomotor behaviors. The pattern of results is consistent with the proposal that low frequency USV reflect a heightened affective state which is ameliorated with 5HT1A but not benzodiazepine anxiolytics, and suggests that the suppression of high frequency USV in reaction to attacks or threats coincides with the sedative or muscle relaxant properties of these compounds.

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“…As suggested earlier (Miczek et al 1982), Teskey et al (1984) found a higher level of analgesia in mice that displayed the characteristic defeat posture upon exposure to 35 bites than in attacked animals not displaying this particular behavior. Rodgers and Hendrie (1983), on the other hand, reported a positive correlation between the degree of analgesia in attacked mice and the duration of frozen crouch behavior. The present study investigated the relationship between social conflict analgesia and specific behavior shown during (experiment 1), as well as after the aggressive encounter (experiment 2).…”

mentioning

confidence: 92%

Relationship between behavioral and nociceptive changes in attacked mice: effects of opiate antagonists

Frischknecht

Siegfried

1989

Psychopharmacology

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The relationship between analgesia and behavior during and after an aggressive encounter was investigated in saline- and opiate antagonist-treated DBA mice. A low number of bites induced an analgesia that was reversed by beta-chlornaltrexamine but not by naloxone, and that correlated positively with increased displays of defensive upright and immobility upon contact with the opponent. Extended attacks induced a naloxone-sensitive analgesia that was linked to a delayed occurrence of "panic" escape behavior. In the post-conflict phase, the degree of immobility and analgesia correlated positively in attacked mice. Naltrexone prevented this analgesia and lowered immobility. Endogenous opioids released during social conflict may induce analgesia and immobility in DBA mice.

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Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: Effects of naloxone on nociception and behaviour

Cited by 126 publications

References 33 publications

No man is an island. A personal tribute to Bob Blanchard and ethoexperimental approaches to the study of behaviour

No man is an island. A personal tribute to Bob Blanchard and ethoexperimental approaches to the study of behaviour

Diazepam and gepirone selectively attenuate either 20–32 or 32–64 kHz ultrasonic vocalizations during aggressive encounters

Relationship between behavioral and nociceptive changes in attacked mice: effects of opiate antagonists

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