Social defeat stress enhances the rewarding effects of cocaine through α1A adrenoceptors in the medial prefrontal cortex of mice

Saito, Atsushi; Murata, Haruka; Niitani, Kazuhei; Nagasaki, Junpei; Otoda, Atsuki; Chujo, Yusuke; Yanagida, Junko; Nishitani, Naoya; Deyama, Satoshi; Kaneda, Katsuyuki

doi:10.1016/j.neuropharm.2023.109757

Cited by 2 publications

References 80 publications

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Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior

Nishitani,

Sasaki,

Kaneda

2024

Neuropsychopharm Rep

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Abstract3,4‐methylenedioxymethamphetamine (MDMA), a commonly abused recreational drug, induces prosocial effects such as increased sociability and empathy. The nucleus accumbens (NAc) has been suggested to play a crucial role in these MDMA‐mediated prosocial effects. However, the relationship between social behavior and NAc neural activity, and the effects of MDMA on this relationship, remain unknown. In this study, we measured NAc neural activity using fiber photometry and classified the behaviors of mice at times of transient increases in NAc neural activity during the social approach test (SAT). We found that NAc neural activity transiently increased at the onset of turning toward and sniffing novel mice during the SAT, although the frequency of turning was relatively low. We then examined the effects of MDMA on behavior and NAc neural activity and found that MDMA decreased the duration of sniffing per bout but did not alter NAc neural activity at the onset of turning toward or sniffing novel mice. These results suggest that MDMA does not affect the transient increase in NAc neural activity at the onset of social behaviors.

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Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior

Nishitani,

Sasaki,

Kaneda

2024

Neuropsychopharm Rep

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Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors

López,

Noble,

Özçete

et al. 2024

Preprint

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GPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. While experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor specificity in the brain frequently remains uncertain. Pursuing experiments in brain slices and in vivo, we find that norepinephrine and dopamine cross-activate the respective sensors. Non-specific activation occurred when innervation of the cross-reacting transmitter was high, and silencing of specific innervation was indispensable for interpreting sensor fluorescence.

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Social defeat stress enhances the rewarding effects of cocaine through α1A adrenoceptors in the medial prefrontal cortex of mice

Cited by 2 publications

References 80 publications

Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior

Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior

Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors

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